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Post-traumatic stress symptoms of children and adolescents exposed to the 2008 Wenchuan Earthquake: A longitudinal study of 5-HTTLPR genotype main effects and gene-environment interactions
Li, Gen1,2; Wang, Li1,2; Cao, Chengqi1,3; Fang, Ruojiao1,2; Hall, Brian J.4,5; Elhai, Jon D.6,7; Liberzon, Israel8
First AuthorLi, Gen
Correspondent Emailwangli1@psych.ac.cn (wang, li)
Contribution Rank1
Abstract

Experiencing disasters causes severe mental disorders, among which post-traumatic stress disorder (PTSD) is the most common. We conducted a longitudinal study to examine the effect of 5-hydroxyl tryptamine transporter gene-linked polymorphic region (5-HTTLPR) genotype on child and adolescent PTSD symptom course after the 2008 Wenchuan Earthquake. We genotyped 963 participants who personally experienced the earthquake. PTSD symptoms were measured by University of California, Los Angeles PTSD reaction index at 2.5, 3.5, 4.5 and 5.5 years after the earthquake, respectively. Latent growth model was utilised to examine the main effect and gene-environment interaction effect of 5-HTTLPR on PTSD's symptom course. 5-HTTLPR genotype predicted initial PTSD symptom severity (beta = 0.108, p = .019) and rates of symptom recovery (beta = -0.120, p = .031) between 2.5 and 5.5 years. Compared with L ' allele carriers, those with S ' S ' genotype showed higher initial symptom severity but also faster recovery rate. 5-HTTLPR genotype only predicted symptom severity at 2.5 years after the earthquake, after controlling for sex, age, ethnicity and trauma severity (beta = 0.108, p = .019). This is the first evidence of the effect of 5-HTTLPR genotype on child and adolescent PTSD symptoms longitudinally, offering a novel perspective on the effect of 5-HTTLPR on PTSD symptom development following trauma exposure.

Keyword5‐ Hydroxyl tryptamine transporter gene‐ linked polymorphic region Post‐ traumatic stress disorder Symptom course Disaster Children and adolescents
2021-02-01
DOI10.1002/ijop.12614
Source PublicationINTERNATIONAL JOURNAL OF PSYCHOLOGY
ISSN0020-7594
Volume56Issue:1Pages:22-29
Subtype实证研究
Indexed BySCI
Funding ProjectBeijing Municipal Science and Technology Commission[Z171100000117014] ; External Cooperation Program of Chinese Academy of Sciences[153111KYSB20160036] ; Key Research Program of the Chinese Academy of Sciences[ZDRW-XH-2019-4] ; National Natural Science Foundation of China[31271099] ; National Natural Science Foundation of China[31471004] ; Key Project of Research Base of Humanities and Social Sciences of Ministry of Education[16JJD190006]
PublisherJOHN WILEY & SONS LTD
WOS Research AreaPsychology
WOS SubjectPsychology, Multidisciplinary
WOS IDWOS:000609915200003
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/38178
Collection中国科学院心理健康重点实验室
Corresponding AuthorWang, Li
Affiliation1.Chinese Acad Sci, Inst Psychol, Lab Traumat Stress Studies, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Shenzhen Univ, Shenzhen Key Lab Affect & Social Cognit Sci, Shenzhen, Peoples R China
4.Univ Macau, Dept Psychol, Global & Community Mental Hlth Res Grp, Fac Social Sci, Macau, Peoples R China
5.Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Behav & Soc, Baltimore, MD USA
6.Univ Toledo, Dept Psychol, Toledo, OH 43606 USA
7.Univ Toledo, Dept Psychiat, 2801 W Bancroft St, Toledo, OH 43606 USA
8.Texas A&M Coll Med, Dept Psychiat, College Stn, TX USA
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Li, Gen,Wang, Li,Cao, Chengqi,et al. Post-traumatic stress symptoms of children and adolescents exposed to the 2008 Wenchuan Earthquake: A longitudinal study of 5-HTTLPR genotype main effects and gene-environment interactions[J]. INTERNATIONAL JOURNAL OF PSYCHOLOGY,2021,56(1):22-29.
APA Li, Gen.,Wang, Li.,Cao, Chengqi.,Fang, Ruojiao.,Hall, Brian J..,...&Liberzon, Israel.(2021).Post-traumatic stress symptoms of children and adolescents exposed to the 2008 Wenchuan Earthquake: A longitudinal study of 5-HTTLPR genotype main effects and gene-environment interactions.INTERNATIONAL JOURNAL OF PSYCHOLOGY,56(1),22-29.
MLA Li, Gen,et al."Post-traumatic stress symptoms of children and adolescents exposed to the 2008 Wenchuan Earthquake: A longitudinal study of 5-HTTLPR genotype main effects and gene-environment interactions".INTERNATIONAL JOURNAL OF PSYCHOLOGY 56.1(2021):22-29.
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