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Formalin-induced pain prolongs sub- to supra-second time estimation in rats
Liu, Xinhe1,2; Wang, Ning1,2; Wang, Jinyan1,2; Luo, Fei1,2
First AuthorLiu, Xinhe
Correspondent Emailwangn@psych.ac.cn (ning wang)
Contribution Rank1
Abstract

Background. Temporal estimation can be influenced by pain, which is a complex psychological and physiological phenomenon. However, the time range in which perception is most sensitive to pain remains unclear. Methods. In the present study, we explored the effects of acute inflammatory pain on time perception in the sub- to supra-second (0.6-2.4-s) and supra-second (2-8-s) ranges in rats. Plantar formalin injection was used to induce acute inflammatory pain, and a temporal bisection task was used to measure time perception. Task test sessions were held for five consecutive days (one per day): the day before injection (baseline), immediately after injection, and the three post-injection days. The point of subjective equality (PSE, which reflects the subjective duration) and Weber fraction (which reflects temporal sensitivity) were calculated and analysed. Results. In the 0.6-2.4-s range, the PSE was significantly lower, indicating prolonged subjective duration, in the formalin group relative to the saline group (p = 0.049) immediately after injection. Formalin-induced pain also tended to lengthened time perception in the 0.6-2.4-s range on post-injection days 2 (p = 0.06) and 3 (p = 0.054). In the 2-8-s range, formalin injection did not affect the PSE or Weber fraction. Conclusions. The enhanced effect of pain on temporal perception in the sub- to supra-second range is observed in this study and this effect is attenuated with the prolongation of estimated time, even in rats.

KeywordTime perception Formalin-induced pain Temporal bisection task Temporal range
2021-03-02
Language英语
DOI10.7717/peerj.11002
Source PublicationPEERJ
ISSN2167-8359
Volume9Pages:21
Subtype实证研究
Indexed BySCI
Funding ProjectNNSF (National Natural Science Foundation of China)[31671140] ; NNSF (National Natural Science Foundation of China)[31271092] ; NNSF (National Natural Science Foundation of China)[31970926] ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH 2014G01] ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2016K02] ; initiation fund of the CAS/SAFEA International Partnership Program for Creative Research Teams[Y2CX131003]
PublisherPEERJ INC
WOS KeywordTEMPORAL DISCRIMINATION ; INFLAMMATORY PAIN ; PERCEPTION ; ATTENTION ; FEAR ; MODULATION ; MODEL ; MECHANISMS ; DURATION ; BEHAVIOR
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000624294300013
WoS QuartileQ2
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/38690
Collection中国科学院心理健康重点实验室
Corresponding AuthorWang, Ning
Affiliation1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Liu, Xinhe,Wang, Ning,Wang, Jinyan,et al. Formalin-induced pain prolongs sub- to supra-second time estimation in rats[J]. PEERJ,2021,9:21.
APA Liu, Xinhe,Wang, Ning,Wang, Jinyan,&Luo, Fei.(2021).Formalin-induced pain prolongs sub- to supra-second time estimation in rats.PEERJ,9,21.
MLA Liu, Xinhe,et al."Formalin-induced pain prolongs sub- to supra-second time estimation in rats".PEERJ 9(2021):21.
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