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Negative Parenting Affects Adolescent Internalizing Symptoms Through Alterations in Amygdala-Prefrontal Circuitry: A Longitudinal Twin Study
Jiang, Nengzhi1,2,4; Xu, Jiahua3,5,6,7; Li, Xinying1,4; Wang, Yanyu2; Zhuang, Liping3,5,6,7; Qin, Shaozheng3,5,6,7
第一作者Jiang, Nengzhi
心理所单位排序1
摘要

BACKGROUND: The synergic interaction of risk genes and environmental factors has been thought to play a critical role in mediating emotion-related brain circuitry function and dysfunction in depression and anxiety disorders. Little, however, is known regarding neurodevelopmental bases underlying how maternal negative parenting affects emotion-related brain circuitry linking to adolescent internalizing symptoms and whether this neurobehavioral association is heritable during adolescence. METHODS: The effects of maternal parenting on amygdala-based emotional circuitry and internalizing symptoms were examined by using longitudinal functional magnetic resonance imaging among 100 monozygotic twins and 78 dizygotic twins from early adolescence (age 13 years) to mid-adolescence (age 16 years). The mediation effects among variables of interest and their heritability were assessed by structural equation modeling and quantitative genetic analysis, respectively. RESULTS: Exposure to maternal negative parenting was positively predictive of stronger functional connectivity of the amygdala with the ventrolateral prefrontal cortex. This neural pathway mediated the association between negative parenting and adolescent depressive symptoms and exhibited moderate heritability (21%). CONCLUSIONS: These findings highlight that maternal negative parenting in early adolescence is associated with the development of atypical amygdala-prefrontal connectivity in relation to internalizing depressive symptoms in midadolescence. Such abnormality of emotion-related brain circuitry is heritable to a moderate degree.

2021-03-15
DOI10.1016/j.biopsych.2020.08.002
发表期刊BIOLOGICAL PSYCHIATRY
ISSN0006-3223
卷号89期号:6页码:560-569
期刊论文类型实证研究
收录类别SCI
资助项目National Natural Science Foundation of China[31530031] ; National Natural Science Foundation of China[31522028] ; National Natural Science Foundation of China[81571056] ; Medical Science Foundation of Shandong Province[2017WS759] ; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning in China[CNLZD1503]
出版者ELSEVIER SCIENCE INC
WOS研究方向Neurosciences & Neurology ; Psychiatry
WOS类目Neurosciences ; Psychiatry
WOS记录号WOS:000618784800008
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/38645
专题中国科学院心理健康重点实验室
通讯作者Li, Xinying; Qin, Shaozheng
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
2.Weifang Med Univ, Sch Psychol, Weifang, Peoples R China
3.Chinese Inst Brain Res, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
5.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China
6.Beijing Normal Univ, Beijing Key Lab Brain Imaging & Connect, Beijing, Peoples R China
7.Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing, Peoples R China
第一作者单位中国科学院心理健康重点实验室
通讯作者单位中国科学院心理健康重点实验室
推荐引用方式
GB/T 7714
Jiang, Nengzhi,Xu, Jiahua,Li, Xinying,et al. Negative Parenting Affects Adolescent Internalizing Symptoms Through Alterations in Amygdala-Prefrontal Circuitry: A Longitudinal Twin Study[J]. BIOLOGICAL PSYCHIATRY,2021,89(6):560-569.
APA Jiang, Nengzhi,Xu, Jiahua,Li, Xinying,Wang, Yanyu,Zhuang, Liping,&Qin, Shaozheng.(2021).Negative Parenting Affects Adolescent Internalizing Symptoms Through Alterations in Amygdala-Prefrontal Circuitry: A Longitudinal Twin Study.BIOLOGICAL PSYCHIATRY,89(6),560-569.
MLA Jiang, Nengzhi,et al."Negative Parenting Affects Adolescent Internalizing Symptoms Through Alterations in Amygdala-Prefrontal Circuitry: A Longitudinal Twin Study".BIOLOGICAL PSYCHIATRY 89.6(2021):560-569.
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