Institutional Repository of Key Laboratory of Behavioral Science, CAS
Disrupted hemispheric connectivity specialization in patients with major depressive disorder: Evidence from the REST-meta-MDD Project | |
Ding, Yu-Dan1,2; Yang, Ru3; Yan, Chao-Gan4,5,6,7,8; Chen, Xiao4,5; Bai, Tong-Jian9; Bo, Qi-Jing10; Chen, Guan-Mao11; Chen, Ning-Xuan4,5; Chen, Tao-Lin16,17; Chen, Wei12; Cheng, Chang1,2; Cheng, Yu-Qi13; Cui, Xi-Long1,2; Duan, Jia14; Fang, Yi-Ru15; Gong, Qi-Yong16,17; Hou, Zheng-Hua18; Hu, Lan19; Kuang, Li20; Li, Feng10; Li, Tao20; Liu, Yan-Song21; Liu, Zhe-Ning22; Long, Yi-Cheng23; Luo, Qing-Hua19; Meng, Hua-Qing19; Peng, Dai-Hui15; Qiu, Hai-Tang19; Qiu, Jiang23; Shen, Yue-Di24; Shi, Yu-Shu25; Tang, Yanqing10; Wang, Chuan-Yue10; Wang, Fei14; Wang, Kai9; Wang, Li26,27; Wang, Xiang1,2; Wang, Ying11; Wu, Xiao-Ping28; Wu, Xin-Ran23; Xie, Chun-Ming29; Xie, Guang-Rong1,2; Xie, Hai-Yan30; Xie, Peng31,32,33; Xu, Xiu-Feng13; Yang, Hong25; Yang, Jian34; Yao, Jia-Shu13; Yao, Shu-Qiao1,2; Yin, Ying-Ying18; Yuan, Yong-Gui18; Zhang, Ai-Xia34; Zhang, Hong28; Zhang, Ke-Rang35; Zhang, Lei4,5; Zhang, Zhi-Jun29; Zhou, Ru-Bai15; Zhou, Yi-Ting20; Zhu, Jun-Juan15; Zou, Chao-Jie13; Si, Tian-Mei26,27; Zang, Yu-Feng36,37; Zhao, Jing-Ping1,2; Guo, Wen-Bin1,2 | |
第一作者 | Ding, Yu-Dan |
通讯作者邮箱 | wen-bin guo |
心理所单位排序 | 4 |
摘要 | Background: : Functional specialization is a feature of human brain for understanding the pathophysiology of major depressive disorder (MDD). The degree of human specialization refers to within and cross hemispheric interactions. However, most previous studies only focused on interhemispheric connectivity in MDD, and the results varied across studies. Hence, brain functional connectivity asymmetry in MDD should be further studied. Methods: : Resting-state fMRI data of 753 patients with MDD and 451 healthy controls were provided by RESTmeta-MDD Project. Twenty-five project contributors preprocessed their data locally with the Data Processing Assistant State fMRI software and shared final indices. The parameter of asymmetry (PAS), a novel voxel-based whole-brain quantitative measure that reflects interand intrahemispheric asymmetry, was reported. We also examined the effects of age, sex and clinical variables (including symptom severity, illness duration and three depressive phenotypes). Results: : Compared with healthy controls, patients with MDD showed increased PAS scores (decreased hemispheric specialization) in most of the areas of default mode network, control network, attention network and some regions in the cerebellum and visual cortex. Demographic characteristics and clinical variables have significant effects on these abnormalities. Limitations: : Although a large sample size could improve statistical power, future independent efforts are needed to confirm our results. Conclusions: : Our results highlight the idea that many brain networks contribute to broad clinical pathophysiology of MDD, and indicate that a lateralized, efficient and economical brain information processing system is disrupted in MDD. These findings may help comprehensively clarify the pathophysiology of MDD in a new hemispheric specialization perspective. |
关键词 | Major depressive disorder hemispheric asymmetry parameter of asymmetry fMRI Abbreviations ACC, Anterior cingulate gyrus DLPFC, Dorsolateral prefrontal cortex DMN, Default mode network DPARSF, Data Processing Assistant for Resting-State fMRI DSM, Diagnosic and Statistical Manual of Mental Disorders EEG, Electroencephalographic FC, Functional connectivity FDR, False discovery rate FEDN, First-episode, drug-naive FEF, Frontal eye fields fMRI, Functional magnetic resonance imaging HAMD, Hamilton Depression Rating Scale HC, Healthy control IFG, Inferior frontal gyrus IPL, Inferior parietal lobule IPS/SPL, Intraparietal sulcus/superior parietal lobule LMM, Linear mixed model MDD, Major depressive disorder MFG, Middle frontal gyrus MTG, Middle temporal gyrus PAS, Parameter of asymmetry PCC, Posterior cingulate cortex PET, Positron emission tomography ROIs, Regions of interest rs-fMRI, Resting-state fMRI rTMS, repetitive transcranial magnetic stimulation STS, Superior temporal sulcus VMHC, Voxel-mirrored homotopic connectivity |
2021-04-01 | |
语种 | 英语 |
DOI | 10.1016/j.jad.2021.02.030 |
发表期刊 | JOURNAL OF AFFECTIVE DISORDERS |
ISSN | 0165-0327 |
