PSYCH OpenIR  > 健康与遗传心理学研究室
Alternative TitleAdvances in Causes and Treatment of Autism
段云峰1; 吴晓丽1,2; 金锋1
First Author段云峰
Contribution Rank1


Other Abstract

Autism is a developmental disease, which may have a lifelong course, and the process is difficult to reverse. The cause of autism remains unclear and effective intervention and treatment have not been discovered. With increasing prevalence, autism causes huge economic burdens to the patients’ families and social burdens to the society. Autism is a biological disease that is influenced by both genetic and environmental factors. Early brain dysplasia may be the direct cause for autism, and neurotoxic substances, nutrients, metabolites and neuroactive substances are the most suspicious causes. While chromosomal abnormalities and genetic variation are found in some cases of autism, more cases showed abnormalities in gastrointestinal symptoms, a higher proportion of which may be associated with the human gut microbiota. The microorganism, the intestines and the brain form the gut-brain axis, which plays an important role in autism. Accordingly, many interventions have been developed including both biological and non-biological therapies. The biological therapies involve antibiotics, medicine and diet. Among these, a therapy targeting to intestinal microbes, such as interventions via probiotics and fecal transplantation, is booming. Although some of these treatments seemed relatively effective, most of them showed limitation in alleviating core symptoms of autism. Besides, there is not enough complete evaluation for safety and effectiveness. Therefore, future research needs to be performed in systematic and case-control studies for exploring the etiology of autism.

Keyword自闭症 病因 肠道微生物 饮食 菌-肠-脑轴
Source Publication中国科学. 生命科学
Indexed ByCSCD
Project Intro.

中国博士后科学基金(批准号: 2013M541072)和日本NS BIO JAPAN 株式会社和广东新日生物科技有限公司资助项目

Citation statistics
Cited Times:10[CSCD]   [CSCD Record]
Document Type期刊论文
Affiliation1.中国科学院心理研究所, 心理健康重点实验室, 北京
2.中国科学院大学, 北京
First Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
段云峰,吴晓丽,金锋. 自闭症的病因和治疗方法研究进展[J]. 中国科学. 生命科学,2015,45(9):820-844.
APA 段云峰,吴晓丽,&金锋.(2015).自闭症的病因和治疗方法研究进展.中国科学. 生命科学,45(9),820-844.
MLA 段云峰,et al."自闭症的病因和治疗方法研究进展".中国科学. 生命科学 45.9(2015):820-844.
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自闭症的病因和治疗方法研究进展.pdf(1529KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
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