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Antipsychotic Effects on Cortical Morphology in Schizophrenia and Bipolar Disorders
Feng, Ruiqi1,2; Womer, Fay Y.3; Edmiston, E. Kale4; Chen, Yifan2,5; Wang, Yinshan6,7; Chang, Miao1,2; Yin, Zhiyang2,5; Wei, Yange2,5; Duan, Jia2,5; Ren, Sihua1,2; Li, Chao1,2; Liu, Zhuang8; Jiang, Xiaowei1,2; Wei, Shengnan1,2; Li, Songbai1; Zhang, Xizhe9; Zuo, Xi-Nian10; Tang, Yanqing2,5; Wang, Fei1,2,5
Corresponding AuthorZuo, Xi-Nian(zuoxn@nnnu.edu.cn) ; Tang, Yanqing(yanqingtang@163.com) ; Wang, Fei(fei.wang@cmu.edu.cn)
AbstractBackground: Previous studies of atypical antipsychotic effects on cortical structures in schizophrenia (SZ) and bipolar disorder (BD) have findings that vary between the short and long term. In particular, there has not been a study exploring the effects of atypical antipsychotics on age-related cortical structural changes in SZ and BD. This study aimed to determine whether mid- to long-term atypical antipsychotic treatment (mean duration = 20 months) is associated with cortical structural changes and whether age-related cortical structural changes are affected by atypical antipsychotics. Methods: Structural magnetic resonance imaging images were obtained from 445 participants consisting of 88 medicated patients (67 with SZ, 21 with BD), 84 unmedicated patients (50 with SZ, 34 with BD), and 273 healthy controls (HC). Surface-based analyses were employed to detect differences in thickness and area among the three groups. We examined the age-related effects of atypical antipsychotics after excluding the potential effects of illness duration. Results: Significant differences in cortical thickness were observed in the frontal, temporal, parietal, and insular areas and the isthmus of the cingulate gyrus. The medicated group showed greater cortical thinning in these regions than the unmediated group and HC; furthermore, there were age-related differences in the effects of atypical antipsychotics, and these effects did not relate to illness duration. Moreover, cortical thinning was significantly correlated with lower symptom scores and Wisconsin Card Sorting Test (WCST) deficits in patients. After false discovery rate correction, cortical thinning in the right middle temporal gyrus in patients was significantly positively correlated with lower HAMD scores. The unmedicated group showed only greater frontotemporal thickness than the HC group. Conclusion: Mid- to long-term atypical antipsychotic use may adversely affect cortical thickness over the course of treatment and ageing and may also result in worsening cognitive function.
Keywordschizophrenia bipolar disorder atypical antipsychotics magnetic resonance imaging (MRI) cortical thickness
2020-12-10
Language英语
DOI10.3389/fnins.2020.579139
Source PublicationFRONTIERS IN NEUROSCIENCE
Volume14Pages:14
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[81571311] ; National Natural Science Foundation of China[81571331] ; National Key Research and Development Program[2018YFC1311604] ; National Key Research and Development Program[2016YFC1306900] ; National Key Research and Development Program[2016YFC0904300] ; National High Tech Development Plan (863)[2015AA020513] ; Liaoning Science and Technology Project[2015225018] ; Liaoning Education Foundation ; Innovation Team Support Plan of Higher Education of Liaoning Province[LT2017007] ; Major Special Construction plan of China Medical University[3110117059] ; Youth Backbone Support Program of China Medical University[QGZ2018034] ; National Natural Science Foundation of China: National Science Fund for Distinguished Young Scholars[81725005]
PublisherFRONTIERS MEDIA SA
WOS KeywordMAJOR PSYCHIATRIC-DISORDERS ; SURFACE-AREA ; BRAIN VOLUMES ; THICKNESS ; 1ST-EPISODE ; METAANALYSIS ; PSYCHOSIS ; DURATION ; IDENTIFICATION ; ABNORMALITIES
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000601258300001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/38266
Collection中国科学院行为科学重点实验室
Corresponding AuthorZuo, Xi-Nian; Tang, Yanqing; Wang, Fei
Affiliation1.China Med Univ, Dept Radiol, Affiliated Hosp 1, Shenyang, Peoples R China
2.China Med Univ, Brain Funct Res Sect, Affiliated Hosp 1, Shenyang, Peoples R China
3.Washington Univ, Sch Med, Dept Psychiat, St Louis, MO USA
4.Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA
5.China Med Univ, Dept Psychiat, Affiliated Hosp 1, Shenyang, Peoples R China
6.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
7.Inst Psychol, Res Ctr Lifespan Dev Mind & Brain CLIMB, Beijing, Peoples R China
8.China Med Univ, Sch Publ Hlth, Shenyang, Peoples R China
9.Nanjing Med Univ, Sch Biomed Engn & Informat, Nanjing, Peoples R China
10.Nanning Normal Univ, Sch Educ Sci, Key Lab Brain & Educ Sci, Nanning, Peoples R China
Recommended Citation
GB/T 7714
Feng, Ruiqi,Womer, Fay Y.,Edmiston, E. Kale,et al. Antipsychotic Effects on Cortical Morphology in Schizophrenia and Bipolar Disorders[J]. FRONTIERS IN NEUROSCIENCE,2020,14:14.
APA Feng, Ruiqi.,Womer, Fay Y..,Edmiston, E. Kale.,Chen, Yifan.,Wang, Yinshan.,...&Wang, Fei.(2020).Antipsychotic Effects on Cortical Morphology in Schizophrenia and Bipolar Disorders.FRONTIERS IN NEUROSCIENCE,14,14.
MLA Feng, Ruiqi,et al."Antipsychotic Effects on Cortical Morphology in Schizophrenia and Bipolar Disorders".FRONTIERS IN NEUROSCIENCE 14(2020):14.
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