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Negative Parenting Affects Adolescent Internalizing Symptoms Through Alterations in Amygdala-Prefrontal Circuitry: A Longitudinal Twin Study
Jiang, Nengzhi1,2,4; Xu, Jiahua3,5,6,7; Li, Xinying1,4; Wang, Yanyu2; Zhuang, Liping3,5,6,7; Qin, Shaozheng3,5,6,7
First AuthorJiang, Nengzhi
Contribution Rank1
Abstract

BACKGROUND: The synergic interaction of risk genes and environmental factors has been thought to play a critical role in mediating emotion-related brain circuitry function and dysfunction in depression and anxiety disorders. Little, however, is known regarding neurodevelopmental bases underlying how maternal negative parenting affects emotion-related brain circuitry linking to adolescent internalizing symptoms and whether this neurobehavioral association is heritable during adolescence. METHODS: The effects of maternal parenting on amygdala-based emotional circuitry and internalizing symptoms were examined by using longitudinal functional magnetic resonance imaging among 100 monozygotic twins and 78 dizygotic twins from early adolescence (age 13 years) to mid-adolescence (age 16 years). The mediation effects among variables of interest and their heritability were assessed by structural equation modeling and quantitative genetic analysis, respectively. RESULTS: Exposure to maternal negative parenting was positively predictive of stronger functional connectivity of the amygdala with the ventrolateral prefrontal cortex. This neural pathway mediated the association between negative parenting and adolescent depressive symptoms and exhibited moderate heritability (21%). CONCLUSIONS: These findings highlight that maternal negative parenting in early adolescence is associated with the development of atypical amygdala-prefrontal connectivity in relation to internalizing depressive symptoms in midadolescence. Such abnormality of emotion-related brain circuitry is heritable to a moderate degree.

2021-03-15
DOI10.1016/j.biopsych.2020.08.002
Source PublicationBIOLOGICAL PSYCHIATRY
ISSN0006-3223
Volume89Issue:6Pages:560-569
Subtype实证研究
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[31530031] ; National Natural Science Foundation of China[31522028] ; National Natural Science Foundation of China[81571056] ; Medical Science Foundation of Shandong Province[2017WS759] ; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning in China[CNLZD1503]
PublisherELSEVIER SCIENCE INC
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectNeurosciences ; Psychiatry
WOS IDWOS:000618784800008
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/38645
Collection中国科学院心理健康重点实验室
Corresponding AuthorLi, Xinying; Qin, Shaozheng
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
2.Weifang Med Univ, Sch Psychol, Weifang, Peoples R China
3.Chinese Inst Brain Res, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
5.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China
6.Beijing Normal Univ, Beijing Key Lab Brain Imaging & Connect, Beijing, Peoples R China
7.Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Jiang, Nengzhi,Xu, Jiahua,Li, Xinying,et al. Negative Parenting Affects Adolescent Internalizing Symptoms Through Alterations in Amygdala-Prefrontal Circuitry: A Longitudinal Twin Study[J]. BIOLOGICAL PSYCHIATRY,2021,89(6):560-569.
APA Jiang, Nengzhi,Xu, Jiahua,Li, Xinying,Wang, Yanyu,Zhuang, Liping,&Qin, Shaozheng.(2021).Negative Parenting Affects Adolescent Internalizing Symptoms Through Alterations in Amygdala-Prefrontal Circuitry: A Longitudinal Twin Study.BIOLOGICAL PSYCHIATRY,89(6),560-569.
MLA Jiang, Nengzhi,et al."Negative Parenting Affects Adolescent Internalizing Symptoms Through Alterations in Amygdala-Prefrontal Circuitry: A Longitudinal Twin Study".BIOLOGICAL PSYCHIATRY 89.6(2021):560-569.
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