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Interrelationships Between BDNF, Superoxide Dismutase, and Cognitive Impairment in Drug-Naive First-Episode Patients With Schizophrenia | |
Xiu, Mei Hong1; Li, Zezhi2; Chen, Da Chun1; Chen, Song1; Curbo, Maile E.3; Wu, Hanjing Emily3; Tong, Yong Sheng1; Tan, Shu Ping1; Zhang, Xiang Yang4,5 | |
第一作者 | Mei Hong Xiu |
通讯作者邮箱 | zhangxy@psych.ac.cn (x. zhang) |
心理所单位排序 | 4 |
摘要 | The pathogenesis and etiology of schizophrenia (SCZ) remains unclear. Accumulating studies showed that complex interrelationships between brain-derived neurotrophic factor (BDNF) and an imbalanced redox system has a crucial role in the psychopathology of SCZ. However, the influence of the interrelationships of BDNF and superoxide dismutase (SOD) on cognitive impairment and clinical symptomatology in drug-naive first-episode (DNFE) SCZ patients has not been studied thoroughly. Serum BDNF levels, plasma total SOD, manganese-SOD (Mn-SOD), copper/zinc-containing SOD (CuZn-SOD) activities, and malondialdehyde (MDA) levels were measured in 327 DNFE patients with SCZ and 391 healthy controls. Cognitive functions were measured using the Repeatable Battery for the Assessment of Neuropsychological status (RBANS) and clinical symptoms were evaluated by the Positive and Negative Syndrome Scale (PANSS). Compared with the controls, the DNFE patients had increased activities of total SOD and CuZn-SOD, and reduced levels of BDNF and MDA. BDNF levels were positively correlated with CuZn-SOD activity in patients. In addition, we found that elevated Mn-SOD and CuZn-SOD activities were related to PANSS depression factor. Moreover, an interactive effect of BDNF levels and Mn-SOD activity was associated with attentional index score in the patients. Therefore, our findings suggested that interrelationships between BDNF and antioxidant mechanisms might underlie the pathological mechanisms of cognitive impairments and symptomatology in the DNFE patients with SCZ. |
关键词 | schizophrenia BDNF superoxide dismutase interactive effect clinical symptoms cognitive function |
2020-11-01 | |
语种 | 英语 |
DOI | 10.1093/schbul/sbaa062 |
发表期刊 | SCHIZOPHRENIA BULLETIN |
ISSN | 0586-7614 |
卷号 | 46期号:6页码:1498-1510 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China[81371477] ; National Natural Science Foundation of China[81000509] |
出版者 | OXFORD UNIV PRESS |
WOS关键词 | NEUROTROPHIC FACTOR LEVELS ; NEGATIVE SYNDROME SCALE ; OXIDATIVE STRESS ; CEREBROSPINAL-FLUID ; ASSOCIATION ; DOPAMINE ; SYMPTOMS ; ACID ; SOD1 ; METAANALYSIS |
WOS研究方向 | Psychiatry |
WOS类目 | Psychiatry |
WOS记录号 | WOS:000607041400020 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/38155 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Zhang, Xiang Yang |
作者单位 | 1.Peking Univ, Beijing HuiLongGuan Hosp, HuiLongGuan Clin Med Sch, Beijing, Peoples R China 2.Shanghai Jiao Tong Univ, Ren Ji Hosp, Dept Neurol, Sch Med, Shanghai, Peoples R China 3.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX USA 4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Xiu, Mei Hong,Li, Zezhi,Chen, Da Chun,et al. Interrelationships Between BDNF, Superoxide Dismutase, and Cognitive Impairment in Drug-Naive First-Episode Patients With Schizophrenia[J]. SCHIZOPHRENIA BULLETIN,2020,46(6):1498-1510. |
APA | Xiu, Mei Hong.,Li, Zezhi.,Chen, Da Chun.,Chen, Song.,Curbo, Maile E..,...&Zhang, Xiang Yang.(2020).Interrelationships Between BDNF, Superoxide Dismutase, and Cognitive Impairment in Drug-Naive First-Episode Patients With Schizophrenia.SCHIZOPHRENIA BULLETIN,46(6),1498-1510. |
MLA | Xiu, Mei Hong,et al."Interrelationships Between BDNF, Superoxide Dismutase, and Cognitive Impairment in Drug-Naive First-Episode Patients With Schizophrenia".SCHIZOPHRENIA BULLETIN 46.6(2020):1498-1510. |
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