Precuneus Dysfunction in Parkinson's Disease With Mild Cognitive Impairment

doi:10.3389/fnagi.2018.00427

	Precuneus Dysfunction in Parkinson's Disease With Mild Cognitive Impairment
	Jia,Xiuqin 1,2; Li,Ying 3; Li,Kuncheng 3,4; Liang,Peipeng 5; Fu,Xiaolan1,6
第一作者	Jia, Xiuqin
通讯作者邮箱	ppliang@cnu.edu.cn ; fuxl@psych.ac.cn
心理所单位排序	1
摘要	Background: Mild cognitive impairment (MCI) frequently occurs in Parkinson's disease (PD). Neurovascular changes interact with neurodegenerative processes in PD. However, the deficits of cerebral blood flow (CBF) perfusion and the associated functional connectivity (FC) in PD patients with MCI (PD-MCI) remain unclear. Purpose: This study aimed to explore the specific neurovascular perfusion alterations in PD-MCI compared to PD with normal cognition (PD-NC) and healthy controls (HCs), and to further examine the resultant whole brain FC changes in the abnormal perfusion regions. Methods: Relative CBF (rCBF) was calculated using arterial spin labeling (ASL) in 54 patients with PD (27 patients with PD-NC and 27 patients with PD-MCI) and 25 HCs matched for age and gender ratio, who also underwent the structural MRI, resting-state functional MRI (rs-fMRI) and neuropsychological examinations. The gray matter (GM) changes in PD patients were analyzed using voxel-based morphometry (VBM). The alterations in rCBF perfusion and FC among groups were then analyzed respectively. Additionally, correlations between these alterations and neuropsychological performances were further examined. Results: Compared to HC, left caudate atrophy was detected in patients with PD. In comparison to both PD-NC and HC, patients with PD-MCI specifically exhibited hypoperfusion in the parietal memory network (PMN) in the precuneus (PCu) and decreased PCu-FC in the right striatum. Moreover, PCu perfusion and PCu-FC strengths in the right striatum were positively associated with memory performance in PD-MCI. Conclusions: These findings suggest that the posterior PMN dysfunction underlies memory deficits in PD-MCI.
关键词	Parkinson's Disease With Mild Cognitive Impairment Parietal Memory Network Arterial Spin Labeling (Asl) Functional Connectivity (Fc) Precuneus
	2019-01-10
语种	英语
DOI	10.3389/fnagi.2018.00427
发表期刊	FRONTIERS IN AGING NEUROSCIENCE
ISSN	1663-4365
卷号	10 页码:9
URL	查看原文
收录类别	SCI
WOS关键词	Parietal Memory Network ; Resting-state ; Functional Connectivity ; Gray-matter ; Cortical Hypoperfusion ; Perfusion ; Mri ; Patterns ; Quantification ; Single
WOS研究方向	Geriatrics & Gerontology ; Neurosciences & Neurology
WOS类目	Geriatrics & Gerontology ; Neurosciences
WOS记录号	WOS:000455391000001
WOS分区	Q1
病症	Parkinson’ s disease
取样对象	人类
性别	男 ; 女
年龄组	中年（40岁-64岁） ; 老年（65岁以上）
被试数量	90
国家或地区	China
省份	BeiJing
测试或任务	structural MRI; resting-state functional MRI (rs-fMRI); neuropsychological examinations; UPDRS part III
因变量指标	voxel-based morphometry(VBM); functional connectivity (FC)
实验仪器	Siemens Tim Trio 3T MRI system; Q2TIPS II;
统计软件	SPM12
统计方法	Kolmogorov-Smirnov (KS) test; one-way ANOVA; Kruskal-Wallis testing; one-way analysis of covariance (ANCOVA); Correlation Analysis
引用统计	被引频次：42[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/38665
专题	脑与认知科学国家重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China; 2.Capital Med Univ, Beijing Chaoyang Hosp, Dept Radiol, Beijing, Peoples R China; 3.Capital Med Univ, Anzhen Hosp, Dept Radiol, Beijing, Peoples R China; 4.Beijing Key Lab MRI & Brain Informat, Beijing, Peoples R China; 5.Capital Normal Univ, Sch Psychol, Beijing, Peoples R China; 6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
第一作者单位	脑与认知科学国家重点实验室
推荐引用方式 GB/T 7714	Jia,Xiuqin,Li,Ying,Li,Kuncheng,et al. Precuneus Dysfunction in Parkinson's Disease With Mild Cognitive Impairment[J]. FRONTIERS IN AGING NEUROSCIENCE,2019,10:9.
APA	Jia,Xiuqin,Li,Ying,Li,Kuncheng,Liang,Peipeng,&Fu,Xiaolan.(2019).Precuneus Dysfunction in Parkinson's Disease With Mild Cognitive Impairment.FRONTIERS IN AGING NEUROSCIENCE,10,9.
MLA	Jia,Xiuqin,et al."Precuneus Dysfunction in Parkinson's Disease With Mild Cognitive Impairment".FRONTIERS IN AGING NEUROSCIENCE 10(2019):9.