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Diabetes in late-life schizophrenia: Prevalence, factors, and association with clinical symptoms
Huo, Lijuan1,4; Lu, Xiaobing1,4; Wu, Fengchun1,4; Huang, Xingbing1,4; Ning, Yuping1,3,4; Zhang, Xiang Yang2
First AuthorHuo, Lijuan
Correspondent Emailningjeny@126.com (y. ning) ; zhangxy@psych.ac.cn (x.y. zhang)
Contribution Rank2
Abstract

Objective: The prevalence of diabetes mellitus has been found to be higher in patients with schizophrenia. Older patients are the fastest-growing segment of the schizophrenia population. However, few studies have explored diabetes in older patients with schizophrenia. Therefore, this study aimed to determine the prevalence and characteristics of factors associated with diabetes in Chinese patients with late-life schizophrenia (LLS), which has not been reported in previous studies. Methods: A total of 289 inpatients aged 60 or above who met the DSM-IV criteria for schizophrenia were recruited. The severity of psychopathology was assessed by the Positive and Negative Syndrome Scale (PANSS). Diabetes was diagnosed by fasting blood glucose tests, or oral glucose tolerance tests. Results: The overall prevalence of diabetes in LLS patients was 25.3%. The prevalence of diabetes in female patients was significantly higher than that in male patients (35% vs. 21.53%). Other factors associated with diabetes included higher BMI, greater waistline (only for males), higher levels of triglyceride, and more severe positive symptoms. Conclusion: These results indicate that the prevalence of diabetes in LLS patients is similar to that in the age matched general population. Female gender, excess weight and abdominal obesity, dyslipidemia, and clinical symptoms can be potential risk factors of diabetes in the LLS patient group.

KeywordLate-life schizophrenia Diabetes Prevalence Factors
2021
DOI10.1016/j.jpsychires.2020.09.026
Source PublicationJOURNAL OF PSYCHIATRIC RESEARCH
ISSN0022-3956
Volume132Pages:44-49
Subtype实证研究
Indexed BySCI
Funding ProjectScience and Technology Plan Project of Guangdong Province[2019B030316001] ; Guangzhou Municipal Psychiatric Disease Clinical Transformation Laboratory, Science and Technology Program of Guangzhou, China[201805010009] ; Guangzhou municipal key discipline in medicine (2017-2019) ; National Natural Science Foundation of China (NSFC)[31771074] ; Science and Technology Program of Guangzhou[201807010064] ; Science and Technology Program of Guangzhou[201704020168] ; Science and Technology Program of Guangzhou[201804010259] ; Scientific research project of traditional Chinese medicine of Guangdong[20192070] ; science and technology project of Liwan district[201804011]
PublisherPERGAMON-ELSEVIER SCIENCE LTD
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000598560300008
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/38298
Collection中国科学院心理健康重点实验室
Corresponding AuthorNing, Yuping; Zhang, Xiang Yang
Affiliation1.Guangzhou Med Univ, Guangzhou Huiai Hosp, Affiliated Brain Hosp, Dept Psychiat, 36 Mingxin Rd, Guangzhou 510000, Peoples R China
2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Guangzhou 100101, Peoples R China
3.Southern Med Univ, Sch Clin Med 1, Guangzhou 510000, Peoples R China
4.Guangdong Engn Technol Res Ctr Translat Med Menta, Guangzhou 510000, Peoples R China
Recommended Citation
GB/T 7714
Huo, Lijuan,Lu, Xiaobing,Wu, Fengchun,et al. Diabetes in late-life schizophrenia: Prevalence, factors, and association with clinical symptoms[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2021,132:44-49.
APA Huo, Lijuan,Lu, Xiaobing,Wu, Fengchun,Huang, Xingbing,Ning, Yuping,&Zhang, Xiang Yang.(2021).Diabetes in late-life schizophrenia: Prevalence, factors, and association with clinical symptoms.JOURNAL OF PSYCHIATRIC RESEARCH,132,44-49.
MLA Huo, Lijuan,et al."Diabetes in late-life schizophrenia: Prevalence, factors, and association with clinical symptoms".JOURNAL OF PSYCHIATRIC RESEARCH 132(2021):44-49.
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