卷号 | 284页码:217-228 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | National Key R&D Program of China[2016YFC1307100] ; National Key R&D Program of China[2016YFC1306900] ; National Natural Science Foundation of China[81771447] ; National Natural Science Foundation of China[81630033] ; Natural Science Foundation of Hunan[2020JJ4784] |
出版者 | ELSEVIER |
WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
WOS类目 | Clinical Neurology ; Psychiatry |
WOS记录号 | WOS:000623621400026 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/38687 |
专题 | 中国科学院行为科学重点实验室 |
通讯作者 | Guo, Wen-Bin |
作者单位 | 1.Cent South Univ, Natl Clin Res Ctr Mental Disorders, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China 2.Cent South Univ, Dept Psychiat, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China 3.Cent South Univ, Dept Radiol, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China 4.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 6.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Beijing, Peoples R China 7.Chinese Acad Sci, Res Ctr Lifespan Dev Mind & Brain Climb, Inst Psychol, Beijing, Peoples R China 8.Chinese Acad Sci, Int Big Data Ctr Depress Res, Inst Psychol, Beijing, Peoples R China 9.Anhui Med Univ, Hefei, Anhui, Peoples R China 10.Capital Med Univ, Beijing Anding Hosp, Beijing 100054, Peoples R China 11.Jinan Univ, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China 12.Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Hangzhou 310016, Zhejiang, Peoples R China 13.Kunming Med Univ, Affiliated Hosp 1, Kunming 650221, Yunnan, Peoples R China 14.China Med Univ, Affiliated Hosp 1, Dept Psychiat, Shenyang, Liaoning, Peoples R China 15.Shanghai Jiao Tong Univ, Dept Psychiat, Sch Med, Shanghai 200240, Peoples R China 16.Sichuan Univ, Huaxi MR Res Ctr, Dept Radiol, West China Hosp, Chengdu 610041, Sichuan, Peoples R China 17.Sichuan Univ, Chinese Acad Med Sci, West China Hosp, Psychoradiol Res Unit, Chengdu 610041, Sichuan, Peoples R China 18.Southeast Univ, Zhongda Hosp, Sch Med, Dept Psychosomat & Psychiat, Nanjing 210096, Jiangsu, Peoples R China 19.Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing, Peoples R China 20.Sichuan Univ, West China Hosp, Mental Hlth Ctr, Chengdu, Sichuan, Peoples R China 21.Soochow Univ, Suzhou Psychiat Hosp, Dept Clin Psychol, Affiliated Guangji Hosp, Suzhou, Jiangsu, Peoples R China 22.Cent South Univ, Inst Mental Hlth, Xiangya Hosp 2, Changsha 410008, Hunan, Peoples R China 23.Southwest Univ, Fac Psychol, Chongqing 400716, Peoples R China 24.Hangzhou Normal Univ, Affiliated Hosp, Dept Diagnost, Med Sch, Hangzhou 311121, Zhejiang, Peoples R China 25.Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Radiol, Hangzhou 310058, Zhejiang, Peoples R China 26.Peking Univ, Natl Clin Res Ctr Mental Disorders, Hosp 6, Beijing 100191, Peoples R China 27.Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing 100191, Peoples R China 28.Xian Cent Hosp, Xian, Shaanxi, Peoples R China 29.Southeast Univ, Dept Neurol, Affiliated ZhongDa Hosp, Nanjing 210009, Jiangsu, Peoples R China 30.Zhejiang Univ, Affiliated Hosp 4, Coll Med, Dept Psychiat, Hangzhou 310058, Zhejiang, Peoples R China 31.Chongqing Med Univ, Inst Neurosci, Chongqing 400016, Peoples R China 32.Chongqing Key Lab Neurobiol, Chongqing 400016, Peoples R China 33.Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China 34.Xi An Jiao Tong Univ, Affiliated Hosp 1, Xian 710061, Shaanxi, Peoples R China 35.Shanxi Med Univ, Hosp 1, Taiyuan 030006, Shanxi, Peoples R China 36.Hangzhou Normal Univ, Ctr Cognit & Brain Disorders, Inst Psychol Sci, Hangzhou 311121, Zhejiang, Peoples R China 37.Zhejiang Key Lab Res Assessment Cognit Impairment, Hangzhou 311121, Zhejiang, Peoples R China |
推荐引用方式 GB/T 7714 | Ding, Yu-Dan,Yang, Ru,Yan, Chao-Gan,et al. Disrupted hemispheric connectivity specialization in patients with major depressive disorder: Evidence from the REST-meta-MDD Project[J]. JOURNAL OF AFFECTIVE DISORDERS,2021,284:217-228. |
APA | Ding, Yu-Dan.,Yang, Ru.,Yan, Chao-Gan.,Chen, Xiao.,Bai, Tong-Jian.,...&Guo, Wen-Bin.(2021).Disrupted hemispheric connectivity specialization in patients with major depressive disorder: Evidence from the REST-meta-MDD Project.JOURNAL OF AFFECTIVE DISORDERS,284,217-228. |
MLA | Ding, Yu-Dan,et al."Disrupted hemispheric connectivity specialization in patients with major depressive disorder: Evidence from the REST-meta-MDD Project".JOURNAL OF AFFECTIVE DISORDERS 284(2021):217-228. |
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