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Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis
Wang, Xin1; Xie, Hong2; Chen, Tian3; Cotton, Andrew S.1; Salminen, Lauren E.4; Logue, Mark W.5,6; Clarke-Rubright, Emily K.7,8; Wall, John2; Dennis, Emily L.4,9; O'Leary, Brian M.1; Abdallah, Chadi G.10,11; Andrew, Elpiniki12; Baugh, Lee A.13,14,15; Bomyea, Jessica16,17; Bruce, Steven E.18; Bryant, Richard19; Choi, Kyle20; Daniels, Judith K.21; Davenport, Nicholas D.22,23; Davidson, Richard J.24,25,26; DeBellis, Michael27; DeRoon-Cassini, Terri28; Disner, Seth G.22,23; Fani, Negar29; Fercho, Kelene A.13,14,15,30; Fitzgerald, Jacklynn31; Forster, Gina L.13,32; Frijling, Jessie L.33; Geuze, Elbert34,35; Gomaa, Hassaan36; Gordon, Evan M.37; Grupe, Dan25; Harpaz-Rotem, Ilan10,11; Haswell, Courtney C.7,8; Herzog, Julia I.38; Hofmann, David39; Hollifield, Michael40; Hosseini, Bobak41; Hudson, Anna R.42; Ipser, Jonathan43; Jahanshad, Neda4; Jovanovic, Tanja44; Kaufman, Milissa L.45,46; King, Anthony P.47; Koch, Saskia B. J.33,48; Koerte, Inga K.49,50; Korgaonkar, Mayuresh S.51; Krystal, John H.10,11; Larson, Christine52; Lebois, Lauren A. M.46,53; Levy, Ifat10,54; Li, Gen55,56; Magnotta, Vincent A.57,58,59; Manthey, Antje60,61,62,63; May, Geoffrey64,65,66,67; McLaughlin, Katie A.68; Mueller, Sven C.42,69; Nawijn, Laura33,70; Nelson, Steven M.64,65,66; Neria, Yuval71,72; Nitschke, Jack B.26; Olff, Miranda33,73; Olson, Elizabeth A.46,74; Peverill, Matthew75; Luan Phan, K.41,76,77; Rashid, Faisal M.4; Ressler, Kerry46,53; Rosso, Isabelle M.46,74; Sambrook, Kelly78; Schmahl, Christian38,79; Shenton, Martha E.46,49,80,81; Sierk, Anika60,61,62,63,82; Simons, Jeffrey S.15,83; Simons, Raluca M.14,83; Sponheim, Scott R.22,23; Stein, Murray B.17,84; Stein, Dan J.85,86; Stevens, Jennifer S.29; Straube, Thomas39; Suarez-Jimenez, Benjamin71,72; Tamburrino, Marijo1; Thomopoulos, Sophia I.4; van der Wee, Nic J. A.87,88; van der Werff, Steven J. A.87,88; van Erp, Theo G. M.89,90; van Rooij, Sanne J. H.29; van Zuiden, Mirjam33; Varkevisser, Tim34,35; Veltman, Dick J.70; Vermeiren, Robert R. J. M.91,92; Walter, Henrik60,61,62,63; Wang, Li56,93; Zhu, Ye55,56; Zhu, Xi71,72; Thompson, Paul M.4; Morey, Rajendra A.7,8; Liberzon, Israel67
Corresponding AuthorWang, Xin(xin.wang2@utoledo.edu)
AbstractStudies of posttraumatic stress disorder (PTSD) report volume abnormalities in multiple regions of the cerebral cortex. However, findings for many regions, particularly regions outside commonly studied emotion-related prefrontal, insular, and limbic regions, are inconsistent and tentative. Also, few studies address the possibility that PTSD abnormalities may be confounded by comorbid depression. A mega-analysis investigating all cortical regions in a large sample of PTSD and control subjects can potentially provide new insight into these issues. Given this perspective, our group aggregated regional volumes data of 68 cortical regions across both hemispheres from 1379 PTSD patients to 2192 controls without PTSD after data were processed by 32 international laboratories using ENIGMA standardized procedures. We examined whether regional cortical volumes were different in PTSD vs. controls, were associated with posttraumatic stress symptom (PTSS) severity, or were affected by comorbid depression. Volumes of left and right lateral orbitofrontal gyri (LOFG), left superior temporal gyrus, and right insular, lingual and superior parietal gyri were significantly smaller, on average, in PTSD patients than controls (standardized coefficients = -0.111 to -0.068, FDR corrected P values < 0.039) and were significantly negatively correlated with PTSS severity. After adjusting for depression symptoms, the PTSD findings in left and right LOFG remained significant. These findings indicate that cortical volumes in PTSD patients are smaller in prefrontal regulatory regions, as well as in broader emotion and sensory processing cortical regions.
