Institutional Repository of Key Laboratory of Mental Health, CAS
Abnormal auditory-evoked gamma band oscillations in first-episode schizophrenia during both eye open and eye close states | |
Junjie Wang1; Yingying Tang1; Adrian Curtin2,3; Raymond C.K. Chan4,5; Adrian Curtin4,5; Raymond C.K. Chan1; Tianhong Zhang1; Zhenying Qian1; Qian Guo1; Yu Li1; Xu Liu6,7; Xiaochen Tang1; Jijun Wang1,7,8,9 | |
第一作者 | Junjie Wang |
通讯作者邮箱 | yytang0522@gmail.com (y. tang) ; jijunwang27@163.com (j. wang) |
摘要 | Abnormal auditory steady state response (ASSR) is a typical finding among schizophrenia patients, which is thought to directly reflect deficient gamma band oscillations in the brain. However, whether these ASSR alterations are state dependent, e.g. during eye-open or eye-closed conditions, has not yet been carefully elucidated in schizophrenia. Our study aimed to explore whether the abnormality of ASSR in patients with firstepisode schizophrenia (FEP) is altered under eye-open (EO) and eye-closed (EC) states. ASSR was elicited using 40 Hz click trains under EO and EC states. Twenty-eight healthy control subjects (HC) and thirty-three FEP individuals, 17 of whom were medication-naïve, were recruited. The event-related spectrum perturbation (ERSP) and intertrial coherence (ITC) in response to 40 Hz click sounds were quantified. Compared to HC group, FEP group showed a lower ITC and ERSP during EO state, as well as a decreased ITC during EC state. Our results suggest that abnormalities in gamma band oscillations among first-episode schizophrenia patients are present under both eye open and eye close states. Although differences in gamma band oscillations between EO and EC states within the FEP group were not observed, exploratory results suggest that state-sensitivity may be contingent on medication use. |
关键词 | Eye open Eye close Auditory steady state response First-episode schizophrenia |
2018 | |
DOI | 10.1016/j.pnpbp.2018.04.016 |
发表期刊 | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY |
页码 | 279-286 |
期刊论文类型 | 实证研究 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/34111 |
专题 | 中国科学院心理健康重点实验室 |
作者单位 | 1.Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China 2.School of Biomedical Engineering & Health Sciences, Drexel University, Philadelphia, PA 19104, USA 3.Med-X Institute, Shanghai Jiaotong University University, Shanghai 200300, China 4.Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China 5.Department of Psychology, University of Chinese Academy of Sciences, Beijing, China 6.Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China 7.University of Chinese Academy of Sciences, Shanghai 200031, China 8.CAS Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of Science, China 9.Brain Science and Technology Research Center, Shanghai Jiaotong University, Shanghai 200030, China 10.Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiaotong University, Shanghai 200030, China |
推荐引用方式 GB/T 7714 | Junjie Wang,Yingying Tang,Adrian Curtin,et al. Abnormal auditory-evoked gamma band oscillations in first-episode schizophrenia during both eye open and eye close states[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2018:279-286. |
APA | Junjie Wang.,Yingying Tang.,Adrian Curtin.,Raymond C.K. Chan.,Adrian Curtin.,...&Jijun Wang.(2018).Abnormal auditory-evoked gamma band oscillations in first-episode schizophrenia during both eye open and eye close states.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,279-286. |
MLA | Junjie Wang,et al."Abnormal auditory-evoked gamma band oscillations in first-episode schizophrenia during both eye open and eye close states".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2018):279-286. |
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