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Tracking Response Dynamics of Sequential Working Memory in Patients With Mild Parkinson's Disease
Zhang, Guanyu1,2; Ma, Jinghong3; Chan, Piu4; Ye, Zheng5,6
First AuthorZhang, Guanyu
Correspondent Emailyez@ion.ac.cn (zheng ye)
Contribution Rank1
Abstract

The ability to sequence thoughts and actions is impaired in Parkinson's disease (PD). In PD, a distinct error pattern has been found in the offline performance of sequential working memory. This study examined how PD's performance of sequential working memory unfolds over time using mouse tracking techniques. Non-demented patients with mild PD (N = 40) and healthy controls (N = 40) completed a computerized digit ordering task with a computer mouse. We measured response dynamics in terms of the initiation time, ordering time, movement time, and area under the movement trajectory curve. This approach allowed us to distinguish between the cognitive processes related to sequence processing before the actual movement (initiation time and ordering time) and the execution processes of the actual movement (movement time and area under the curve). PD patients showed longer initiation times, longer movement times, and more constrained movement trajectories than healthy controls. The initiation time and ordering time negatively correlated with the daily exposure to levodopa and D2/3 receptor agonists, respectively. The movement time positively correlated with the severity of motor symptoms. We demonstrated an altered temporal profile of sequential working memory in PD. Stimulating D1 and D2/3 receptors might speed up the maintenance and manipulation of sequences, respectively.

KeywordParkinson’ s disease dopamine sequential working memory mouse tracking dopamine D2 receptor agonist
2021-02-19
DOI10.3389/fpsyg.2021.631672
Source PublicationFRONTIERS IN PSYCHOLOGY
ISSN1664-1078
Volume12Pages:8
Subtype实证研究
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[31771216] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX05] ; National Key Research and Development Program of China[2018YFC1312001]
PublisherFRONTIERS MEDIA SA
WOS Research AreaPsychology
WOS SubjectPsychology, Multidisciplinary
WOS IDWOS:000625299500001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/38626
Collection健康与遗传心理学研究室
Corresponding AuthorYe, Zheng
Affiliation1.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Capital Med Univ, Dept Neurol, Xuanwu Hosp, Beijing, Peoples R China
4.Capital Med Univ, Dept Neurol & Neurobiol, Natl Clin Res Ctr Geriatr Disorders, Xuanwu Hosp, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Neurosci, Ctr Excellence Brain Sci & Intelligence Technol, Key Lab Primate Neurobiol, Shanghai, Peoples R China
6.Shanghai Ctr Brain Sci & Brain Inspired Intellige, Shanghai, Peoples R China
First Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhang, Guanyu,Ma, Jinghong,Chan, Piu,et al. Tracking Response Dynamics of Sequential Working Memory in Patients With Mild Parkinson's Disease[J]. FRONTIERS IN PSYCHOLOGY,2021,12:8.
APA Zhang, Guanyu,Ma, Jinghong,Chan, Piu,&Ye, Zheng.(2021).Tracking Response Dynamics of Sequential Working Memory in Patients With Mild Parkinson's Disease.FRONTIERS IN PSYCHOLOGY,12,8.
MLA Zhang, Guanyu,et al."Tracking Response Dynamics of Sequential Working Memory in Patients With Mild Parkinson's Disease".FRONTIERS IN PSYCHOLOGY 12(2021):8.
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