PSYCH OpenIR  > 中国科学院心理研究所回溯数据库(1956-2010)
脑心通胶囊对体外模拟脑缺血再灌注损伤大鼠脑微血管内皮细胞的保护作用
Alternative TitleProtective Effect of Naoxintong Capsules on Cultivated Rat Cerebral Microvascular Endothelial Cells Subjected to Simulated Cerebral Ischemia and Reperfusion in Vitro
刘振权; 徐秋萍; 张文生; 郭建友; 杜树山
2007
Source Publication中国药学杂志
ISSN1001-2494
Volume42Issue:10Pages:733-736
Abstract目的观察脑心通胶囊对体外模拟脑缺血再灌注损伤大鼠脑微血管内皮细胞的保护作用。方法建立体外培养大鼠脑微血管内皮细胞模拟脑缺血再灌注损伤模型,模拟脑缺血3h,再灌注1,3,6,12,24,36,48,72h后损伤内皮细胞的活性、死亡率变化以及脑心通胶囊的影响,测定体外培养大鼠脑微血管内皮细胞模拟脑缺血3h,再灌注24h时脑心通胶囊含药血清对细胞裂解液SOD活性、MDA及NO含量的影响。结果体外培养的大鼠脑微血管内皮细胞在模拟缺血再灌注损伤后,细胞内线粒体活力下降,死亡率升高,脑心通胶囊0.24,0.48g.kg-1能不同程度改善细胞损伤(P<0.05,P<0.01),明显提高裂解液中SOD活性(P<0.05,P<0.01),降低裂解液中MDA和NO含量(P<0.05,P<0.01),对大鼠脑微血管内皮细胞模拟脑缺血再灌注损伤有明显的保护作用。结论脑心通胶囊对体外培养大鼠脑微血管内皮细胞模拟脑缺血损伤有保护作用,其机制可能与抗脂质过氧化作用有关。
Keyword脑心通胶囊 脑缺血再灌注损伤 脑微血管内皮细胞 超氧化物歧化酶 丙二醛 一氧化氮
Subject Area生理心理学/生物心理学
Indexed By中文核心期刊要目总览 ASPT来源刊 中国期刊方阵 CJFD收录刊
Language中文
Funding Project北京市教委新医药学科群项目(227105803)
NoteOBJECTIVE To observe the protective effects of Naoxintong capsule(NXTJN)on the cultivated rat cerebral microvascular endothelial cells(rCMEC)subjected to simulated cerebral ischemia and reperfusion in vitro.METHODS rCMEC activity,motatity rate and the effects of NXTJN were observed after simulated cerebral ischemia for 3 h and reperfusion for 1,3,6,12,24,36,48 and 72 h,respectively.The change of SOD activity,MDA content and NO content of cell lysate and the effects of NXTJN were observed after simulated cer...
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/3520
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding Author刘振权
Recommended Citation
GB/T 7714
刘振权,徐秋萍,张文生,等. 脑心通胶囊对体外模拟脑缺血再灌注损伤大鼠脑微血管内皮细胞的保护作用[J]. 中国药学杂志,2007,42(10):733-736.
APA 刘振权,徐秋萍,张文生,郭建友,&杜树山.(2007).脑心通胶囊对体外模拟脑缺血再灌注损伤大鼠脑微血管内皮细胞的保护作用.中国药学杂志,42(10),733-736.
MLA 刘振权,et al."脑心通胶囊对体外模拟脑缺血再灌注损伤大鼠脑微血管内皮细胞的保护作用".中国药学杂志 42.10(2007):733-736.
Files in This Item:
File Name/Size DocType Version Access License
脑心通胶囊对体外模拟脑缺血再灌注损伤大鼠(215KB) 限制开放--View Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[刘振权]'s Articles
[徐秋萍]'s Articles
[张文生]'s Articles
Baidu academic
Similar articles in Baidu academic
[刘振权]'s Articles
[徐秋萍]'s Articles
[张文生]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[刘振权]'s Articles
[徐秋萍]'s Articles
[张文生]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 脑心通胶囊对体外模拟脑缺血再灌注损伤大鼠脑微血管内皮细胞的保护作用.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.