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Glucose disturbances, cognitive deficits and white matter abnormalities in first-episode drug-naive schizophrenia (vol 25, pg 3220, 2020)
Zhang, Xiangyang1,2,3; Yang, Mi4,5; Du, Xiangdong6; Liao, Wei5; Chen, Dachun7; Fan, Fengmei7; Xiu, Meihong7; Jia, Qiufang6; Ning, Yuping3; Huang, Xingbing3; Wu, Fengchun3; Soares, Jair C.8; Cao, Bo8; Wang, Li1; Chen, Huafu5
First AuthorZhang, Xiangyang
Correspondent Emailzhangxy@psych.ac.cn (xiang yang zhang ) ; chenhf@uestc.edu.cn (huafu chen )
Contribution Rank1
Abstract

Disturbance of glucose metabolism may be implicated in cognitive deficits of schizophrenia in its early phases. Many studies have reported the important role of widespread disruption of white matter (WM) connectivity in pathogenesis, cognitive deficit and psychopathology of schizophrenia. However, no study has investigated their inter-relationships in drug-naive first episode (DNFE) patients with schizophrenia. Glucose metabolism parameters including fasting glucose, insulin and homeostasis model of assessment-insulin resistance (HOMA-IR) index, cognitive performance on the MATRICS Consensus Cognitive Battery (MCCB) and the voxel-wised WM fractional anisotropy (FA) values were examined using DTI in 39 DNFE schizophrenia and 31 control subjects. The Positive and Negative Syndrome Scale was utilized for clinical symptoms. The patients showed significantly greater fasting plasma levels of glucose and insulin and HOMA-IR, and poorer cognitive scores, together with widespread reduced FA values in five brain areas, including left and right corpus callosum, superior longitudinal fasciculus, posterior thalamic radiation, and corona radiata (all p < 0.05). Association analysis showed that glucose level was positively associated with Digital Sequence Test and Continuous Performance Test, but negatively with FA values in posterior

thalamic radiation and left corpus callosum in patients (all p < 0.05). Furthermore, multiple regression analysis revealed that the interactions of glucose × FA in left corpus callosum, longitudinal fasciculus and corona radiata were independent contributors to the Brief Visuospatial Memory Test (BVMT) of MCCB, while the interaction of glucose × FA in left corpus callosum, or in longitudinal fasciculus was associated with MCCB mazes and Trail Making A Test, respectively. Therefore, abnormal glucose metabolism, cognitive impairment and widespread disruption of WM structure occur in an early course of schizophrenia onset. An interaction between glucose metabolism abnormality and the WM dysconnectivity may lead to cognitive impairment.

2020-12-01
Language英语
DOI10.1038/s41380-019-0552-8
Source PublicationMOLECULAR PSYCHIATRY
ISSN1359-4184
Volume25Issue:12Pages:3454-3454
Subtype实证研究
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China (National Science Foundation of China)[81371477]
PublisherSPRINGERNATURE
WOS Research AreaBiochemistry & Molecular Biology ; Neurosciences & Neurology ; Psychiatry
WOS SubjectBiochemistry & Molecular Biology ; Neurosciences ; Psychiatry
WOS IDWOS:000608499700040
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/38152
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhang, Xiangyang; Chen, Huafu
Affiliation1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Guangzhou Med Univ, Guangzhou Huiai Hosp, Affiliated Brain Hosp, Guangzhou, Peoples R China
4.Fourth Peoples Hosp Chengdu, Dept Stomatol, Chengdu, Peoples R China
5.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu, Peoples R China
6.Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, Suzhou, Peoples R China
7.Peking Univ, Beijing HuiLongGuan Hosp, Psychiat Res Ctr, Beijing, Peoples R China
8.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Zhang, Xiangyang,Yang, Mi,Du, Xiangdong,et al. Glucose disturbances, cognitive deficits and white matter abnormalities in first-episode drug-naive schizophrenia (vol 25, pg 3220, 2020)[J]. MOLECULAR PSYCHIATRY,2020,25(12):3454-3454.
APA Zhang, Xiangyang.,Yang, Mi.,Du, Xiangdong.,Liao, Wei.,Chen, Dachun.,...&Chen, Huafu.(2020).Glucose disturbances, cognitive deficits and white matter abnormalities in first-episode drug-naive schizophrenia (vol 25, pg 3220, 2020).MOLECULAR PSYCHIATRY,25(12),3454-3454.
MLA Zhang, Xiangyang,et al."Glucose disturbances, cognitive deficits and white matter abnormalities in first-episode drug-naive schizophrenia (vol 25, pg 3220, 2020)".MOLECULAR PSYCHIATRY 25.12(2020):3454-3454.
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