Eight-week antidepressant treatment reduces functional connectivity in first-episode drug-naive patients with major depressive disorder

doi:10.1002/hbm.25391

PSYCH OpenIR

	Eight-week antidepressant treatment reduces functional connectivity in first-episode drug-naive patients with major depressive disorder
	Li, Le 1,2; Su, Yun-Ai 3,4; Wu, Yan-Kun 3,4; Castellanos, Francisco Xavier 5,6; Li, Ke 7; Li, Ji-Tao 3,4; Si, Tian-Mei 3,4; Yan, Chao-Gan 1,8,9,10
通讯作者	Si, Tian-Mei(si.tian-mei@163.com) ; Yan, Chao-Gan(yancg@psych.ac.cn)
摘要	Previous neuroimaging studies have revealed abnormal functional connectivity of brain networks in patients with major depressive disorder (MDD), but findings have been inconsistent. A recent big-data study found abnormal intrinsic functional connectivity within the default mode network in patients with recurrent MDD but not in first-episode drug-naive patients with MDD. This study also provided evidence for reduced default mode network functional connectivity in medicated MDD patients, raising the question of whether previously observed abnormalities may be attributable to antidepressant effects. The present study ( identifier: NCT03294525) aimed to disentangle the effects of antidepressant treatment from the pathophysiology of MDD and test the medication normalization hypothesis. Forty-one first-episode drug-naive MDD patients were administrated antidepressant medication (escitalopram or duloxetine) for 8 weeks, with resting-state functional connectivity compared between posttreatment and baseline. To assess the replicability of the big-data finding, we also conducted a cross-sectional comparison of resting-state functional connectivity between the MDD patients and 92 matched healthy controls. Both Network-Based Statistic analyses and large-scale network analyses revealed intrinsic functional connectivity decreases in extensive brain networks after treatment, indicating considerable antidepressant effects. Neither Network-Based Statistic analyses nor large-scale network analyses detected significant functional connectivity differences between treatment-naive patients and healthy controls. In short, antidepressant effects are widespread across most brain networks and need to be accounted for when considering functional connectivity abnormalities in MDD.
关键词	antidepressants brain network functional connectivity major depressive disorder resting‐ state fMRI
	2021-02-27
语种	英语
DOI	10.1002/hbm.25391
发表期刊	HUMAN BRAIN MAPPING
ISSN	1065-9471
页码	13
收录类别	SCI
资助项目	National Key R&D Program of China[2017YFC1309902] ; Beijing Municipal Science and Technology Project[Z171100000117016] ; Beijing Nova Program of Science and Technology[Z191100001119104] ; Capital Medical Development Research Fund[2016-1-4111] ; The 13th Five-year Informatization Plan of Chinese Academy of Sciences[XXH13505] ; Key Research Program of the Chinese Academy of Sciences[ZDBS-SSW-JSC006] ; National Key Technology RD Program[2015BAI13B01] ; National Natural Science Foundation of China[81630031] ; National Natural Science Foundation of China[81671774]
出版者	WILEY
WOS研究方向	Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000622323300001
资助机构	National Key R&D Program of China ; Beijing Municipal Science and Technology Project ; Beijing Nova Program of Science and Technology ; Capital Medical Development Research Fund ; The 13th Five-year Informatization Plan of Chinese Academy of Sciences ; Key Research Program of the Chinese Academy of Sciences ; National Key Technology RD Program ; National Natural Science Foundation of China
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/38582
通讯作者	Si, Tian-Mei; Yan, Chao-Gan
作者单位	1.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China 2.Beijing Language & Culture Univ, Ctr Cognit Sci Language, Beijing, Peoples R China 3.Peking Univ, Peking Univ Sixth Hosp, Inst Mental Hlth, Beijing, Peoples R China 4.Peking Univ, Peking Univ Sixth Hosp, Natl Clin Res Ctr Mental Disorders, NHC Key Lab Mental Hlth, Beijing, Peoples R China 5.NYU Grossman Sch Med, Dept Child & Adolescent Psychiat, New York, NY USA 6.Nathan S Kline Inst Psychiat Res, Orangeburg, NY USA 7.Peoples Liberat Army, Hosp 306, Dept Radiol, Beijing, Peoples R China 8.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Inst Psychol, Beijing, Peoples R China 9.Chinese Acad Sci, Int Big Data Ctr Depress Res, Inst Psychol, Beijing, Peoples R China 10.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Li, Le,Su, Yun-Ai,Wu, Yan-Kun,et al. Eight-week antidepressant treatment reduces functional connectivity in first-episode drug-naive patients with major depressive disorder[J]. HUMAN BRAIN MAPPING,2021:13.
APA	Li, Le.,Su, Yun-Ai.,Wu, Yan-Kun.,Castellanos, Francisco Xavier.,Li, Ke.,...&Yan, Chao-Gan.(2021).Eight-week antidepressant treatment reduces functional connectivity in first-episode drug-naive patients with major depressive disorder.HUMAN BRAIN MAPPING,13.
MLA	Li, Le,et al."Eight-week antidepressant treatment reduces functional connectivity in first-episode drug-naive patients with major depressive disorder".HUMAN BRAIN MAPPING (2021):13.