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The role of lipoprotein profile in depression and cognitive performance: a network analysis
Jia, Qiu-fang1; Yang, Han-xue2; Zhuang, Nan-nan1; Yin, Xu-yuan1; Zhu, Zhen-hua1; Yuan, Ying1; Yin, Xiao-li; Wang, Yi2,3; Cheung, Eric F. C.4; Chan, Raymond C. K.2,5; Hui, Li1
Corresponding AuthorChan, Raymond C. K.(rckchan@psych.ac.cn) ; Hui, Li(huili004100@126.com)
AbstractLipid profile (total cholesterol and lipoprotein fractions) has been found to correlate with depression and cognitive impairment across the lifespan. However, the role of lipid levels in self-rated depressive state and cognitive impairment remains unclear. In this study, we examined the relationship between lipid profile (total cholesterol, triglycerides, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol) and cognition in adults with and without self-rated depression. Four hundred and thirty-eight healthy participants completed the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), the Self-Rating Depression Scale (SDS), and a serum lipoprotein test. Using multivariate ANOVA, partial correlation and network analysis, a network linking lipoprotein profile, depressive state and cognition was constructed. A significant difference in serum lipid profile between the high and low depressive groups was detected. Depressive state had a strong negative correlation with cognitive performance. Of the lipid profile, only high-density lipoprotein was positively correlated with depressive symptom severity, whereas the other three indices showed negative correlation with both depressive state and cognitive performance. Our results suggest that serum lipid profile may be directly linked to self-rated depression and cognitive performance. Further studies recruiting larger clinical samples are needed to elucidate the specific effect of lipoprotein on cognitive impairment in mood disorder.
2020-12-26
Language英语
DOI10.1038/s41598-020-77782-9
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume10Issue:1Pages:7
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[81771439] ; Jiangsu Provincial Key Research and Development Program[BE2020661] ; Jiangsu Provincial Health Commission Science Research Program[H2019056] ; Jiangsu Provincial Health Commission Science Research Program[LGY2018010] ; Jiangsu Provincial High-level Health Talent Project[QNRC2016228] ; Jiangsu Provincial Six Talent Peaks Project[WSN-165] ; Suzhou Municipal Health Commission Program[LCZX201820] ; Suzhou Municipal Health Commission Program[Gwzx201801] ; Suzhou Municipal Sci-Tech Bureau Program[SZS201722] ; Suzhou Municipal Sci-Tech Bureau Program[SYS2019113] ; Suzhou Municipal Sci-Tech Bureau Program[SS2019009] ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2019K03]
PublisherNATURE RESEARCH
WOS KeywordHIGH-DENSITY-LIPOPROTEIN ; SERUM-LIPID CONCENTRATIONS ; MIDDLE-AGED MEN ; CHINESE NONAGENARIANS ; CHOLESTEROL ; SYMPTOMS ; ASSOCIATION ; BATTERY ; MEMORY ; COHORT
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000596329600060
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/38198
Collection中国科学院心理健康重点实验室
Corresponding AuthorChan, Raymond C. K.; Hui, Li
Affiliation1.Soochow Univ, Med Coll, Affiliated Guangji Hosp, Suzhou, Jiangsu, Peoples R China
2.CAS Key Lab Mental Hlth Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
3.Wenzhou Med Univ, Wenzhou Kangning Hosp, Wenzhou, Zhejiang, Peoples R China
4.Castle Peak Hosp, Hong Kong, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Jia, Qiu-fang,Yang, Han-xue,Zhuang, Nan-nan,et al. The role of lipoprotein profile in depression and cognitive performance: a network analysis[J]. SCIENTIFIC REPORTS,2020,10(1):7.
APA Jia, Qiu-fang.,Yang, Han-xue.,Zhuang, Nan-nan.,Yin, Xu-yuan.,Zhu, Zhen-hua.,...&Hui, Li.(2020).The role of lipoprotein profile in depression and cognitive performance: a network analysis.SCIENTIFIC REPORTS,10(1),7.
MLA Jia, Qiu-fang,et al."The role of lipoprotein profile in depression and cognitive performance: a network analysis".SCIENTIFIC REPORTS 10.1(2020):7.
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