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Associations of Vascular Risk Factors, APOE and TOMM40 Polymorphisms With Cognitive Function in Dementia-Free Chinese Older Adults: A Community-Based Study
Gui, Wenjun1,2; Qiu, Chengxuan3,4,5,6; Shao, Qi1,2; Li, Juan1,2
First AuthorGui, Wenjun
Correspondent Emaillijuan@psych.ac.cn (juan li )
Contribution Rank1
Abstract

Objective: The associations of vascular risk factors (VRFs), apolipoprotein E (APOE), and translocase of outer mitochondrial membrane 40 (TOMM40) with cognitive function have been investigated mostly in western societies. In the present study, we sought to examine the associations of VRFs [i.e., current smoking, current drinking, physical inactivity, obesity, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), diabetes, and hypertension] and variants located in APOE (epsilon 2/3/4) and TOMM40 (rs2075650) with global cognitive function in Chinese older adults, with a focus on their potential interactions. Methods: This is a cross-sectional study that included 422 permanent residents (mean age 69.2 years, 54.3% female) living in Beijing, who were free of dementia. Data were collected through interviews, clinical examinations, and laboratory tests. The two genetic polymorphisms were genotyped, and participants were dichotomized as carriers vs. non-carriers of APOE epsilon 4 or TOMM40 G. Global cognitive function was assessed with the Mini-Mental State Examination (MMSE). Data were analyzed with multivariable linear regression models. Results: Physical inactivity and diabetes were independently associated with a lower MMSE score (all p < 0.05). When four putative VRFs (i.e., current smoking, physical inactivity, high LDL-C, and diabetes) were aggregated, an increasing number of having these factors was associated with a decreasing MMSE score in a dose-response manner (p = 0.001). TOMM40 polymorphisms, independent of the APOE epsilon 4 allele, interacted with aggregated VRFs to influence cognitive performance, such that having one or more of these VRFs was particularly detrimental to the cognition of TOMM40 carriers. Further analyses revealed interactions of the TOMM40 polymorphism with (i) physical inactivity and (ii) diabetes, such that having either physical inactivity or diabetes in combination with carrying a TOMM40 G allele, compared to having neither, was significantly associated with a markedly lower MMSE score (all p < 0.05). Conclusion: This study provides some evidence supporting the association of vascular risk factors with poor cognitive performance among dementia-free Chinese older adults and further revealed their interactions with the TOMM40 polymorphism. The results underscore the vulnerability of global cognitive function to VRFs, which could be reinforced by carrying the TOMM40 rs2075650 G allele. These findings have potential implications for developing tailored intervention programs to maintain cognitive function.

Keywordaging vascular risk factors APOE TOMM40 cognitive function population-based study
2021-03-15
Language英语
DOI10.3389/fpsyt.2021.617773
Source PublicationFRONTIERS IN PSYCHIATRY
ISSN1664-0640
Volume12Pages:10
Subtype实证研究
Indexed BySCI
Funding ProjectNational Key Research and Development Program of China[2018YFC2000300] ; National Key Research and Development Program of China[2018YFC2001701] ; National Key Research and Development Program of China[2016YFC1305900] ; National Key Research and Development Program of China[2017YFB1401203] ; National Key Research and Development Program of China[2020YFC2003000] ; National Natural Science Foundation of China[32071079] ; National Natural Science Foundation of China[31861133011] ; National Natural Science Foundation of China[31671157] ; National Natural Science Foundation of China[31711530157] ; Beijing Municipal Science & Technology Commission[Z171100008217006] ; Beijing Municipal Science & Technology Commission[Z171100000117006] ; Swedish Research Council[2017-00740] ; Swedish Research Council[2017-05819] ; Swedish Research Council[2020-01574] ; Swedish Foundation for International Cooperation in Research and Higher Education (STINT)[CH2019-8320] ; Taishan Scholar Program of Shandong Province, China
PublisherFRONTIERS MEDIA SA
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000634099600001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/38767
Collection中国科学院心理健康重点实验室
Corresponding AuthorLi, Juan
Affiliation1.Chinese Acad Sci, Ctr Aging Psychol, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Shandong Univ, Dept Neurol, Shandong Prov Hosp, Jinan, Peoples R China
4.Karolinska Inst, Aging Res Ctr, Stockholm, Sweden
5.Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden
6.Stockholm Univ, Stockholm, Sweden
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Gui, Wenjun,Qiu, Chengxuan,Shao, Qi,et al. Associations of Vascular Risk Factors, APOE and TOMM40 Polymorphisms With Cognitive Function in Dementia-Free Chinese Older Adults: A Community-Based Study[J]. FRONTIERS IN PSYCHIATRY,2021,12:10.
APA Gui, Wenjun,Qiu, Chengxuan,Shao, Qi,&Li, Juan.(2021).Associations of Vascular Risk Factors, APOE and TOMM40 Polymorphisms With Cognitive Function in Dementia-Free Chinese Older Adults: A Community-Based Study.FRONTIERS IN PSYCHIATRY,12,10.
MLA Gui, Wenjun,et al."Associations of Vascular Risk Factors, APOE and TOMM40 Polymorphisms With Cognitive Function in Dementia-Free Chinese Older Adults: A Community-Based Study".FRONTIERS IN PSYCHIATRY 12(2021):10.
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