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Structural abnormalities of cingulate cortex in patients with first-episode drug-naive schizophrenia comorbid with depressive symptoms
Wei, Gao-Xia1,2,3; Ge, Likun1,3; Chen, Li-Zhen1,3; Cao, Bo4; Zhang, Xiangyang1
Corresponding AuthorZhang, Xiangyang(zhangxy@psych.ac.cn)
AbstractDepressive symptoms are common in patients with first-episode psychosis. However, the neural mechanisms underlying the comorbid depression in schizophrenia are still unknown. The main purpose of this study was to characterize the structural abnormalities of first-episodes drug-naive (FEDN) schizophrenia comorbid with depression by utilizing both volume-based and surface-based morphometric measurements. Forty-two patients with FEDN schizophrenia and 29 healthy controls were recruited. The 24-item Hamilton Depression Rating Scale (HAMD-24) was administrated to divide all patients into depressive patients (DP) and non-depressive patients (NDP). Compared with NDP, DP had a significantly larger volume and surface area in the left isthmus cingulate cortex and also had a greater volume in the left posterior cingulate cortex. Correlation analysis showed that HAMD total score was positively correlated with the surface area of the left isthmus cingulate and gray matter volume of the left isthmus cingulate cortex. In addition, gray matter volume of the left isthmus cingulate was also correlated with the PANSS general psychopathology or total score. The findings suggest that prominent structural abnormalities of gray matter are mainly concentrated on the cingulate cortex in FEDN schizophrenia patients comorbid with depression, which may contribute to depressive symptoms and psychopathological symptoms.
Keywordcomorbidity gray matter psychiatry subcortical structures
2020-12-09
Language英语
DOI10.1002/hbm.25315
Source PublicationHUMAN BRAIN MAPPING
ISSN1065-9471
Pages9
Indexed BySCI
Funding ProjectScientific Foundation of Institute of Psychology ; Chinese Academy of Sciences[Y9CX402008] ; Open Research Fund of the CAS Key Laboratory of Behavioral Science, Institute of Psychology ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2011ZK07] ; National Natural Science Foundation of China[31671163]
PublisherWILEY
WOS KeywordPOSTERIOR CINGULATE ; MATTER ABNORMALITIES ; METAANALYSIS ; EPISODE ; VOLUME ; RISK ; PEOPLE ; MEMORY ; SCALE ; OLDER
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000596701500001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/38207
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhang, Xiangyang
Affiliation1.Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Univ Alberta, Fac Med & Dent, Dept Psychiat, Edmonton, AB, Canada
First Author AffilicationKey Laboratory of Mental Health, CAS;  Key Laboratory of Behavioral Science, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Wei, Gao-Xia,Ge, Likun,Chen, Li-Zhen,et al. Structural abnormalities of cingulate cortex in patients with first-episode drug-naive schizophrenia comorbid with depressive symptoms[J]. HUMAN BRAIN MAPPING,2020:9.
APA Wei, Gao-Xia,Ge, Likun,Chen, Li-Zhen,Cao, Bo,&Zhang, Xiangyang.(2020).Structural abnormalities of cingulate cortex in patients with first-episode drug-naive schizophrenia comorbid with depressive symptoms.HUMAN BRAIN MAPPING,9.
MLA Wei, Gao-Xia,et al."Structural abnormalities of cingulate cortex in patients with first-episode drug-naive schizophrenia comorbid with depressive symptoms".HUMAN BRAIN MAPPING (2020):9.
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