2020-12-07
Language英语
DOI10.1038/s41380-020-00967-1
Source PublicationMOLECULAR PSYCHIATRY
ISSN1359-4184
Pages13
Indexed BySCI
Funding ProjectAnonymous Women's Health Fund ; Barlow Family Fund ; CDMRP[W81XWH-08-2-0038] ; Academic Medical Center Research Council[110614] ; BOF[01J05415] ; Center for Brain and Behavior Research Pilot Grant[CX001600 VA CDA] ; Dana Foundation ; DoD[W81XWH08-2-0159] ; DoD[W81XWH-10-1-0925] ; DoD[W81XWH-12-2-0012] ; DoD[F32MH109274] ; German Research Foundation[DA 1222/4-1] ; German Research Foundation[WA 1539/8-2] ; German Research Society (Deutsche Forschungsgemeinschaft, DFG)[SFB/TRR 58] ; German Research Society (Deutsche Forschungsgemeinschaft, DFG)[HD071982] ; German Research Society (Deutsche Forschungsgemeinschaft, DFG)[HD085850] ; German Research Society (Deutsche Forschungsgemeinschaft, DFG)[K01MH118428] ; German Research Society (Deutsche Forschungsgemeinschaft, DFG)[K23MH090366-01] ; German Research Society (Deutsche Forschungsgemeinschaft, DFG)[K24DA028773] ; German Research Society (Deutsche Forschungsgemeinschaft, DFG)[K24MH71434] ; German Research Society (Deutsche Forschungsgemeinschaft, DFG)[K99NS096116] ; Kasparian Fund[L30MH114379] ; Kasparian Fund[M01RR00039] ; Kasparian Fund[MH071537] ; Kasparian Fund[MH098212] ; Kasparian Fund[MH101380] ; Kasparian Fund[MJFF 14848] ; NARSAD- Young Investigator Grant ; National Institute of Child Health and Human Development[P30-HD003352] ; NCATS (CTSA)- Yale Center for Clinical Investigation ; Netherlands Organization for Health Research and Development[40-00812-98-10041] ; NHMRC Program Grant[1073041] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[P30HD003352] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[P41EB015922] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R01AA12479] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R01AG059874] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R01MH043454] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R01MH096987] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R01MH103291] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R01MH105355] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R01MH105535] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R01MH110483] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R01MH111671] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R01MH116147] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R01MH117601] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R01MH61744] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R01MH63407] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R21MH097196] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R21MH098198] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R21MH112956] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R56AG058854] ; South African Medical Research Council ; South Dakota Governor's Research Center Grant[T32MH018931] ; Trauma Scholars Fund[U54EB020403] ; UCI-LBVA Biumvirate Grant[UL1TR000153] ; UCI-LBVA Biumvirate Grant[UL1TR000454] ; University of Wisconsin Institute for Clinical and Translational Research ; VA CSRD[1IK2CX001680] ; VA Merit Review Program ; VA National Center for PTSD ; VA[RRD1IK2RX000709] ; VA[RRD1K1RX002325] ; VA[RRD1K2RX002922] ; VA[RRDI01RX000622] ; VISN6 MIRECC ; [1R21MH102634] ; [5U01AA021681-08]
PublisherSPRINGERNATURE
WOS KeywordSTRUCTURAL BRAIN ABNORMALITIES ; MAJOR DEPRESSIVE DISORDER ; VOXEL-BASED-MORPHOMETRY ; HIPPOCAMPAL VOLUME ; PREFRONTAL CORTEX ; MATTER REDUCTION ; METAANALYSIS ; CINGULATE ; INDIVIDUALS ; ASSOCIATION
