PSYCH OpenIR  > 中国科学院行为科学重点实验室
Disrupted hemispheric connectivity specialization in patients with major depressive disorder: Evidence from the REST-meta-MDD Project
Ding, Yu-Dan1,2; Yang, Ru3; Yan, Chao-Gan4,5,6,7,8; Chen, Xiao4,5; Bai, Tong-Jian9; Bo, Qi-Jing10; Chen, Guan-Mao11; Chen, Ning-Xuan4,5; Chen, Tao-Lin16,17; Chen, Wei12; Cheng, Chang1,2; Cheng, Yu-Qi13; Cui, Xi-Long1,2; Duan, Jia14; Fang, Yi-Ru15; Gong, Qi-Yong16,17; Hou, Zheng-Hua18; Hu, Lan19; Kuang, Li20; Li, Feng10; Li, Tao20; Liu, Yan-Song21; Liu, Zhe-Ning22; Long, Yi-Cheng23; Luo, Qing-Hua19; Meng, Hua-Qing19; Peng, Dai-Hui15; Qiu, Hai-Tang19; Qiu, Jiang23; Shen, Yue-Di24; Shi, Yu-Shu25; Tang, Yanqing10; Wang, Chuan-Yue10; Wang, Fei14; Wang, Kai9; Wang, Li26,27; Wang, Xiang1,2; Wang, Ying11; Wu, Xiao-Ping28; Wu, Xin-Ran23; Xie, Chun-Ming29; Xie, Guang-Rong1,2; Xie, Hai-Yan30; Xie, Peng31,32,33; Xu, Xiu-Feng13; Yang, Hong25; Yang, Jian34; Yao, Jia-Shu13; Yao, Shu-Qiao1,2; Yin, Ying-Ying18; Yuan, Yong-Gui18; Zhang, Ai-Xia34; Zhang, Hong28; Zhang, Ke-Rang35; Zhang, Lei4,5; Zhang, Zhi-Jun29; Zhou, Ru-Bai15; Zhou, Yi-Ting20; Zhu, Jun-Juan15; Zou, Chao-Jie13; Si, Tian-Mei26,27; Zang, Yu-Feng36,37; Zhao, Jing-Ping1,2; Guo, Wen-Bin1,2
First AuthorDing, Yu-Dan
Correspondent Emailwen-bin guo
Contribution Rank4
Abstract

Background: : Functional specialization is a feature of human brain for understanding the pathophysiology of major depressive disorder (MDD). The degree of human specialization refers to within and cross hemispheric interactions. However, most previous studies only focused on interhemispheric connectivity in MDD, and the results varied across studies. Hence, brain functional connectivity asymmetry in MDD should be further studied. Methods: : Resting-state fMRI data of 753 patients with MDD and 451 healthy controls were provided by RESTmeta-MDD Project. Twenty-five project contributors preprocessed their data locally with the Data Processing Assistant State fMRI software and shared final indices. The parameter of asymmetry (PAS), a novel voxel-based whole-brain quantitative measure that reflects interand intrahemispheric asymmetry, was reported. We also examined the effects of age, sex and clinical variables (including symptom severity, illness duration and three depressive phenotypes). Results: : Compared with healthy controls, patients with MDD showed increased PAS scores (decreased hemispheric specialization) in most of the areas of default mode network, control network, attention network and some regions in the cerebellum and visual cortex. Demographic characteristics and clinical variables have significant effects on these abnormalities. Limitations: : Although a large sample size could improve statistical power, future independent efforts are needed to confirm our results. Conclusions: : Our results highlight the idea that many brain networks contribute to broad clinical pathophysiology of MDD, and indicate that a lateralized, efficient and economical brain information processing system is disrupted in MDD. These findings may help comprehensively clarify the pathophysiology of MDD in a new hemispheric specialization perspective.

KeywordMajor depressive disorder hemispheric asymmetry parameter of asymmetry fMRI Abbreviations ACC, Anterior cingulate gyrus DLPFC, Dorsolateral prefrontal cortex DMN, Default mode network DPARSF, Data Processing Assistant for Resting-State fMRI DSM, Diagnosic and Statistical Manual of Mental Disorders EEG, Electroencephalographic FC, Functional connectivity FDR, False discovery rate FEDN, First-episode, drug-naive FEF, Frontal eye fields fMRI, Functional magnetic resonance imaging HAMD, Hamilton Depression Rating Scale HC, Healthy control IFG, Inferior frontal gyrus IPL, Inferior parietal lobule IPS/SPL, Intraparietal sulcus/superior parietal lobule LMM, Linear mixed model MDD, Major depressive disorder MFG, Middle frontal gyrus MTG, Middle temporal gyrus PAS, Parameter of asymmetry PCC, Posterior cingulate cortex PET, Positron emission tomography ROIs, Regions of interest rs-fMRI, Resting-state fMRI rTMS, repetitive transcranial magnetic stimulation STS, Superior temporal sulcus VMHC, Voxel-mirrored homotopic connectivity
2021-04-01
Language英语
DOI10.1016/j.jad.2021.02.030
Source PublicationJOURNAL OF AFFECTIVE DISORDERS
ISSN0165-0327
Volume284Pages:217-228
Subtype实证研究
Indexed BySCI
Funding ProjectNational Key R&D Program of China[2016YFC1307100] ; National Key R&D Program of China[2016YFC1306900] ; National Natural Science Foundation of China[81771447] ; National Natural Science Foundation of China[81630033] ; Natural Science Foundation of Hunan[2020JJ4784]
