Concordance among indices of intrinsic brain function: Insights from inter-individual variation and temporal dynamics

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	Concordance among indices of intrinsic brain function: Insights from inter-individual variation and temporal dynamics
其他题名	Concordance among indices of intrinsic brain function: Insights from inter-individual variation and temporal dynamics
	Yan ChaoGan 1; Yang Zhen 4; Colcombe Stanley J 4; Zuo XiNian 1; Milham Michael P 4
摘要	Various resting-state fMRI (R-fMRI) measures have been developed to characterize intrinsic brain activity. While each of these measures has gained a growing presence in the literature, questions remain regarding the common and unique aspects these indices capture. The present work provided a comprehensive examination of inter-individual variation and intra-individual temporal variation for commonly used measures, including fractional amplitude of low frequency fluctuations, regional homogeneity, voxel-mirrored homotopic connectivity, network centrality and global signal correlation. Regardless of whether examining intra-individual or inter-individual variation, we found that these definitionally distinct R-fMRI indices tend to exhibit a relatively high degree of covariation, which doesn't exist in phase randomized surrogate data. As a measure of intrinsic brain function, concordance for R-fMRI indices was negatively correlated with age across individuals (i.e., concordance among functional indices decreased with age). To understand the functional significance of concordance, we noted that higher concordance was generally associated with higher strengths of R-fMRI indices, regardless of whether looking through the lens of inter-individual (i.e., high vs. low concordance participants) or intra-individual (i.e., high vs. low concordance states identified via temporal dynamic analyses) differences. We also noted a linear increase in functional concordance together with the R-fMRI indices through the scan, which may suggest a decrease in arousal. The current study demonstrated an enriched picture regarding the relationship among the R-fMRI indices, as well as provided new insights in examining dynamic states within and between individuals. (C) 2017 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved.
其他摘要	Various resting-state fMRI (R-fMRI) measures have been developed to characterize intrinsic brain activity. While each of these measures has gained a growing presence in the literature, questions remain regarding the common and unique aspects these indices capture. The present work provided a comprehensive examination of inter-individual variation and intra-individual temporal variation for commonly used measures, including fractional amplitude of low frequency fluctuations, regional homogeneity, voxel-mirrored homotopic connectivity, network centrality and global signal correlation. Regardless of whether examining intra-individual or inter-individual variation, we found that these definitionally distinct R-fMRI indices tend to exhibit a relatively high degree of covariation, which doesn't exist in phase randomized surrogate data. As a measure of intrinsic brain function, concordance for R-fMRI indices was negatively correlated with age across individuals (i.e., concordance among functional indices decreased with age). To understand the functional significance of concordance, we noted that higher concordance was generally associated with higher strengths of R-fMRI indices, regardless of whether looking through the lens of inter-individual (i.e., high vs. low concordance participants) or intra-individual (i.e., high vs. low concordance states identified via temporal dynamic analyses) differences. We also noted a linear increase in functional concordance together with the R-fMRI indices through the scan, which may suggest a decrease in arousal. The current study demonstrated an enriched picture regarding the relationship among the R-fMRI indices, as well as provided new insights in examining dynamic states within and between individuals. (C) 2017 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved.
关键词	RESTING-STATE FMRI CONNECTIVITY MRI LIFE-SPAN DEVELOPMENTAL TRAJECTORIES REGIONAL HOMOGENEITY VASCULAR REACTIVITY ALZHEIMERS-DISEASE GLUCOSE-METABOLISM SIGNAL AMPLITUDE HEAD MOTION Resting-state fMRI Intrinsic brain activity Concordance Temporal dynamics Inter-individual variation
	2017-01-01
语种	英语
发表期刊	SCIENCE BULLETIN
ISSN	2095-9273
卷号	62 期号:23 页码:1572-1584
收录类别	CSCD
资助项目	[National Key R&D Program of China] ; [National Basic Research Program] ; [Natural Science Foundation of China] ; [Hundred Talents Program of the Chinese Academy of Sciences] ; [Beijing Municipal Science & Technology Commission] ; [National Institutes of Health] ; [Child Mind Institute]
CSCD记录号	CSCD:6150700
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/37538
作者单位	1.中国科学院心理研究所 2.中国科学院大学 3.中国科学院 4.Nathan S Kline Institute Psychiat Res, Orangeburg, NY 10962 USA 5.NYU, Langone Med Ctr, Sch Med, Department Child & Adolescent Psychiat, New York, NY 10016 USA 6.University Penn, Perelman Sch Med, Dept Psychiat, Ctr Neuromodulat Depress & Stress, Philadelphia, PA 19104 USA 7.Child Mind Institute, New York, NY 10022 USA
推荐引用方式 GB/T 7714	Yan ChaoGan,Yang Zhen,Colcombe Stanley J,et al. Concordance among indices of intrinsic brain function: Insights from inter-individual variation and temporal dynamics[J]. SCIENCE BULLETIN,2017,62(23):1572-1584.
APA	Yan ChaoGan,Yang Zhen,Colcombe Stanley J,Zuo XiNian,&Milham Michael P.(2017).Concordance among indices of intrinsic brain function: Insights from inter-individual variation and temporal dynamics.SCIENCE BULLETIN,62(23),1572-1584.
MLA	Yan ChaoGan,et al."Concordance among indices of intrinsic brain function: Insights from inter-individual variation and temporal dynamics".SCIENCE BULLETIN 62.23(2017):1572-1584.