WOS Research AreaBiochemistry & Molecular Biology ; Neurosciences & Neurology ; Psychiatry
WOS SubjectBiochemistry & Molecular Biology ; Neurosciences ; Psychiatry
WOS IDWOS:000598988400002
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/38204
Collection中国科学院心理健康重点实验室
Corresponding AuthorWang, Xin
Affiliation1.Univ Toledo, Dept Psychiat, 2801 W Bancroft St, Toledo, OH 43606 USA
2.Univ Toledo, Dept Neurosci, 2801 W Bancroft St, Toledo, OH 43606 USA
3.Univ Toledo, Dept Math & Stat, 2801 W Bancroft St, Toledo, OH 43606 USA
4.Univ Southern Calif, Keck Sch Med, Imaging Genet Ctr, Mark & Mary Stevens Neuroimaging & Informat Inst, Marina Del Rey, CA USA
5.VA Boston Healthcare Syst, Natl Ctr PTSD, Boston, MA USA
6.Boston Univ, Dept Psychiat, Sch Med, Boston, MA 02215 USA
7.Duke Univ, Brain Imaging & Anal Ctr, Durham, NC USA
8.Durham VA Hlth Care Syst, VISN 6 MIRECC, Durham, NC USA
9.Univ Utah, Dept Neurol, Salt Lake City, UT USA
10.VA Connecticut Healthcare Syst, Natl Ctr PTSD, Clin Neurosci Div, West Haven, CT USA
11.Yale Univ, Dept Psychiat, Sch Med, New Haven, CT USA
12.Univ Sydney, Westmead, NSW, Australia
13.Univ South Dakota, Sanford Sch Med, Div Basic BioMed Sci, Vermillion, SD USA
14.Univ South Dakota, Ctr Brain & Behav Res, Vermillion, SD USA
15.Sioux Falls VA Hlth Care Syst, Sioux Falls, SD USA
16.VA San Diego Healthcare Syst, Ctr Excellence Stress & Mental Hlth, San Diego, CA USA
17.Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA
18.Univ Missouri, Ctr Trauma Recovery, Dept Psychol Sci, St. Louis, MO USA
19.Univ New South Wales, Sch Psychol, Sydney, NSW, Australia
20.Univ Calif San Diego, Hlth Serv Res Ctr, La Jolla, CA 92093 USA
21.Univ Groningen, Dept Clin Psychol, Groningen, Netherlands
22.Minneapolis VA Hlth Care Syst, Minneapolis, MN USA
23.Univ Minnesota, Dept Psychiat & Behav Sci, Minneapolis, MN USA
24.Univ Wisconsin, Ctr Hlth Minds, Madison, WI USA
25.Univ Wisconsin, Dept Psychol, 1202 W Johnson St, Madison, WI 53706 USA
26.Univ Wisconsin, Dept Psychiat, Madison, WI 53706 USA
27.Duke Univ, Dept Psychiat & Behav Sci, Durham, NC USA
28.Med Coll Wisconsin, Dept Surg, Div Trauma & Acute Care Surg, Milwaukee, WI USA
29.Emory Univ, Dept Psychiat & Behav Sci, Sch Med, Atlanta, GA 30322 USA
30.US Fed Avit Adm, Civil Aerosp Med Inst, Oklahoma City, OK USA
31.Marquette Univ, Dept Psychol, Milwaukee, WI 53233 USA
32.Univ Otago, Brain Hlth Res Ctr, Dept Anat, Dunedin, New Zealand
33.Univ Amsterdam, Med Ctr, Dept Psychiat, Locat Acad Med Ctr,Amsterdam Neurosci, Amsterdam, Netherlands
34.Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Psychiat, Utrecht, Netherlands
35.Minist Def, Brain Res & Innovat Ctr, Utrecht, Netherlands
36.Penn State Coll Med, Dept Psychiat & Behav Hlth, Hershey, PA USA
37.Washington Univ, Dept Radiol, Sch Med, St. Louis, MO USA
38.Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Psychosomat Med & Psychotherapy, Heidelberg, Germany
39.Univ Munster, Inst Med Psychol & Syst Neurosci, Munster, Germany
40.Tibor Rubin VA Med Ctr, Program Traumat Stress, Long Beach, CA USA
41.Univ Illinois, Dept Psychiat, Chicago, IL USA
42.Univ Ghent, Dept Expt Clin & Hlth Psychol, Ghent, Belgium
43.Univ Cape Town, Dept Psychiat, Cape Town, South Africa
44.Wayne State Univ, Dept Psychiat & Behav Neurosci, Detroit, MI USA
45.McLean Hosp, Div Womens Mental Hlth, Belmont, MA USA
46.Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA
47.Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA
