Abnormal Effective Connectivity of the Anterior Forebrain Regions in Disorders of Consciousness

	Abnormal Effective Connectivity of the Anterior Forebrain Regions in Disorders of Consciousness
其他题名	Abnormal Effective Connectivity of the Anterior Forebrain Regions in Disorders of Consciousness
	Chen Ping 1; Xie Qiuyou 2; Wu Xiaoyan 1; Huang Huiyuan 1; Lv Wei 2; Chen Lixiang 1; Guo Yequn 2; Zhang Shufei 1; Hu Huiqing 1; Wang You 2; Nie Yangang 3; Yu Ronghao 2; Huang Ruiwang 1
摘要	A number of studies have indicated that disorders of consciousness result from multifocal injuries as well as from the impaired functional and anatomical connectivity between various anterior forebrain regions. However, the specific causal mechanism linking these regions remains unclear. In this study, we used spectral dynamic causal modeling to assess how the effective connections (ECs) between various regions differ between individuals. Next, we used connectome-based predictive modeling to evaluate the performance of the ECs in predicting the clinical scores of DOC patients. We found increased ECs from the striatum to the globus pallidus as well as from the globus pallidus to the posterior cingulate cortex, and decreased ECs from the globus pallidus to the thalamus and from the medial prefrontal cortex to the striatum in DOC patients as compared to healthy controls. Prediction of the patients’ outcome was effective using the negative ECs as features. In summary, the present study highlights a key role of the thalamo-basal ganglia-cortical loop in DOCs and supports the anterior forebrain mesocircuit hypothesis. Furthermore, EC could be potentially used to assess the consciousness level.
其他摘要	A number of studies have indicated that disorders of consciousness result from multifocal injuries as well as from the impaired functional and anatomical connectivity between various anterior forebrain regions. However, the specific causal mechanism linking these regions remains unclear. In this study, we used spectral dynamic causal modeling to assess how the effective connections (ECs) between various regions differ between individuals. Next, we used connectome-based predictive modeling to evaluate the performance of the ECs in predicting the clinical scores of DOC patients. We found increased ECs from the striatum to the globus pallidus as well as from the globus pallidus to the posterior cingulate cortex, and decreased ECs from the globus pallidus to the thalamus and from the medial prefrontal cortex to the striatum in DOC patients as compared to healthy controls. Prediction of the patients’ outcome was effective using the negative ECs as features. In summary, the present study highlights a key role of the thalamo-basal ganglia-cortical loop in DOCs and supports the anterior forebrain mesocircuit hypothesis. Furthermore, EC could be potentially used to assess the consciousness level.
关键词	DEFAULT MODE NETWORK MEDIAL PREFRONTAL CORTEX PROPOFOL-INDUCED LOSS SEVERELY INJURED BRAIN BASAL GANGLIA FUNCTIONAL CONNECTIVITY INDIRECT PATHWAYS IMPAIRED CONSCIOUSNESS PARKINSONS-DISEASE VEGETATIVE STATE Mesocircuit Basal ganglia Posterior cingulate cortex Spectral dynamic causal modeling Connectome-based predictive modeling
	2018
语种	英语
发表期刊	Neuroscience Bulletin
ISSN	1673-7067
卷号	34 期号:4 页码:647-658
收录类别	CSCD
资助项目	[National Natural Science Foundation of China] ; [Natural Science Foundation of Guangdong Province, China] ; [Planned Science and Technology Project of Guangzhou Municipality, China] ; [Innovation Project of The Graduate School of South China Normal University]
CSCD记录号	CSCD:6299978
引用统计	被引频次：2[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/37310
专题	中国科学院心理健康重点实验室
作者单位	1.中国科学院心理研究所 2.中国科学院广州地球化学研究所 3.广州大学
第一作者单位	中国科学院心理研究所
推荐引用方式 GB/T 7714	Chen Ping,Xie Qiuyou,Wu Xiaoyan,et al. Abnormal Effective Connectivity of the Anterior Forebrain Regions in Disorders of Consciousness[J]. Neuroscience Bulletin,2018,34(4):647-658.
APA	Chen Ping.,Xie Qiuyou.,Wu Xiaoyan.,Huang Huiyuan.,Lv Wei.,...&Huang Ruiwang.(2018).Abnormal Effective Connectivity of the Anterior Forebrain Regions in Disorders of Consciousness.Neuroscience Bulletin,34(4),647-658.
MLA	Chen Ping,et al."Abnormal Effective Connectivity of the Anterior Forebrain Regions in Disorders of Consciousness".Neuroscience Bulletin 34.4(2018):647-658.