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下丘脑食欲素在药物成瘾中的作用
Alternative TitleRole of Hypothalamic Orexin in Drug Addiction
韩锦; 李勇辉; 白云静; 隋南
2007
Source Publication生理科学进展
ISSN0559-7765
Volume38Issue:4Pages:327-330
Abstract下丘脑是调控自然奖赏的重要脑区,它能特异性地表达一种神经肽——食欲素(orexin),这种神经肽在药物奖赏中的作用受到广泛关注。在成瘾研究中,发现不同脑区中的食欲素神经元对奖赏和动机行为的调节作用是不相同的:围穹窿区(PFA)和背内侧下丘脑区(DMH)的食欲素神经元主要参与激活应激系统,而外侧下丘脑(LH)的食欲素神经元主要通过激活与奖赏学习相关的大脑环路参与奖赏行为的调控。提示食欲素系统可在延长戒断防止复吸发生中成为新的研究目标,食欲素受体可以作为治疗药物成瘾的一种新的治疗靶标。
Keyword食欲素 药物成瘾 下丘脑
Subject Area医学心理学
Indexed By中文核心期刊要目总览 ASPT来源刊 CJFD收录刊
Language中文
Funding Project国家重点基础研究发展计划(973计划,2003CB515404);; 国家自然科学基金重点项目(30230130);; 中科院“西部之光”人才培养计划项目;; 国家自然科学基金面上项目(30600184);; 中国科学院知识创新工程重要方向项目基金(KSCX1-YW-R-68)资助课题
NoteHypothalamus is considered as an important brain region regulating natural rewards. Orexin, a neuropeptide specifically expressed in hypothalamus, arrests investigators much attention for its function in drug rewards. Orexin neurons in different brain regions exert different roles in regulating reward and motivation in the addiction research: orexin neurons in perifornical area (PFA) and dorsomedial hypothalamus (DMH) are mainly concerned with activating stress system, while orexin neurons in lateral hypot...
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/3622
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding Author隋南
Recommended Citation
GB/T 7714
韩锦,李勇辉,白云静,等. 下丘脑食欲素在药物成瘾中的作用[J]. 生理科学进展,2007,38(4):327-330.
APA 韩锦,李勇辉,白云静,&隋南.(2007).下丘脑食欲素在药物成瘾中的作用.生理科学进展,38(4),327-330.
MLA 韩锦,et al."下丘脑食欲素在药物成瘾中的作用".生理科学进展 38.4(2007):327-330.
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