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A New Dichoptic Training Strategy Leads to Better Cooperation Between the Two Eyes in Amblyopia | |
Liu, Zitian1; Chen, Zidong1; Gao, Le1; Liu, Manli1; Huang, Yiru1; Feng, Lei1; Yuan, Junpeng1; Deng, Daming1; Huang, Chang-Bing2,3; Yu, Minbin1 | |
通讯作者邮箱 | yuminbin@mail.sysu.edu.cn (minbin yu ) ; huangcb@psych.ac.cn (chang-bing huang) |
心理所单位排序 | 2 |
摘要 | Recent clinical trials failed to endorse dichoptic training for amblyopia treatment. Here, we proposed an alternative training strategy that focused on reducing signal threshold contrast in the amblyopic eye under a constant and high noise contrast in the fellow eye (HNC), and compared it to a typical dichoptic strategy that aimed at increasing the tolerable noise contrast in the fellow eye (i.e., TNC strategy). We recruited 16 patients with amblyopia and divided them into two groups. Eight patients in Group 1 received the HNC training, while the other eight patients in Group 2 performed the TNC training first (Phase 1) and then crossed over to the HNC training (Phase 2). We measured contrast sensitivity functions (CSFs) separately in the amblyopic and fellow eyes when the untested eye viewed mean luminance (monocularly unmasked) or noise stimuli (dichoptically masked) before and after training at a particular frequency. The area under the log contrast sensitivity function (AULCSF) of masked and unmasked conditions, and dichoptic gain (the ratio of AULCSF of masked to unmasked condition) were calculated for each eye. We found that both dichoptic training paradigms substantially improved masked CSF, dichoptic gain, and visual acuity in the amblyopic eye. As opposed to the TNC paradigm, the HNC training produced stronger effects on masked CSFs, stereoacuity, dichoptic gain, and visual acuity in the amblyopic eye. Interestingly, the second-phase HNC training in Group 2 also induced further improvement in the masked contrast sensitivity and AULCSF in the amblyopic eye. We concluded that the HNC training strategy was more effective than the TNC training paradigm. Future design for dichoptic training should not only focus on increasing the tolerable noise contrast in the fellow eye but should also "nurture" the amblyopic eye under normal binocular viewing conditions and sustained interocular suppression. |
关键词 | amblyopia dichoptic training dichoptic masking contrast sensitivity functions interocular suppression |
2020-11-26 | |
语种 | 英语 |
DOI | 10.3389/fnins.2020.593119 |
发表期刊 | FRONTIERS IN NEUROSCIENCE |
卷号 | 14页码:14 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | Natural Science Foundation Team Project of Guangdong Province Grant[2015A030312016] ; Science and Technology Planning Projects of Guangdong Province[2014B030301040] ; Scientific Instrument Developing Project of the Chinese Academy of Sciences[ZDKYYQ20200005] ; Natural Science Foundation of China[NSFC 32071056] ; National Natural Science Foundation for Young Scientists[81600761] |
出版者 | FRONTIERS MEDIA SA |
WOS关键词 | IMPROVES CONTRAST SENSITIVITY ; BINOCULAR IPAD GAME ; ADULT AMBLYOPIA ; ANISOMETROPIC AMBLYOPIA ; VISUAL FUNCTIONS ; OLDER CHILDREN ; VERNIER ACUITY ; VIDEO GAME ; VISION ; STEREOACUITY |
WOS研究方向 | Neurosciences & Neurology |
WOS类目 | Neurosciences |
WOS记录号 | WOS:000597662800001 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/38210 |
专题 | 中国科学院行为科学重点实验室 |
通讯作者 | Huang, Chang-Bing; Yu, Minbin |
作者单位 | 1.Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou, Guangdong, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
通讯作者单位 | 中国科学院行为科学重点实验室 |
推荐引用方式 GB/T 7714 | Liu, Zitian,Chen, Zidong,Gao, Le,et al. A New Dichoptic Training Strategy Leads to Better Cooperation Between the Two Eyes in Amblyopia[J]. FRONTIERS IN NEUROSCIENCE,2020,14:14. |
APA | Liu, Zitian.,Chen, Zidong.,Gao, Le.,Liu, Manli.,Huang, Yiru.,...&Yu, Minbin.(2020).A New Dichoptic Training Strategy Leads to Better Cooperation Between the Two Eyes in Amblyopia.FRONTIERS IN NEUROSCIENCE,14,14. |
MLA | Liu, Zitian,et al."A New Dichoptic Training Strategy Leads to Better Cooperation Between the Two Eyes in Amblyopia".FRONTIERS IN NEUROSCIENCE 14(2020):14. |
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文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
A New Dichoptic Trai(2045KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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