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P50 inhibition defects with psychopathology and cognitive impairment in patients with first-episode drug naive schizophrenia
Xia, Luyao1,2; Wang, Dongmei1,2; Wei, Gaoxia1,2; Wang, Jiesi1,2; Zhou, Huixia1,2; Xu, Hang1,2; Tian, Yang1,2; Dai, Qilong1,2; Xiu, Meihong3; Chen, Dachun3; Wang, Li1,2; Zhang, Xiangyang1,2
First AuthorXia, Luyao
Correspondent Emailzhangxy@psych.ac.cn (x. zhang)
Contribution Rank1
Abstract

Background: Many studies have announced that P50 inhibition defects represent sensory gating deficits in schizophrenia, but studies seldom have searched the correlation between P50 inhibition defects and the psychopathology or cognitive impairment of patients with first-episode, drug naive (FEDN) of schizophrenia. In this study, we investigated the auditory sensory gating deficits in a large number of Han patients with FEDN schizophrenia and their correlation with clinical symptoms and cognitive impairment. Methods: A total of 130 patients with FEDN schizophrenia and 189 healthy controls were recruited in this study. Positive and Negative Syndrome Scale (PANSS) and its five-factor model were used to score the psychopathology of the patients, and P50 inhibition was recorded using the 64-channel electroencephalography (EEG) system. Results: Patients exhibited significantly longer S1 and S2 latency, lower S1 and S2 amplitudes and lower P50 difference than healthy controls (all p < 0.05). Significant correlations existed between S1 latency and PANSS negative symptoms or cognitive factor, P50 ratio and general psychopathology, P50 ratio and PANSS total score, P50 difference and general psychopathology, and P50 difference and PANSS total score (all p < 0.05). Multiple regression analysis revealed that S1 latency, sex, age, and education were contributors to negative symptom score (all p < 0.05). S1 latency, S2 latency, sex, age, and smoking status were contributors to cognitive factor (all p < 0.05). Conclusions: Our results show that patients with FEDN schizophrenia have P50 inhibition defects, which may be related to their psychopathological symptoms and cognitive impairment.

KeywordSchizophrenia P50 Sensory gating Auditory evoked potential Cognition
2021-04-20
DOI10.1016/j.pnpbp.2021.110246
Source PublicationPROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
ISSN0278-5846
Volume107Pages:7
Subtype实证研究
Indexed BySCI
PublisherPERGAMON-ELSEVIER SCIENCE LTD
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS SubjectClinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS IDWOS:000617280700016
WoS QuartileQ1
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/38569
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhang, Xiangyang
Affiliation1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Peking Univ, Beijing HuiLongGuan Hosp, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Xia, Luyao,Wang, Dongmei,Wei, Gaoxia,et al. P50 inhibition defects with psychopathology and cognitive impairment in patients with first-episode drug naive schizophrenia[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2021,107:7.
APA Xia, Luyao.,Wang, Dongmei.,Wei, Gaoxia.,Wang, Jiesi.,Zhou, Huixia.,...&Zhang, Xiangyang.(2021).P50 inhibition defects with psychopathology and cognitive impairment in patients with first-episode drug naive schizophrenia.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,107,7.
MLA Xia, Luyao,et al."P50 inhibition defects with psychopathology and cognitive impairment in patients with first-episode drug naive schizophrenia".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 107(2021):7.
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