Diabetes mellitus, cognitive deficits and serum BDNF levels in chronic patients with schizophrenia: A case-control study

doi:10.1016/j.jpsychires.2020.12.035

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	Diabetes mellitus, cognitive deficits and serum BDNF levels in chronic patients with schizophrenia: A case-control study
	Li, Shen 1,2; Chen, Dachun 3; Xiu, Meihong 3; Li, Jie 2; Zhang, Xiang Yang 4,5
通讯作者	Li, Jie(jieli@tjmhc.com) ; Zhang, Xiang Yang(zhangxy@psych.ac.cn)
摘要	The relationship between serum BDNF levels and cognitive dysfunction in schizophrenia (SCZ) patients comorbid with type 2 diabetes mellitus (T2DM) has not been reported. Hence, this study aimed to explore whether and how the changes of serum BDNF levels were correlated with cognitive impairment in SCZ patients comorbid with T2DM. We recruited 472 inpatients with chronic SCZ (54 T2DM and 418 non-T2DM), and 225 healthy controls. Serum BDNF levels and routine biochemical parameters were measured. Psychopathological symptoms were evaluated by the Positive and Negative Syndrome Scale (PANSS) and cognitive function was assessed by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). SCZ patients with T2DM had significantly higher serum BDNF levels than SCZ patients without T2DM (F = 11.31, p = 0.001). SCZ patients with T2DM scored higher in delayed memory than SCZ patients without T2DM (77.17 +/- 18.44 vs.66.24 +/- 19.51, p = 0.000), and still showed significance after controlling for confounders. Further stepwise multiple regression analysis identified serum BDNF as an independent contributor to the RBANS attention of SCZ patients with T2DM (beta = 0.30, t = 2.09, p = 0.042). The increase of BDNF levels and better cognitive performance, especially delayed memory, may be related to the pathophysiological process of T2DM in chronic SCZ patients.
关键词	BDNF Cognition Schizophrenia Diabetes Correlation
	2021-02-01
语种	英语
DOI	10.1016/j.jpsychires.2020.12.035
发表期刊	JOURNAL OF PSYCHIATRIC RESEARCH
ISSN	0022-3956
卷号	134 页码:39-47
收录类别	SCI
资助项目	National Natural Science Foundation of China[81801323] ; Tianjin Key Project for Chronic Disease Prevention[17ZXMFSY00070] ; Tianjin Key Discipline Project for Psychiatry
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:000616251600007
资助机构	National Natural Science Foundation of China ; Tianjin Key Project for Chronic Disease Prevention ; Tianjin Key Discipline Project for Psychiatry
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/38588
通讯作者	Li, Jie; Zhang, Xiang Yang
作者单位	1.Tianjin Med Univ, Dept Psychiat, Coll Basic Med Sci, Tianjin 300070, Peoples R China 2.Tianjin Med Univ, Inst Mental Hlth, Tianjin Anding Hosp, Lab Biol Psychiat, Tianjin 300222, Peoples R China 3.Peking Univ, Beijing HuiLongGuan Hosp, HuiLongGuan Clin Med Sch, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Li, Shen,Chen, Dachun,Xiu, Meihong,et al. Diabetes mellitus, cognitive deficits and serum BDNF levels in chronic patients with schizophrenia: A case-control study[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2021,134:39-47.
APA	Li, Shen,Chen, Dachun,Xiu, Meihong,Li, Jie,&Zhang, Xiang Yang.(2021).Diabetes mellitus, cognitive deficits and serum BDNF levels in chronic patients with schizophrenia: A case-control study.JOURNAL OF PSYCHIATRIC RESEARCH,134,39-47.
MLA	Li, Shen,et al."Diabetes mellitus, cognitive deficits and serum BDNF levels in chronic patients with schizophrenia: A case-control study".JOURNAL OF PSYCHIATRIC RESEARCH 134(2021):39-47.