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Alternative TitleEffect of dexamethasone on retinal leukocyte accumulation, vascular permeability, and the expression of intercelluar adhension molecule -1 in experimental diabetic retinopathy
王康1; 王艳玲1; 高立新1; 李新民1; 李明铭1; 郭建友2
Other AbstractObjective To investigate the effect of intravitreal injection with dexamethasone on leukocyte accumulation, vascular permeability, and the expression of intercellular adhension molecule (ICAM-1) in rats with diabetes. Methods Seventy-two BN rats were divided into 4 groups: control group, diabetes group, diabetes + physiologic saline group, and diabetes+ dexamethasone group, with 18 rats in each group. Streptozotocin was injected into the rats to set up the diabetic model. Accumulated leukocytes were counted in vivo by acridine orange leukocyte fluorography, and retinal vascular permeability was measured by Evans blue assay. The expression of mRNA and protein level of ICAM-1 were evaluated by real-time quantitative polymerase chain reaction analysis and enzymedinked immunosorbent assay. Results In the diabetes+ dexamethasone group, accumulated leukocytes were reduced, retinal vascular permeability decreased, and the expression of ICAM-1 decreased. The expression of ICAM-1 mRNA and protein levels in control group, diabetes group, diabetes + physiologic saline group, and diabetes+ dexamethasone group were 0. 43±0. 07,0. 76±0.21,0.74±0.18,and 0. 55±0. 13; (37. 90±4. 56), (76.74±6.68), (74.32±7.11), and (39.61±4.47) pg/mg respectively. Conclusions Dexamethasone can reduce accumulated leukocytes and retinal vascular permeability, which may be caused by inhibiting the expression of ICAM-1.
Keyword糖尿病视网膜病变/病因学 糖尿病视网膜病变/病理生理学 血视网膜屏障/病理生理学 细胞黏附分子 地塞米松/治疗应用
Source Publication中华眼底病杂志
Indexed ByCSCD
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Cited Times:1[CSCD]   [CSCD Record]
Document Type期刊论文
Recommended Citation
GB/T 7714
王康,王艳玲,高立新,等. 地塞米松对糖尿病大鼠视网膜血管内白细胞聚集、血管通透性及细胞问黏附因子-1表达的影响[J]. 中华眼底病杂志,2007,23.0(004):273-276.
APA 王康,王艳玲,高立新,李新民,李明铭,&郭建友.(2007).地塞米松对糖尿病大鼠视网膜血管内白细胞聚集、血管通透性及细胞问黏附因子-1表达的影响.中华眼底病杂志,23.0(004),273-276.
MLA 王康,et al."地塞米松对糖尿病大鼠视网膜血管内白细胞聚集、血管通透性及细胞问黏附因子-1表达的影响".中华眼底病杂志 23.0.004(2007):273-276.
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