Aberrant effective connectivity is associated with positive symptoms in first-episode schizophrenia

doi:10.1016/j.nicl.2020.102444

	Aberrant effective connectivity is associated with positive symptoms in first-episode schizophrenia
	Dietz, Martin J.1; Zhou, Yuan2,3 ; Veddum, Lotte 4,5; Frith, Christopher D.6,7; Bliksted, Vibeke F.4,5,7
通讯作者	Dietz, Martin J.(martin@cfin.au.dk)
摘要	Schizophrenia is a neurodevelopmental psychiatric disorder thought to result from synaptic dysfunction that affects distributed brain connectivity, rather than any particular brain region. While symptomatology is traditionally divided into positive and negative symptoms, abnormal social cognition is now recognized a key component of schizophrenia. Nonetheless, we are still lacking a mechanistic understanding of effective brain connectivity in schizophrenia during social cognition and how it relates to clinical symptomatology. To address this question, we used fMRI and dynamic causal modelling (DCM) to test for abnormal brain connectivity in twenty-four patients with first-episode schizophrenia (FES) compared to twenty-five matched controls performing the Human Connectome Project (HCP) social cognition paradigm. Patients had not received regular therapeutic antipsychotics, but were not completely drug naive. Whilst patients were less accurate than controls in judging social stimuli from non-social stimuli, our results revealed an increase in feedforward connectivity from motion-sensitive V5 to posterior superior temporal sulcus (pSTS) in patients compared to matched controls. At the same time, patients with a higher degree of positive symptoms had more disinhibition within pSTS, a region computationally involved in social cognition. We interpret these findings the framework of active inference, where increased feedforward connectivity may encode aberrant prediction errors from V5 to pSTS and local disinhibition within pSTS may reflect aberrant encoding of the precision of cortical representations about social stimuli.
关键词	Schizophrenia Social cognition Brain-symptom mapping Dynamic causal modelling (DCM) Parametric empirical Bayes (PEB)
	2020
语种	英语
DOI	10.1016/j.nicl.2020.102444
发表期刊	NEUROIMAGE-CLINICAL
ISSN	2213-1582
卷号	28 页码:11
收录类别	SCI
资助项目	Interacting Minds Center, Aarhus University ; VELUX FONDEN[00013930]
出版者	ELSEVIER SCI LTD
WOS关键词	SOCIAL COGNITION ; MISMATCH NEGATIVITY ; SYNAPTIC PLASTICITY ; FREE-ENERGY ; BRAIN ; MIND ; METAANALYSIS ; ONSET ; TASK ; FMRI
WOS研究方向	Neurosciences & Neurology
WOS类目	Neuroimaging
WOS记录号	WOS:000600619100087
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/38172
专题	中国科学院行为科学重点实验室
通讯作者	Dietz, Martin J.
作者单位	1.Aarhus Univ, Ctr Funct Integrat Neurosci, Inst Clin Med, Norrebrogade 44,01A, DK-8000 Aarhus C, Denmark 2.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 4.Aarhus Univ Hosp, Psychosis Res Unit, Aarhus, Denmark 5.Aarhus Univ, Inst Clin Med, Aarhus, Denmark 6.UCL, Wellcome Ctr Human Neuroimaging, London, England 7.Aarhus Univ, Interacting Minds Ctr, Aarhus, Denmark
推荐引用方式 GB/T 7714	Dietz, Martin J.,Zhou, Yuan,Veddum, Lotte,et al. Aberrant effective connectivity is associated with positive symptoms in first-episode schizophrenia[J]. NEUROIMAGE-CLINICAL,2020,28:11.
APA	Dietz, Martin J.,Zhou, Yuan,Veddum, Lotte,Frith, Christopher D.,&Bliksted, Vibeke F..(2020).Aberrant effective connectivity is associated with positive symptoms in first-episode schizophrenia.NEUROIMAGE-CLINICAL,28,11.
MLA	Dietz, Martin J.,et al."Aberrant effective connectivity is associated with positive symptoms in first-episode schizophrenia".NEUROIMAGE-CLINICAL 28(2020):11.