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神经性贪食患者额叶-纹状体神经环路静息态fMRI功能连接研究
Alternative TitleFunctional connectivity of the fronto-striatal circuitry in patients with bulimia nervosa based on resting-state fMRI
王钰萍1; 张宾1; 黄佳滨1; 亢清1; 岳玲1; 范青1; 陈楚侨2; 陈珏1; 肖泽萍1
First Author王钰萍
Correspondent Emailxiaozeping88@163.com
Contribution Rank3
Abstract

目的通过fMRI技术,探讨神经性贪食(bulimia nervosa,BN)患者静息态下额叶-纹状体环路的功能连接特点及其与抑制功能的相关性.方法对27例未用药的成年女性神经性贪食患者及27名性别、年龄、受教育年限与患者组匹配的健康对照被试进行信号停止任务(stop signal task,SST)测试;并行静息态fMRI扫描,分析比较两组纹状体功能亚区与额叶脑区间的功能连接差异.结果与对照组相比,BN组右侧腹头侧壳核(ventral rostral putamen,VRP)与右侧辅助运动区(supplementary motor areas,SMA)及运动前区(Premotor area,PM)间的功能连接减弱(MNI坐标:x=3,y=-15,z=51,K=27;MNI坐标:x=27,y=0,z=57,K=44);双侧背尾侧壳核(dorsal caudal putamen,DCP)(MNI坐标:x=21,y=-6,z=48,K=43)与右侧PM(MNI坐标:x=21,y=-12,z=57,K=24)间的功能连接减弱(P<0.05,Alphasim校正,voxel P<0.005,体素簇≥20个体素).BN组右侧VRP与右侧SMA的功能连接强度与停止信号反应时间(stop signal reaction time,SSRT)呈负相关(r=-0.595,P=0.004);右侧DCP与右侧PM间功能连接强度与冲动性调节评分(进食障碍调查量表-II)呈正相关(r=0.483,P=0.023).结论未用药成年女性神经性贪食患者存在静息态下额叶运动皮层与纹状体间的功能连接异常,该功能连接异常与BN患者的抑制功能受损有关.

Other Abstract

Objective To explore the functional connectivity (FC) of the fronto-striatal circuitry in patients with bulimia nervosa (BN) based on the resting-state fMRI and its correlation with the inhibitory function.Methods 27 medication-naive female patients with BN and 27 age-and education-matched female healthy control subjects were included in the study.All the subjects performed a stop signal task (SST) and underwent the resting-state fMRI scan,separately.The FC between striatal subregions and the frontal cortex was analyzed.Results Compared with healthy controls,FC between the right ventral rostral putamen (VRP) and the right supplementary motor areas (SMA) decreased (MNI coordinate:x =3,y =-15,z =51,K =27) in patients with BN.And the FC was also decreased between the right VRP and premotor area(PM) (MNI coordinate:x =27,y =0,z =57,K =44).FC between bilateral dorsal caudal putamen (DCP) (MNI coordinate:x=21,y=-6,z=48,K=43) and the right PM(MNI coordinate:x=21,y=-12,z=57,K=24) was decreased in patients with BN (P<0.05,Alphasim corrected,voxel P<0.005,clusters ≥ 20 voxels).FC between the right VRP and right SMA was negatively correlated with the stop signal reaction time (SSRT) in patients with BN (r=-0.595,P=0.004).The FC between right DCP and right PM was positively correlated with the impulsivity regulation subscale scores of the Eating Disorder Inventory-Ⅱ in patients with BN(r=0.483,P=0.023).Conclusion There is disrupted FC between the striatum and motor cortex in medication-naive female patients with BN based on resting-state fMRI,which may be related to impaired inhibitory control in patients with BN.

Keyword神经性贪食 静息态功能磁共振 额叶-纹状体环路 辅助运动区 运动前区
2018
Language中文
DOI10.3760/cma.j.issn.1674-6554.2018.04.006
Source Publication中华行为医学与脑科学杂志
ISSN1674-6554
Volume27Issue:4Pages:316-321
Subtype实证研究
URL查看原文
Indexed ByCSCD ; 中文核心期刊要目总览 ; 中国科技核心期刊
CSCD IDCSCD:6230960
Status非OA
Methodology脑成像
Statistical Method独立样本t检验;独立样本Mann-Whitney U检验;Person相关分析
Tests and Measures进食障碍调研量表;信号停止任务
Population人类
Instrument3.0T西门子Verio超导MR扫描系统
Gender
Age Group青年(18-29)
Statistical ToolsDPARSFA;SPSS 19.0
Dependent variables暴食分量表得分;冲动性调节分量表得分;GO信号与STOP信号之间的间隔时间;信号停止任务正确率;功能连接模式
Disorders神经性贪食症
Treatment信号停止任务
Number of Participants实验组27人;对照组27人
Country or Region中国
Province上海
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/34054
Collection健康与遗传心理学研究室
Corresponding Author肖泽萍
Affiliation1.上海交通大学
2.中国科学院心理研究所心理健康重点实验室
Recommended Citation
GB/T 7714
王钰萍,张宾,黄佳滨,等. 神经性贪食患者额叶-纹状体神经环路静息态fMRI功能连接研究[J]. 中华行为医学与脑科学杂志,2018,27(4):316-321.
APA 王钰萍.,张宾.,黄佳滨.,亢清.,岳玲.,...&肖泽萍.(2018).神经性贪食患者额叶-纹状体神经环路静息态fMRI功能连接研究.中华行为医学与脑科学杂志,27(4),316-321.
MLA 王钰萍,et al."神经性贪食患者额叶-纹状体神经环路静息态fMRI功能连接研究".中华行为医学与脑科学杂志 27.4(2018):316-321.
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