Transcranial Direct Current Stimulation Enhances Episodic Memory in Healthy Older Adults by Modulating Retrieval-Specific Activation

doi:10.1155/2020/8883046

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	Transcranial Direct Current Stimulation Enhances Episodic Memory in Healthy Older Adults by Modulating Retrieval-Specific Activation
	Huo, Lijuan 1,2,3; Zheng, Zhiwei 1,3; Huang, Jia 1,3; Li, Rui 1,3; Li, Jin 4; Li, Juan 1,3
通讯作者	Li, Juan(lijuan@psych.ac.cn)
摘要	Memory decline has become an issue of major importance in the aging society. Anodal transcranial direct current stimulation (atDCS) is a viable tool to counteract age-associated episodic memory deterioration. However, the underlying neural mechanisms are unclear. In this single-blind, sham-controlled study, we combined atDCS and functional magnetic resonance imaging to assess the behavioral and neural consequences of multiple-session atDCS in older adults. Forty-nine healthy older adults received either 10 sessions of anodal or sham stimulation over the left dorsolateral prefrontal cortex. Before and after stimulation, participants performed a source memory task in the MRI scanner. Compared to sham stimulation, atDCS significantly improved item memory performance. Additionally, atDCS significantly increased regional brain activity around the stimulation area in the prefrontal cortex and extended to the bilateral anterior cingulate cortex. Neural changes in the prefrontal cortex correlated with memory gains. Our findings therefore indicate that multiple-session offline atDCS may improve memory in older adults by inducing neural alterations.
	2020-12-07
语种	英语
DOI	10.1155/2020/8883046
发表期刊	NEURAL PLASTICITY
ISSN	2090-5904
卷号	2020 页码:11
收录类别	SCI
资助项目	National Key Research and Development Program of China[2018YFC2000300] ; National Key Research and Development Program of China[2018YFC2001701] ; National Key Research and Development Program of China[2016YFC1305900] ; National Key Research and Development Program of China[2017YFB1401203] ; National Key Research and Development Program of China[2020YFC2003000] ; National Natural Science Foundation of China[32071079] ; National Natural Science Foundation of China[31861133011] ; National Natural Science Foundation of China[31671157] ; National Natural Science Foundation of China[31711530157] ; National Natural Science Foundation of China[31470998] ; National Natural Science Foundation of China[31700974] ; National Natural Science Foundation of China[61673374] ; Beijing Municipal Science and Technology Commission[Z171100008217006] ; Beijing Municipal Science and Technology Commission[Z171100000117006] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2020089]
出版者	HINDAWI LTD
WOS关键词	MEDIAL TEMPORAL-LOBE ; PREFRONTAL CORTEX ; FUNCTIONAL CONNECTIVITY ; BRAIN-STIMULATION ; PARIETAL CORTEX ; TDCS ; FACILITATION ; FAMILIARITY ; PERFORMANCE ; NETWORKS
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000601175600001
资助机构	National Key Research and Development Program of China ; National Natural Science Foundation of China ; Beijing Municipal Science and Technology Commission ; Youth Innovation Promotion Association of the Chinese Academy of Sciences
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/38327
通讯作者	Li, Juan
作者单位	1.Chinese Acad Sci, Inst Psychol, Ctr Aging Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Guangzhou Med Univ, Dept Psychiat, Affiliated Brain Hosp, Guangzhou Huiai Hosp, Guangzhou, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Inner Mongolia Mental Hlth Ctr, Inner Mongolia, Peoples R China
推荐引用方式 GB/T 7714	Huo, Lijuan,Zheng, Zhiwei,Huang, Jia,et al. Transcranial Direct Current Stimulation Enhances Episodic Memory in Healthy Older Adults by Modulating Retrieval-Specific Activation[J]. NEURAL PLASTICITY,2020,2020:11.
APA	Huo, Lijuan,Zheng, Zhiwei,Huang, Jia,Li, Rui,Li, Jin,&Li, Juan.(2020).Transcranial Direct Current Stimulation Enhances Episodic Memory in Healthy Older Adults by Modulating Retrieval-Specific Activation.NEURAL PLASTICITY,2020,11.
MLA	Huo, Lijuan,et al."Transcranial Direct Current Stimulation Enhances Episodic Memory in Healthy Older Adults by Modulating Retrieval-Specific Activation".NEURAL PLASTICITY 2020(2020):11.