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Deficits in ascending and descending pain modulation pathways in patients with postherpetic neuralgia
Li, Hong1,2; Li, Xiaoyun2,3; Feng, Yi4; Gao, Fei4; Kong, Yazhuo1,2; Hu, Li2,3
第一作者Li, Hong
通讯作者邮箱gaofei19780318@sina.com (f. gao) ; kongyz@psych.ac.cn (y. kong)
心理所单位排序1
摘要

Postherpetic Neuralgia (PHN), develops after the resolution of the herpes zoster mucocutaneous eruption, is a debilitating chronic pain. However, there is a lack of knowledge regarding the underlying mechanisms associated with ascending and descending pain modulations in PHN patients. Here, we combined psychophysics with structural and functional magnetic resonance imaging (MRI) techniques to investigate the brain alternations in PHN patients. Psychophysical tests showed that compared with healthy controls, PHN patients had increased state and trait anxiety and depression. Structural MRI data indicated that PHN patients had significantly smaller gray matter volumes of the thalamus and amygdala than healthy controls, and the thalamus volume was negatively correlated with pain intensity (assessed using the Short-form of the McGill pain questionnaire) in PHN patients. When the thalamus and periaqueductal gray matter (PAG) were used as the seeds, resting-state functional MRI data revealed abnormal patterns of functional connectivity within ascending and descending pain pathways in PHN patients, e.g., increased functional connectivity between the thalamus and somatosensory cortices and decreased functional connectivity between the PAG and frontal cortices. In addition, subjective ratings of both Present Pain Index (PPI) and Beck-Depression Inventory (BDI) were negatively correlated with the strength of functional connectivity between the PAG and primary somatosensory cortex (SI), and importantly, the effect of BDI on PPI was mediated by the PAG-SI functional connectivity. Overall, our results provided evidence suggesting deficits in ascending and descending pain modulation pathways, which were highly associated with the intensity of chronic pain and its emotional comorbidities in PHN patients. Therefore, our study deepened our understanding of the pathogenesis of PHN, which would be helpful in determining the optimized treatment for the patients.

关键词Postherpetic neuralgia Pain Thalamus Periaqueductal gray matter (PAG) Magnetic resonance imaging (MRI) Anxiety Depression
2020-11-01
语种英语
DOI10.1016/j.neuroimage.2020.117186
发表期刊NEUROIMAGE
ISSN1053-8119
卷号221页码:10
期刊论文类型实证研究
收录类别SCI
资助项目National Natural Science Foundation of China[31671141] ; National Natural Science Foundation of China[31822025] ; National Natural Science Foundation of China[81871436] ; Informatization Special Project of Chinese Academy of Sciences[XXH13506306] ; Scientific Foundation Project of Institute of Psychology, Chinese Academy of Sciences[Y6CX021008]
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS关键词BRAIN ACTIVITY ; GRAY-MATTER ; PERIAQUEDUCTAL GRAY ; CEREBRAL-CORTEX ; HERPES-ZOSTER ; DEFAULT-MODE ; CONNECTIVITY ; SEGMENTATION ; DEPRESSION ; ACCURATE
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000600795000051
引用统计
被引频次:37[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/38270
专题中国科学院行为科学重点实验室
通讯作者Gao, Fei; Kong, Yazhuo
作者单位1.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
3.Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
4.Peking Univ Peoples Hosp, Dept Pain Med, Beijing 100044, Peoples R China
第一作者单位中国科学院行为科学重点实验室
通讯作者单位中国科学院行为科学重点实验室
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GB/T 7714
Li, Hong,Li, Xiaoyun,Feng, Yi,et al. Deficits in ascending and descending pain modulation pathways in patients with postherpetic neuralgia[J]. NEUROIMAGE,2020,221:10.
APA Li, Hong,Li, Xiaoyun,Feng, Yi,Gao, Fei,Kong, Yazhuo,&Hu, Li.(2020).Deficits in ascending and descending pain modulation pathways in patients with postherpetic neuralgia.NEUROIMAGE,221,10.
MLA Li, Hong,et al."Deficits in ascending and descending pain modulation pathways in patients with postherpetic neuralgia".NEUROIMAGE 221(2020):10.
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