PublisherELSEVIER
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectClinical Neurology ; Psychiatry
WOS IDWOS:000623621400026
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/38687
Collection中国科学院行为科学重点实验室
Corresponding AuthorGuo, Wen-Bin
Affiliation1.Cent South Univ, Natl Clin Res Ctr Mental Disorders, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China
2.Cent South Univ, Dept Psychiat, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China
3.Cent South Univ, Dept Radiol, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China
4.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
6.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Beijing, Peoples R China
7.Chinese Acad Sci, Res Ctr Lifespan Dev Mind & Brain Climb, Inst Psychol, Beijing, Peoples R China
8.Chinese Acad Sci, Int Big Data Ctr Depress Res, Inst Psychol, Beijing, Peoples R China
9.Anhui Med Univ, Hefei, Anhui, Peoples R China
10.Capital Med Univ, Beijing Anding Hosp, Beijing 100054, Peoples R China
11.Jinan Univ, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China
12.Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Hangzhou 310016, Zhejiang, Peoples R China
13.Kunming Med Univ, Affiliated Hosp 1, Kunming 650221, Yunnan, Peoples R China
14.China Med Univ, Affiliated Hosp 1, Dept Psychiat, Shenyang, Liaoning, Peoples R China
15.Shanghai Jiao Tong Univ, Dept Psychiat, Sch Med, Shanghai 200240, Peoples R China
16.Sichuan Univ, Huaxi MR Res Ctr, Dept Radiol, West China Hosp, Chengdu 610041, Sichuan, Peoples R China
17.Sichuan Univ, Chinese Acad Med Sci, West China Hosp, Psychoradiol Res Unit, Chengdu 610041, Sichuan, Peoples R China
18.Southeast Univ, Zhongda Hosp, Sch Med, Dept Psychosomat & Psychiat, Nanjing 210096, Jiangsu, Peoples R China
19.Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing, Peoples R China
20.Sichuan Univ, West China Hosp, Mental Hlth Ctr, Chengdu, Sichuan, Peoples R China
21.Soochow Univ, Suzhou Psychiat Hosp, Dept Clin Psychol, Affiliated Guangji Hosp, Suzhou, Jiangsu, Peoples R China
22.Cent South Univ, Inst Mental Hlth, Xiangya Hosp 2, Changsha 410008, Hunan, Peoples R China
23.Southwest Univ, Fac Psychol, Chongqing 400716, Peoples R China
24.Hangzhou Normal Univ, Affiliated Hosp, Dept Diagnost, Med Sch, Hangzhou 311121, Zhejiang, Peoples R China
25.Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Radiol, Hangzhou 310058, Zhejiang, Peoples R China
26.Peking Univ, Natl Clin Res Ctr Mental Disorders, Hosp 6, Beijing 100191, Peoples R China
27.Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing 100191, Peoples R China
28.Xian Cent Hosp, Xian, Shaanxi, Peoples R China
29.Southeast Univ, Dept Neurol, Affiliated ZhongDa Hosp, Nanjing 210009, Jiangsu, Peoples R China
30.Zhejiang Univ, Affiliated Hosp 4, Coll Med, Dept Psychiat, Hangzhou 310058, Zhejiang, Peoples R China
31.Chongqing Med Univ, Inst Neurosci, Chongqing 400016, Peoples R China
32.Chongqing Key Lab Neurobiol, Chongqing 400016, Peoples R China
33.Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China
34.Xi An Jiao Tong Univ, Affiliated Hosp 1, Xian 710061, Shaanxi, Peoples R China
35.Shanxi Med Univ, Hosp 1, Taiyuan 030006, Shanxi, Peoples R China
36.Hangzhou Normal Univ, Ctr Cognit & Brain Disorders, Inst Psychol Sci, Hangzhou 311121, Zhejiang, Peoples R China
37.Zhejiang Key Lab Res Assessment Cognit Impairment, Hangzhou 311121, Zhejiang, Peoples R China
Recommended Citation
GB/T 7714
Ding, Yu-Dan,Yang, Ru,Yan, Chao-Gan,et al. Disrupted hemispheric connectivity specialization in patients with major depressive disorder: Evidence from the REST-meta-MDD Project[J]. JOURNAL OF AFFECTIVE DISORDERS,2021,284:217-228.
APA Ding, Yu-Dan.,Yang, Ru.,Yan, Chao-Gan.,Chen, Xiao.,Bai, Tong-Jian.,...&Guo, Wen-Bin.(2021).Disrupted hemispheric connectivity specialization in patients with major depressive disorder: Evidence from the REST-meta-MDD Project.JOURNAL OF AFFECTIVE DISORDERS,284,217-228.
MLA Ding, Yu-Dan,et al."Disrupted hemispheric connectivity specialization in patients with major depressive disorder: Evidence from the REST-meta-MDD Project".JOURNAL OF AFFECTIVE DISORDERS 284(2021):217-228.
Files in This Item:
File Name/Size DocType Version Access License
Disrupted hemispheri(2897KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Ding, Yu-Dan]'s Articles
[Yang, Ru]'s Articles
[Yan, Chao-Gan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Ding, Yu-Dan]'s Articles
[Yang, Ru]'s Articles
[Yan, Chao-Gan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Ding, Yu-Dan]'s Articles
[Yang, Ru]'s Articles
[Yan, Chao-Gan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.