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荆防挥发油对炎症相关因子表达和调节的影响
Alternative TitleEffects of volatie oil of Fineleaf schizonepeta herb and Divaricate saposhnikovia root on proinflammatory cytokine expression and regulation
葛卫红; 郭建友; 沈映君; 陈民利; 石森林; 韩玉环; 林洁
Abstract

目的:研究荆防挥发油对炎症相关因子表达和调节的影响。方法:用OA和LPS2次打击,建立2次打击急性肺损伤(ALI)模型。荆防挥发油(45.19μL.kg-1)对大鼠ALI模型支气管上皮细胞间黏附分子CD54,肺组织核因子-κB(NF-κB)p65、支气管上皮细胞中NF-κB p65 mRNA的组织化学观察及统计。结果:荆防挥发油能明显抑制CD54的表达、NF-κB p65的活化及阻止NF-κB p65 mRNA的转录增加。结论:荆防挥发油抑制CD54的表达,减少p65蛋白的合成可能是其抗炎的分子机制之一。

Keyword荆防挥发油 细胞间黏附分子CD54 核因子-κBp65
Subject Area系统生物学/生物信息学
2007
Language中文
Source Publication中国中药杂志
ISSN1001-5302
Volume32Issue:17Pages:1777-1779
Indexed ByCSCD ; 中文核心期刊要目总览
CSCD IDCSCD:2968803
Note

Objective:To study the effects of volatie oil of F.schizonepeta herb and D.saposhnikovia root(OSS) on proinflammatory cytokine expression and regulation in rats.Method:OA and LPS were injected intravenously to rats to develop ALI.The rats were treated with OSS(45.19 μL·kg-1).The pathological sections of lung tissue were prepared and observed in acute lung injury rats.The expression of nuclear factor-kappa B p65(NF-κB p65),intercellar adhesion molecule CD54,and NF-κB p65 mRNA were determined in lung cells.Re...

Citation statistics
Cited Times:4[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/3488
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding Author葛卫红
Recommended Citation
GB/T 7714
葛卫红,郭建友,沈映君,等. 荆防挥发油对炎症相关因子表达和调节的影响[J]. 中国中药杂志,2007,32(17):1777-1779.
APA 葛卫红.,郭建友.,沈映君.,陈民利.,石森林.,...&林洁.(2007).荆防挥发油对炎症相关因子表达和调节的影响.中国中药杂志,32(17),1777-1779.
MLA 葛卫红,et al."荆防挥发油对炎症相关因子表达和调节的影响".中国中药杂志 32.17(2007):1777-1779.
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