Institutional Repository of Key Laboratory of Mental Health, CAS
Negative Parenting Affects Adolescent Internalizing Symptoms Through Alterations in Amygdala-Prefrontal Circuitry: A Longitudinal Twin Study | |
Jiang, Nengzhi1,2,4; Xu, Jiahua3,5,6,7; Li, Xinying1,4; Wang, Yanyu2; Zhuang, Liping3,5,6,7; Qin, Shaozheng3,5,6,7 | |
第一作者 | Jiang, Nengzhi |
心理所单位排序 | 1 |
摘要 | BACKGROUND: The synergic interaction of risk genes and environmental factors has been thought to play a critical role in mediating emotion-related brain circuitry function and dysfunction in depression and anxiety disorders. Little, however, is known regarding neurodevelopmental bases underlying how maternal negative parenting affects emotion-related brain circuitry linking to adolescent internalizing symptoms and whether this neurobehavioral association is heritable during adolescence. METHODS: The effects of maternal parenting on amygdala-based emotional circuitry and internalizing symptoms were examined by using longitudinal functional magnetic resonance imaging among 100 monozygotic twins and 78 dizygotic twins from early adolescence (age 13 years) to mid-adolescence (age 16 years). The mediation effects among variables of interest and their heritability were assessed by structural equation modeling and quantitative genetic analysis, respectively. RESULTS: Exposure to maternal negative parenting was positively predictive of stronger functional connectivity of the amygdala with the ventrolateral prefrontal cortex. This neural pathway mediated the association between negative parenting and adolescent depressive symptoms and exhibited moderate heritability (21%). CONCLUSIONS: These findings highlight that maternal negative parenting in early adolescence is associated with the development of atypical amygdala-prefrontal connectivity in relation to internalizing depressive symptoms in midadolescence. Such abnormality of emotion-related brain circuitry is heritable to a moderate degree. |
2021-03-15 | |
DOI | 10.1016/j.biopsych.2020.08.002 |
发表期刊 | BIOLOGICAL PSYCHIATRY |
ISSN | 0006-3223 |
卷号 | 89期号:6页码:560-569 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China[31530031] ; National Natural Science Foundation of China[31522028] ; National Natural Science Foundation of China[81571056] ; Medical Science Foundation of Shandong Province[2017WS759] ; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning in China[CNLZD1503] |
出版者 | ELSEVIER SCIENCE INC |
WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
WOS类目 | Neurosciences ; Psychiatry |
WOS记录号 | WOS:000618784800008 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/38645 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Li, Xinying; Qin, Shaozheng |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China 2.Weifang Med Univ, Sch Psychol, Weifang, Peoples R China 3.Chinese Inst Brain Res, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 5.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China 6.Beijing Normal Univ, Beijing Key Lab Brain Imaging & Connect, Beijing, Peoples R China 7.Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing, Peoples R China |
第一作者单位 | 中国科学院心理健康重点实验室 |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Jiang, Nengzhi,Xu, Jiahua,Li, Xinying,et al. Negative Parenting Affects Adolescent Internalizing Symptoms Through Alterations in Amygdala-Prefrontal Circuitry: A Longitudinal Twin Study[J]. BIOLOGICAL PSYCHIATRY,2021,89(6):560-569. |
APA | Jiang, Nengzhi,Xu, Jiahua,Li, Xinying,Wang, Yanyu,Zhuang, Liping,&Qin, Shaozheng.(2021).Negative Parenting Affects Adolescent Internalizing Symptoms Through Alterations in Amygdala-Prefrontal Circuitry: A Longitudinal Twin Study.BIOLOGICAL PSYCHIATRY,89(6),560-569. |
MLA | Jiang, Nengzhi,et al."Negative Parenting Affects Adolescent Internalizing Symptoms Through Alterations in Amygdala-Prefrontal Circuitry: A Longitudinal Twin Study".BIOLOGICAL PSYCHIATRY 89.6(2021):560-569. |
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文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Negative Parenting A(1037KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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