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Co-occurrence of schizo-obsessive traits and its correlation with altered executive control network functional connectivity
Shan, Hai-Di1; Wang, Yong-Ming2,3,4; Hu, Hui-Xin1,2; Jiang, Shu-Yao1; Chu, Min-Yi1; Wang, Yi2,3; Lui, Simon S. Y.5,6; Cheung, Eric F. C.5; Wang, Zhen7,8,9; Chan, Raymond C. K.1,2,3,4
Corresponding AuthorChan, Raymond C. K.(rckchan2003@yahoo.com.hk)
AbstractThe prevalence of obsessive-compulsive symptoms (OCS) in schizophrenia patients is as around 30%. Evidence suggested that mild OCS could reduce symptoms of schizophrenia, supporting the presence of compensatory functions. However, severe OCS could aggravate various impairments in schizophrenia patients, supporting the "double jeopardy hypothesis". Patients with schizo-obsessive comorbidity, schizophrenia patients and obsessive-compulsive disorder patients have been found to have similarities in executive dysfunctions and altered resting-state functional connectivity within the executive control network (ECN). Executive functions could be associated with the ECN. However, little is known as to whether such overlap exists in the subclinical populations of individuals with schizo-obsessive traits (SOT), schizotypal individuals and individuals with high levels of obsessive-compulsive symptoms (OCS). In this study, we recruited 30 schizotypal individuals, 25 individuals with OCS, 29 individuals with SOT and 29 controls for a resting-state ECN-related functional connectivity (rsFC) and a go/shift/no-go task. We found that individuals with SOT exhibited increased rsFC within the ECN compared with controls, while schizotypal individuals exhibited the opposite. Individuals with OCS exhibited decreased rsFC within the ECN and between the ECN and the default mode network (DMN), relative to controls. No significant correlational results between altered rsFC related to the ECN with executive function performance were found after corrections for multiple comparisons in three subclinical groups. Our findings showed that individuals with SOT had increased rsFC within the ECN, while schizotypal individuals and individuals with OCS showed the opposite. Our findings provide evidence for possible neural substrates of subclinical comorbidity of OCS and schizotypy.
KeywordSchizotypal traits Obsessive-compulsive symptoms Schizo-obsessive traits Executive function Executive control network
2021-01-03
Language英语
DOI10.1007/s00406-020-01222-y
Source PublicationEUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
ISSN0940-1334
Pages12
Indexed BySCI
Funding ProjectNational Key Research and Development Programme[2016YFC0906402] ; Science Foundation of Shanghai Mental Health Centre[SMHCRSD01] ; CAS Key Laboratory of Mental Health, Institute of Psychology, the Chinese Academy of Sciences
PublisherSPRINGER HEIDELBERG
WOS KeywordMIDDLE TEMPORAL GYRUS ; COMPULSIVE SYMPTOMS ; 1ST-EPISODE SCHIZOPHRENIA ; BRAIN ; METAANALYSIS ; STATE ; ATTENTION ; DISORDER ; PARIETAL ; CORTEX
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectClinical Neurology ; Psychiatry
WOS IDWOS:000604153500001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/38143
Collection中国科学院心理健康重点实验室
Corresponding AuthorChan, Raymond C. K.
Affiliation1.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Translat Neuropsychol & Appl Cognit Neurosci Lab, 600 Wan Ping Nan Rd, Shanghai 200030, Peoples R China
2.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, 16 Lincui Rd, Beijing 100101, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Sino Danish Coll, Beijing, Peoples R China
5.Castle Peak Hosp, Hong Kong, Peoples R China
6.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
7.Shanghai Jiao Tong Univ, Inst Psychol & Behav Sci, Shanghai, Peoples R China
8.Shanghai Key Lab Psychot Disorders, Shanghai, Peoples R China
9.Univ Hong Kong, Dept Psychiat, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Shan, Hai-Di,Wang, Yong-Ming,Hu, Hui-Xin,et al. Co-occurrence of schizo-obsessive traits and its correlation with altered executive control network functional connectivity[J]. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,2021:12.
APA Shan, Hai-Di.,Wang, Yong-Ming.,Hu, Hui-Xin.,Jiang, Shu-Yao.,Chu, Min-Yi.,...&Chan, Raymond C. K..(2021).Co-occurrence of schizo-obsessive traits and its correlation with altered executive control network functional connectivity.EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,12.
MLA Shan, Hai-Di,et al."Co-occurrence of schizo-obsessive traits and its correlation with altered executive control network functional connectivity".EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2021):12.
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