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Transcranial Direct Current Stimulation Enhances Episodic Memory in Healthy Older Adults by Modulating Retrieval-Specific Activation
Huo, Lijuan1,2,3; Zheng, Zhiwei1,3; Huang, Jia1,3; Li, Rui1,3; Li, Jin4; Li, Juan1,3
Corresponding AuthorLi, Juan(lijuan@psych.ac.cn)
AbstractMemory decline has become an issue of major importance in the aging society. Anodal transcranial direct current stimulation (atDCS) is a viable tool to counteract age-associated episodic memory deterioration. However, the underlying neural mechanisms are unclear. In this single-blind, sham-controlled study, we combined atDCS and functional magnetic resonance imaging to assess the behavioral and neural consequences of multiple-session atDCS in older adults. Forty-nine healthy older adults received either 10 sessions of anodal or sham stimulation over the left dorsolateral prefrontal cortex. Before and after stimulation, participants performed a source memory task in the MRI scanner. Compared to sham stimulation, atDCS significantly improved item memory performance. Additionally, atDCS significantly increased regional brain activity around the stimulation area in the prefrontal cortex and extended to the bilateral anterior cingulate cortex. Neural changes in the prefrontal cortex correlated with memory gains. Our findings therefore indicate that multiple-session offline atDCS may improve memory in older adults by inducing neural alterations.
2020-12-07
Language英语
DOI10.1155/2020/8883046
Source PublicationNEURAL PLASTICITY
ISSN2090-5904
Volume2020Pages:11
Indexed BySCI
Funding ProjectNational Key Research and Development Program of China[2018YFC2000300] ; National Key Research and Development Program of China[2018YFC2001701] ; National Key Research and Development Program of China[2016YFC1305900] ; National Key Research and Development Program of China[2017YFB1401203] ; National Key Research and Development Program of China[2020YFC2003000] ; National Natural Science Foundation of China[32071079] ; National Natural Science Foundation of China[31861133011] ; National Natural Science Foundation of China[31671157] ; National Natural Science Foundation of China[31711530157] ; National Natural Science Foundation of China[31470998] ; National Natural Science Foundation of China[31700974] ; National Natural Science Foundation of China[61673374] ; Beijing Municipal Science and Technology Commission[Z171100008217006] ; Beijing Municipal Science and Technology Commission[Z171100000117006] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2020089]
PublisherHINDAWI LTD
WOS KeywordMEDIAL TEMPORAL-LOBE ; PREFRONTAL CORTEX ; FUNCTIONAL CONNECTIVITY ; BRAIN-STIMULATION ; PARIETAL CORTEX ; TDCS ; FACILITATION ; FAMILIARITY ; PERFORMANCE ; NETWORKS
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000601175600001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/38329
Collection中国科学院心理健康重点实验室
Corresponding AuthorLi, Juan
Affiliation1.Chinese Acad Sci, Inst Psychol, Ctr Aging Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Guangzhou Med Univ, Dept Psychiat, Affiliated Brain Hosp, Guangzhou Huiai Hosp, Guangzhou, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Inner Mongolia Mental Hlth Ctr, Inner Mongolia, Peoples R China
Recommended Citation
GB/T 7714
Huo, Lijuan,Zheng, Zhiwei,Huang, Jia,et al. Transcranial Direct Current Stimulation Enhances Episodic Memory in Healthy Older Adults by Modulating Retrieval-Specific Activation[J]. NEURAL PLASTICITY,2020,2020:11.
APA Huo, Lijuan,Zheng, Zhiwei,Huang, Jia,Li, Rui,Li, Jin,&Li, Juan.(2020).Transcranial Direct Current Stimulation Enhances Episodic Memory in Healthy Older Adults by Modulating Retrieval-Specific Activation.NEURAL PLASTICITY,2020,11.
MLA Huo, Lijuan,et al."Transcranial Direct Current Stimulation Enhances Episodic Memory in Healthy Older Adults by Modulating Retrieval-Specific Activation".NEURAL PLASTICITY 2020(2020):11.
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