48.Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Ctr Cognit Neuroimaging, Nijmegen, Netherlands
49.Brigham & Womens Hosp, Psychiat Neuroimaging Lab, 75 Francis St, Boston, MA 02115 USA
50.Ludwig Maximilians Univ Munchen, Dept Child & Adolescent Psychiat Psychosomat & Ps, Munich, Germany
51.Univ Sydney, Westmead Inst Med Res, Brain Dynam Ctr, Westmead, NSW, Australia
52.Univ Wisconsin, Dept Psychol, Milwaukee, WI 53201 USA
53.McLean Hosp, Div Depress & Anxiety Disorders, 115 Mill St, Belmont, MA 02178 USA
54.Yale Univ, Sch Med, Dept Comparat Med, New Haven, CT USA
55.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
56.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
57.Univ Iowa, Dept Radiol, Iowa City, IA 52242 USA
58.Univ Iowa, Dept Psychiat, Iowa City, IA 52242 USA
59.Univ Iowa, Dept Biomed Engn, Iowa City, IA 52242 USA
60.Charite Univ Med Berlin, Berlin, Germany
61.Free Univ Berlin, Berlin, Germany
62.Humboldt Univ, Berlin, Germany
63.Berlin Inst Hlth, Berlin, Germany
64.Doris Miller VA Med Ctr, VISN 17 Ctr Excellence Res Returning War Vet, Waco, TX USA
65.Univ Texas Dallas, Ctr Vital Longev, Sch Behav & Brain Sci, Dallas, TX USA
66.Baylor Univ, Dept Psychol & Neurosci, Waco, TX 76798 USA
67.Texas A&M Univ, Dept Psychiat & Behav Sci, College Stn, TX USA
68.Harvard Univ, Dept Psychol, Boston, MA 02115 USA
69.Univ Deusto, Dept Personal, Psychol Assessment & Treatment, Bilbao, Spain
70.Univ Amsterdam, Locat Univ Med Ctr, Med Ctr, Dept Psychiat, Amsterdam, Netherlands
71.Columbia Univ, Dept Psychiat, Med Ctr, New York, NY USA
72.New York State Psychiat Inst & Hosp, New York, NY 10032 USA
73.ARQ Natl Psychotrauma Ctr, Diemen, Netherlands
74.McLean Hosp, Ctr Depress Anxiety & Stress Res, 115 Mill St, Belmont, MA 02178 USA
75.Univ Washington, Dept Psychol, Seattle, WA 98195 USA
76.Ohio State Univ, Wexner Med Ctr, Columbus, OH 43210 USA
77.Jesse Brown VA Med Ctr, Mental Hlth Serv Line, Chicago, IL USA
78.Univ Washington, Dept Radiol, Seattle, WA 98195 USA
79.Univ Western Ontario, Dept Psychiat, London, ON, Canada
80.VA Boston Healthcare Syst, Dept Psychiat, Brockton, MA USA
81.Harvard Med Sch, Dept Radiol, Boston, MA 02115 USA
82.UCL, Inst Cognit Neurosci, London, England
83.Univ South Dakota, Dept Psychol, Vermillion, SD USA
84.Univ Calif San Diego, Dept Family Med & Publ Hlth, La Jolla, CA 92093 USA
85.Univ Cape Town, SAMRC Unit Risk & Resilience Mental Disorders, Dept Psychiat, Cape Town, South Africa
86.Univ Cape Town, SAMRC Unit Risk & Resilience Mental Disorders, Neurosci Inst, Cape Town, South Africa
87.Leiden Univ, Dept Psychiat, Med Ctr, Leiden, Netherlands
88.Leiden Inst Brain & Cognit, Leiden, Netherlands
89.Univ Calif Irvine, Clin Translat Neurosci Lab, Dept Psychiat & Human Behav, Irvine, CA USA
90.Univ Calif Irvine, Ctr Neurobiol Learning & Memory, Irvine, CA USA
91.Leiden Univ, Child & Adolescent Psychiat, Med Ctr, Leiden, Netherlands
92.Youz Parnassia Grp, Leiden, Netherlands
93.Chinese Acad Sci, Inst Psychol, Lab Traumat Stress Studies, CAS Key Lab Mental Hlth, Beijing, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wang, Xin,Xie, Hong,Chen, Tian,et al. Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis[J]. MOLECULAR PSYCHIATRY,2020:13.
APA Wang, Xin.,Xie, Hong.,Chen, Tian.,Cotton, Andrew S..,Salminen, Lauren E..,...&Liberzon, Israel.(2020).Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis.MOLECULAR PSYCHIATRY,13.
MLA Wang, Xin,et al."Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis".MOLECULAR PSYCHIATRY (2020):13.
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