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The prevalence and related factors of metabolic syndrome in outpatients with first-episode drug-naive major depression comorbid with anxiety
Zhong, Yinghua1; Hu, Manji1; Wang, Qiang1; Yang, Zhendong1; Zhu, Na1; Wang, Fei1; Zhang, Xiyan1; Zhang, Chengfang1; Min, Jie1; Wang, Hao1; Chen, Fazhan1; Zhao, Xudong1,2; Zhang, Xiangyang3,4
First AuthorZhong, Yinghua
Correspondent Emailzhaoxd@tongji.edu.cn (xudong zhao) ; zhangxy@psych.ac.cn (xiangyang zhang)
Contribution Rank3
Abstract

Metabolic syndrome (MetS) is associated with depression, but its role in major depressive disorder comorbid with anxiety (AMD) is unclear. This study aimed to investigate the prevalence and clinical correlates of MetS in first-episode drug-naive (FEDN) patients with AMD in a Chinese Han population. In total, 1380 FEDN outpatients with AMD were recruited in this cross-sectional study. The sociodemographic features, clinical characteristics, history of suicide attempts, thyroid-stimulating hormone (TSH) levels, and MetS parameters of each subject were evaluated. All subjects were rated on the Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Rating Scale (HAM-A), and the Positive and Negative Syndrome Scale positive symptom subscale. The prevalence of MetS among AMD patients was 8.04%. Compared to the non-MetS group, age, age of onset, TSH level, HAM-A and HAM-D scores, history of attempted suicide, and comorbid psychiatric symptoms were higher in the MetS group. Those in this group were also more likely to be married, and they had a lower educational level. Furthermore, age, psychiatric symptoms, suicide attempts, and higher TSH levels were independently associated with MetS in AMD patients. This study suggests a lower prevalence of MetS in FEDN patients with AMD in a Chinese Han population. Older age, comorbid psychiatric symptoms, history of attempted suicide, and higher TSH levels are related factors for MetS in AMD patients.

2021-02-08
DOI10.1038/s41598-021-81653-2
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume11Issue:1Pages:9
Subtype实证研究
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[81771464] ; Training Plan of Health System Academic Leader of the Shanghai Pudong Municipality Health Commission[PWRd2019-08] ; Outstanding Clinical Discipline Project of Shanghai Pudong[PWYgy2018-10] ; Hospital Level Project of Shanghai Pudong New Area Mental Health Center[PDJWM201903] ; General Project of the Shanghai Municipality Health Commission[202040475]
PublisherNATURE RESEARCH
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000617646300009
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/38547
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhao, Xudong; Zhang, Xiangyang
Affiliation1.Tongji Univ, Shanghai Pudong New Area Mental Hlth Ctr, Sch Med, Shanghai, Peoples R China
2.Tongji Univ, Sch Med, Div Med Humanities & Behav Sci, 1239 Siping Rd,Postbox 244, Shanghai 200092, Peoples R China
3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Zhong, Yinghua,Hu, Manji,Wang, Qiang,et al. The prevalence and related factors of metabolic syndrome in outpatients with first-episode drug-naive major depression comorbid with anxiety[J]. SCIENTIFIC REPORTS,2021,11(1):9.
APA Zhong, Yinghua.,Hu, Manji.,Wang, Qiang.,Yang, Zhendong.,Zhu, Na.,...&Zhang, Xiangyang.(2021).The prevalence and related factors of metabolic syndrome in outpatients with first-episode drug-naive major depression comorbid with anxiety.SCIENTIFIC REPORTS,11(1),9.
MLA Zhong, Yinghua,et al."The prevalence and related factors of metabolic syndrome in outpatients with first-episode drug-naive major depression comorbid with anxiety".SCIENTIFIC REPORTS 11.1(2021):9.
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