Institutional Repository, Institute of Psychology, Chinese Academy of Sciences
Oxytocin modulates human chemosensory decoding of sex in a dose-dependent manner | |
Chen, Kepu1; Ye, Yuting2; Troje, Nikolaus F.3; Zhou, Wen1,2,4 | |
第一作者 | Chen, Kepu |
通讯作者邮箱 | zhouw@psych.ac.cn (wen zhou ) |
心理所单位排序 | 4 |
摘要 | There has been accumulating evidence of human social chemo-signaling, but the underlying mechanisms remain poorly understood. Considering the evolutionarily conserved roles of oxytocin and vasopressin in reproductive and social behaviors, we examined whether the two neuropeptides are involved in the subconscious processing of androsta-4,16,-dien-3-one and estra-1,3,5 (10),16-tetraen-3-ol, two human chemosignals that convey masculinity and femininity to the targeted recipients, respectively. Psychophysical data collected from 216 heterosexual and homosexual men across five experiments totaling 1056 testing sessions consistently showed that such chemosensory communications of masculinity and femininity were blocked by a competitive antagonist of both oxytocin and vasopressin receptors called atosiban, administered nasally. On the other hand, intranasal oxytocin, but not vasopressin, modulated the decoding of androstadienone and estratetraenol in manners that were dose-dependent, nonmonotonic, and contingent upon the recipients' social proficiency. Taken together, these findings establish a causal link between neuroendocrine factors and subconscious chemosensory communications of sex-specific information in humans. |
2021-01-13 | |
语种 | 英语 |
DOI | 10.7554/eLife.59376 |
发表期刊 | ELIFE |
ISSN | 2050-084X |
卷号 | 10页码:18 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China[31830037] ; National Natural Science Foundation of China[31422023] ; National Natural Science Foundation of China[QYZDB-SSW-SMC055] ; National Natural Science Foundation of China[XDB32010200] |
出版者 | ELIFE SCIENCES PUBLICATIONS LTD |
WOS关键词 | INDIVIDUAL-DIFFERENCES ; PUTATIVE PHEROMONES ; SOCIAL RECOGNITION ; BRAIN RESPONSE ; HORMONE ; CHEMOSIGNALS ; INTRANASAL ; AUTISM ; VASOPRESSIN ; PLASMA |
WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
WOS类目 | Biology |
WOS记录号 | WOS:000610884200001 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/38477 |
专题 | 脑与认知科学国家重点实验室 |
通讯作者 | Zhou, Wen |
作者单位 | 1.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Psychol, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.York Univ, Ctr Vis Res, Toronto, ON, Canada 4.Chinese Inst Brain Res, Beijing, Peoples R China |
第一作者单位 | 脑与认知科学国家重点实验室 |
通讯作者单位 | 脑与认知科学国家重点实验室 |
推荐引用方式 GB/T 7714 | Chen, Kepu,Ye, Yuting,Troje, Nikolaus F.,et al. Oxytocin modulates human chemosensory decoding of sex in a dose-dependent manner[J]. ELIFE,2021,10:18. |
APA | Chen, Kepu,Ye, Yuting,Troje, Nikolaus F.,&Zhou, Wen.(2021).Oxytocin modulates human chemosensory decoding of sex in a dose-dependent manner.ELIFE,10,18. |
MLA | Chen, Kepu,et al."Oxytocin modulates human chemosensory decoding of sex in a dose-dependent manner".ELIFE 10(2021):18. |
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