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The effect of effort-reward imbalance on brain structure and resting-state functional connectivity in individuals with high levels of schizotypal traits
Yan, Yong-jie1,2,3; Huang, Jia1,4; Lui, Simon S. Y.5,8; Cheung, Eric F. C.5; Madsen, Kristoffer H.2,3,6,7; Chan, Raymond C. K.1,2,3,4
Correspondent Emailhuangj@psych.ac.cn (jia huang )
Abstract

Introduction Effort-reward imbalance (ERI) is a typical psychosocial stress. Schizotypal traits are attenuated features of schizophrenia in the general population. According to the diathesis-stress model, schizotypal traits and psychosocial stress contribute to the onset of schizophrenia. However, few studies examined the effects of these factors on brain alterations. This study aimed to examine relationships between ERI, schizotypal traits and brain structures and functions. Methods We recruited 37 (13 male, 24 female) participants with high levels of schizotypal traits and 36 (12 male, 24 female) participants with low levels of schizotypal traits by the Schizotypal Personality Questionnaire (SPQ). The Chinese school version of the effort-reward imbalance questionnaire (C-ERI-S) was used to measure ERI. We conducted the voxel-based morphometry (VBM) and whole brain resting-state functional connectivity (rsFC) analysis using reward or stress-related regions as seeds. Results Participants with high levels of schizotypal traits were more likely to perceive ERI. The severity of ERI was correlated with grey matter volume (GMV) reduction of the left pallidum and altered rsFC among the prefrontal, striatum and cerebellum in participants with high levels of schizotypal traits. Conclusion ERI is associated with GMV reduction and altered rsFC in individuals with high levels of schizotypal traits.

KeywordEffort-reward imbalance schizotypal traits voxel-based morphometry resting-state functional connectivity
2021-03-12
DOI10.1080/13546805.2021.1899906
Source PublicationCOGNITIVE NEUROPSYCHIATRY
ISSN1354-6805
Pages17
Subtype实证研究
Indexed BySCI
Funding ProjectNational Key Research and Development Programme[2016YFC0906402] ; National Natural Science Foundation of China[31100747] ; Beijing Training Project for Leading Talents in ST[Z151100000315020] ; CAS Key Laboratory of Mental Health of Institute of Psychology
PublisherROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000628064000001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/38630
Collection中国科学院心理健康重点实验室
Corresponding AuthorHuang, Jia; Chan, Raymond C. K.
Affiliation1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
2.Chinese Acad Sci, Sino Danish Coll, Beijing, Peoples R China
3.Sino Danish Ctr Educ & Res, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
5.Castle Peak Hosp, Hong Kong, Peoples R China
6.Copenhagen Univ Hosp Hvidovre, Ctr Funct & Diagnost Imaging & Res, Danish Res Ctr Magnet Resonance, Hvidovre, Denmark
7.Tech Univ Denmark, Dept Appl Math & Comp Sci, Lyngby, Denmark
8.Univ Hong Kong, Dept Psychiat, Hong Kong, Peoples R China
First Author Affilication认知与发展心理学研究室
Corresponding Author Affilication认知与发展心理学研究室
Recommended Citation
GB/T 7714
Yan, Yong-jie,Huang, Jia,Lui, Simon S. Y.,et al. The effect of effort-reward imbalance on brain structure and resting-state functional connectivity in individuals with high levels of schizotypal traits[J]. COGNITIVE NEUROPSYCHIATRY,2021:17.
APA Yan, Yong-jie,Huang, Jia,Lui, Simon S. Y.,Cheung, Eric F. C.,Madsen, Kristoffer H.,&Chan, Raymond C. K..(2021).The effect of effort-reward imbalance on brain structure and resting-state functional connectivity in individuals with high levels of schizotypal traits.COGNITIVE NEUROPSYCHIATRY,17.
MLA Yan, Yong-jie,et al."The effect of effort-reward imbalance on brain structure and resting-state functional connectivity in individuals with high levels of schizotypal traits".COGNITIVE NEUROPSYCHIATRY (2021):17.
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