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| Structural abnormalities of cingulate cortex in patients with first-episode drug-naive schizophrenia comorbid with depressive symptoms | |
Wei, Gao-Xia1,2,3 ; Ge, Likun1,3; Chen, Li-Zhen1,3; Cao, Bo4; Zhang, Xiangyang1
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| Corresponding Author | Zhang, Xiangyang(zhangxy@psych.ac.cn) |
| Abstract | Depressive symptoms are common in patients with first-episode psychosis. However, the neural mechanisms underlying the comorbid depression in schizophrenia are still unknown. The main purpose of this study was to characterize the structural abnormalities of first-episodes drug-naive (FEDN) schizophrenia comorbid with depression by utilizing both volume-based and surface-based morphometric measurements. Forty-two patients with FEDN schizophrenia and 29 healthy controls were recruited. The 24-item Hamilton Depression Rating Scale (HAMD-24) was administrated to divide all patients into depressive patients (DP) and non-depressive patients (NDP). Compared with NDP, DP had a significantly larger volume and surface area in the left isthmus cingulate cortex and also had a greater volume in the left posterior cingulate cortex. Correlation analysis showed that HAMD total score was positively correlated with the surface area of the left isthmus cingulate and gray matter volume of the left isthmus cingulate cortex. In addition, gray matter volume of the left isthmus cingulate was also correlated with the PANSS general psychopathology or total score. The findings suggest that prominent structural abnormalities of gray matter are mainly concentrated on the cingulate cortex in FEDN schizophrenia patients comorbid with depression, which may contribute to depressive symptoms and psychopathological symptoms. |
| Keyword | comorbidity gray matter psychiatry subcortical structures |
| 2020-12-09 | |
| Language | 英语 |
| DOI | 10.1002/hbm.25315 |
| Source Publication | HUMAN BRAIN MAPPING
 |
| ISSN | 1065-9471 |
| Pages | 9 |
| Indexed By | SCI |
| Funding Project | Scientific Foundation of Institute of Psychology ; Chinese Academy of Sciences[Y9CX402008] ; Open Research Fund of the CAS Key Laboratory of Behavioral Science, Institute of Psychology ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2011ZK07] ; National Natural Science Foundation of China[31671163] |
| Publisher | WILEY |
| WOS Keyword | POSTERIOR CINGULATE ; MATTER ABNORMALITIES ; METAANALYSIS ; EPISODE ; VOLUME ; RISK ; PEOPLE ; MEMORY ; SCALE ; OLDER |
| WOS Research Area | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS Subject | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS ID | WOS:000596701500001 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.psych.ac.cn/handle/311026/38207 |
| Collection | 中国科学院心理健康重点实验室 |
| Corresponding Author | Zhang, Xiangyang |
| Affiliation | 1.Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China 2.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Univ Alberta, Fac Med & Dent, Dept Psychiat, Edmonton, AB, Canada |
| First Author Affilication | Key Laboratory of Mental Health, CAS; Key Laboratory of Behavioral Science, CAS |
| Corresponding Author Affilication | Key Laboratory of Mental Health, CAS |
| Recommended Citation GB/T 7714 | Wei, Gao-Xia,Ge, Likun,Chen, Li-Zhen,et al. Structural abnormalities of cingulate cortex in patients with first-episode drug-naive schizophrenia comorbid with depressive symptoms[J]. HUMAN BRAIN MAPPING,2020:9. |
| APA | Wei, Gao-Xia,Ge, Likun,Chen, Li-Zhen,Cao, Bo,&Zhang, Xiangyang.(2020).Structural abnormalities of cingulate cortex in patients with first-episode drug-naive schizophrenia comorbid with depressive symptoms.HUMAN BRAIN MAPPING,9. |
| MLA | Wei, Gao-Xia,et al."Structural abnormalities of cingulate cortex in patients with first-episode drug-naive schizophrenia comorbid with depressive symptoms".HUMAN BRAIN MAPPING (2020):9. |
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