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The role of lipoprotein profile in depression and cognitive performance: a network analysis | |
Jia, Qiu-fang1; Yang, Han-xue2; Zhuang, Nan-nan1; Yin, Xu-yuan1; Zhu, Zhen-hua1; Yuan, Ying1; Yin, Xiao-li; Wang, Yi2,3; Cheung, Eric F. C.4; Chan, Raymond C. K.2,5; Hui, Li1 | |
第一作者 | Jia, Qiu-fang |
通讯作者邮箱 | rckchan@psych.ac.cn (r.c.k. chan) ; huili004100@126.com (hui, li) |
心理所单位排序 | 2 |
摘要 | Lipid profile (total cholesterol and lipoprotein fractions) has been found to correlate with depression and cognitive impairment across the lifespan. However, the role of lipid levels in self-rated depressive state and cognitive impairment remains unclear. In this study, we examined the relationship between lipid profile (total cholesterol, triglycerides, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol) and cognition in adults with and without self-rated depression. Four hundred and thirty-eight healthy participants completed the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), the Self-Rating Depression Scale (SDS), and a serum lipoprotein test. Using multivariate ANOVA, partial correlation and network analysis, a network linking lipoprotein profile, depressive state and cognition was constructed. A significant difference in serum lipid profile between the high and low depressive groups was detected. Depressive state had a strong negative correlation with cognitive performance. Of the lipid profile, only high-density lipoprotein was positively correlated with depressive symptom severity, whereas the other three indices showed negative correlation with both depressive state and cognitive performance. Our results suggest that serum lipid profile may be directly linked to self-rated depression and cognitive performance. Further studies recruiting larger clinical samples are needed to elucidate the specific effect of lipoprotein on cognitive impairment in mood disorder. |
2020-12-26 | |
DOI | 10.1038/s41598-020-77782-9 |
发表期刊 | SCIENTIFIC REPORTS |
ISSN | 2045-2322 |
卷号 | 10期号:1页码:7 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China[81771439] ; Jiangsu Provincial Key Research and Development Program[BE2020661] ; Jiangsu Provincial Health Commission Science Research Program[H2019056] ; Jiangsu Provincial Health Commission Science Research Program[LGY2018010] ; Jiangsu Provincial High-level Health Talent Project[QNRC2016228] ; Jiangsu Provincial Six Talent Peaks Project[WSN-165] ; Suzhou Municipal Health Commission Program[LCZX201820] ; Suzhou Municipal Health Commission Program[Gwzx201801] ; Suzhou Municipal Sci-Tech Bureau Program[SZS201722] ; Suzhou Municipal Sci-Tech Bureau Program[SYS2019113] ; Suzhou Municipal Sci-Tech Bureau Program[SS2019009] ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2019K03] |
出版者 | NATURE RESEARCH |
WOS关键词 | HIGH-DENSITY-LIPOPROTEIN ; SERUM-LIPID CONCENTRATIONS ; MIDDLE-AGED MEN ; CHINESE NONAGENARIANS ; CHOLESTEROL ; SYMPTOMS ; ASSOCIATION ; BATTERY ; MEMORY ; COHORT |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000596329600060 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/38198 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Chan, Raymond C. K.; Hui, Li |
作者单位 | 1.Soochow Univ, Med Coll, Affiliated Guangji Hosp, Suzhou, Jiangsu, Peoples R China 2.CAS Key Lab Mental Hlth Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China 3.Wenzhou Med Univ, Wenzhou Kangning Hosp, Wenzhou, Zhejiang, Peoples R China 4.Castle Peak Hosp, Hong Kong, Peoples R China 5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Jia, Qiu-fang,Yang, Han-xue,Zhuang, Nan-nan,et al. The role of lipoprotein profile in depression and cognitive performance: a network analysis[J]. SCIENTIFIC REPORTS,2020,10(1):7. |
APA | Jia, Qiu-fang.,Yang, Han-xue.,Zhuang, Nan-nan.,Yin, Xu-yuan.,Zhu, Zhen-hua.,...&Hui, Li.(2020).The role of lipoprotein profile in depression and cognitive performance: a network analysis.SCIENTIFIC REPORTS,10(1),7. |
MLA | Jia, Qiu-fang,et al."The role of lipoprotein profile in depression and cognitive performance: a network analysis".SCIENTIFIC REPORTS 10.1(2020):7. |
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