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BDNF affects the mediating effect of negative symptoms on the relationship between age of onset and cognition in patients with chronic schizophrenia
Xu, Hang1; Wang, Jiesi1; Zhou, Yongjie4; Chen, Dachun3; Xiu, Meihong3; Wang, Li1,2; Zhang, Xiangyang1,2
First AuthorXu, Hang
Correspondent Emailzhangxy@psych.ac.cn (x. zhang)
Contribution Rank1
Abstract

The age of onset of schizophrenia is related to variability in cognitive function and clinical characters, and negative symptoms and cognitive function share similar features that could be closely connected. Alterations in brain-derived neurotrophic factor (BDNF) expression and the Val66Met (rs6562) polymorphism are involved in the pathogenesis of the disease, but few studies have explored its influence on the associations of age of onset, cognitive function and clinical symptoms in schizophrenia. The clinical symptoms of a total of 573 patients with chronic schizophrenia were assessed by using the Positive and Negative Syndrome Scale (PANSS). Cognitive performance was assessed by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). The serum BDNF level and Val66Met polymorphism were measured after the assessment. Our results showed the following: (1) patients with an earlier age of onset exhibited more negative symptoms and cognitive deficits, as well as lower levels of serum BDNF; (2) negative symptoms and cognitive function showed negative and positive correlations with age of onset, respectively, and worse cognitive function was associated with a high level of negative symptoms and a low level of serum BDNF; and (3) the moderated mediation analyses indicated that negative symptoms partially mediated the relationship between age of onset and cognitive deficits, which was moderated by serum BDNF. The mediating effect of negative symptoms exhibited a Met allele dose-dependent tendency. These results indicate that age of onset, cognitive function, and clinical symptoms of schizophrenia exhibit different relationships under different serum BDNF levels and BDNF Val66met polymorphisms.

KeywordAge of onset Negative symptoms Cognitive function BDNF Schizophrenia
2021-03-01
Language英语
DOI10.1016/j.psyneuen.2020.105121
Source PublicationPSYCHONEUROENDOCRINOLOGY
ISSN0306-4530
Volume125Pages:7
Subtype实证研究
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[81371477] ; Special Research Assistant program[E0ZZ0210] ; China Postdoctoral Science Foundation[E0BH0110] ; Key Laboratory Of Mental Health, Institute of Psychology, Chinese Academy of Sciences
PublisherPERGAMON-ELSEVIER SCIENCE LTD
WOS Research AreaEndocrinology & Metabolism ; Neurosciences & Neurology ; Psychiatry
WOS SubjectEndocrinology & Metabolism ; Neurosciences ; Psychiatry
WOS IDWOS:000621359600006
QuartileQ1
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/38720
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhang, Xiangyang
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Peking Univ, Beijing HuiLongGuan Hosp, Beijing, Peoples R China
4.Shenzhen Kangning Hosp, Dept Psychiat Rehabil, Shenzhen, Guangdong, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Xu, Hang,Wang, Jiesi,Zhou, Yongjie,et al. BDNF affects the mediating effect of negative symptoms on the relationship between age of onset and cognition in patients with chronic schizophrenia[J]. PSYCHONEUROENDOCRINOLOGY,2021,125:7.
APA Xu, Hang.,Wang, Jiesi.,Zhou, Yongjie.,Chen, Dachun.,Xiu, Meihong.,...&Zhang, Xiangyang.(2021).BDNF affects the mediating effect of negative symptoms on the relationship between age of onset and cognition in patients with chronic schizophrenia.PSYCHONEUROENDOCRINOLOGY,125,7.
MLA Xu, Hang,et al."BDNF affects the mediating effect of negative symptoms on the relationship between age of onset and cognition in patients with chronic schizophrenia".PSYCHONEUROENDOCRINOLOGY 125(2021):7.
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