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Interrelationships Between BDNF, Superoxide Dismutase, and Cognitive Impairment in Drug-Naive First-Episode Patients With Schizophrenia
Xiu, Mei Hong1; Li, Zezhi2; Chen, Da Chun1; Chen, Song1; Curbo, Maile E.3; Wu, Hanjing Emily3; Tong, Yong Sheng1; Tan, Shu Ping1; Zhang, Xiang Yang4,5
第一作者Mei Hong Xiu
通讯作者邮箱zhangxy@psych.ac.cn (x. zhang)
心理所单位排序4
摘要

The pathogenesis and etiology of schizophrenia (SCZ) remains unclear. Accumulating studies showed that complex interrelationships between brain-derived neurotrophic factor (BDNF) and an imbalanced redox system has a crucial role in the psychopathology of SCZ. However, the influence of the interrelationships of BDNF and superoxide dismutase (SOD) on cognitive impairment and clinical symptomatology in drug-naive first-episode (DNFE) SCZ patients has not been studied thoroughly. Serum BDNF levels, plasma total SOD, manganese-SOD (Mn-SOD), copper/zinc-containing SOD (CuZn-SOD) activities, and malondialdehyde (MDA) levels were measured in 327 DNFE patients with SCZ and 391 healthy controls. Cognitive functions were measured using the Repeatable Battery for the Assessment of Neuropsychological status (RBANS) and clinical symptoms were evaluated by the Positive and Negative Syndrome Scale (PANSS). Compared with the controls, the DNFE patients had increased activities of total SOD and CuZn-SOD, and reduced levels of BDNF and MDA. BDNF levels were positively correlated with CuZn-SOD activity in patients. In addition, we found that elevated Mn-SOD and CuZn-SOD activities were related to PANSS depression factor. Moreover, an interactive effect of BDNF levels and Mn-SOD activity was associated with attentional index score in the patients. Therefore, our findings suggested that interrelationships between BDNF and antioxidant mechanisms might underlie the pathological mechanisms of cognitive impairments and symptomatology in the DNFE patients with SCZ.

关键词schizophrenia BDNF superoxide dismutase interactive effect clinical symptoms cognitive function
2020-11-01
语种英语
DOI10.1093/schbul/sbaa062
发表期刊SCHIZOPHRENIA BULLETIN
ISSN0586-7614
卷号46期号:6页码:1498-1510
期刊论文类型实证研究
收录类别SCI
资助项目National Natural Science Foundation of China[81371477] ; National Natural Science Foundation of China[81000509]
出版者OXFORD UNIV PRESS
WOS关键词NEUROTROPHIC FACTOR LEVELS ; NEGATIVE SYNDROME SCALE ; OXIDATIVE STRESS ; CEREBROSPINAL-FLUID ; ASSOCIATION ; DOPAMINE ; SYMPTOMS ; ACID ; SOD1 ; METAANALYSIS
WOS研究方向Psychiatry
WOS类目Psychiatry
WOS记录号WOS:000607041400020
引用统计
被引频次:42[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/38155
专题中国科学院心理健康重点实验室
通讯作者Zhang, Xiang Yang
作者单位1.Peking Univ, Beijing HuiLongGuan Hosp, HuiLongGuan Clin Med Sch, Beijing, Peoples R China
2.Shanghai Jiao Tong Univ, Ren Ji Hosp, Dept Neurol, Sch Med, Shanghai, Peoples R China
3.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX USA
4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
通讯作者单位中国科学院心理健康重点实验室
推荐引用方式
GB/T 7714
Xiu, Mei Hong,Li, Zezhi,Chen, Da Chun,et al. Interrelationships Between BDNF, Superoxide Dismutase, and Cognitive Impairment in Drug-Naive First-Episode Patients With Schizophrenia[J]. SCHIZOPHRENIA BULLETIN,2020,46(6):1498-1510.
APA Xiu, Mei Hong.,Li, Zezhi.,Chen, Da Chun.,Chen, Song.,Curbo, Maile E..,...&Zhang, Xiang Yang.(2020).Interrelationships Between BDNF, Superoxide Dismutase, and Cognitive Impairment in Drug-Naive First-Episode Patients With Schizophrenia.SCHIZOPHRENIA BULLETIN,46(6),1498-1510.
MLA Xiu, Mei Hong,et al."Interrelationships Between BDNF, Superoxide Dismutase, and Cognitive Impairment in Drug-Naive First-Episode Patients With Schizophrenia".SCHIZOPHRENIA BULLETIN 46.6(2020):1498-1510.
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