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The interactive effect of genetic polymorphisms of IL-10 and COMT on cognitive function in schizophrenia
Wang, Jiesi1,2; Xu, Hang1,2; Wang, Dongmei1,2; Wei, Gaoxia1,2; Zhou, Huixia1,2; Wang, Li1,2; Zhou, Yongjie3,4; Zhang, Xiangyang1,2
First AuthorWang, Jiesi
Correspondent Emailzhangxy@psych.ac.cn (x. zhang)
Contribution Rank1
Abstract

Dopaminergic and inflammatory systems have been proven to play an important role in the cognitive deficits of schizophrenia. Although increasing evidence indicates two systems have strong interaction, the relevant research on this interaction is still limited. Catechol-o-methyltransferase (COMT) and Interleukin-10 (IL-10) play critical functions in dopaminergic and inflammatory systems respectively, and their genetic polymorphisms are both associated with cognitive function. However, the interactive effect of their genetic polymorphisms has not been investigated. In this study, COMT Val158Met (rs4680) and IL-10 -592A/C (rs1800872) polymorphisms were measured in patients with chronic schizophrenia (n = 244) and healthy controls (n = 396), and their cognitive functions were assessed using the ?Repeatable Battery for the Assessment of Neuropsychological Status? (RBANS). We found that IL-10 alone had no effect on cognitive function, while COMT affected language ability and interacted with the schizophrenia (case vs control) or sex in multiple RBANS indexes. Additionally, we found there was a significant interactive effect between IL-10 and COMT polymorphisms on multiple cognitive indexes of RBANS. In detail, the analysis showed that the IL-10 polymorphism had opposite effects on cognitive function in different COMT genotype carriers; meanwhile, the polymorphism of COMT only had a significant effect on cognitive function in IL-10 C carriers. And this interaction was more significant in schizophrenia than in controls. Our study discovered for the first time, there is an interactive effect between IL-10 and COMT genetic polymorphisms on cognitive function, which is valuable for further investigations and drug administrations associated with both systems.

KeywordSchizophrenia Cognitive function Genetic polymorphism Interaction IL-10 COMT
2021-04-01
DOI10.1016/j.jpsychires.2020.10.021
Source PublicationJOURNAL OF PSYCHIATRIC RESEARCH
ISSN0022-3956
Volume136Pages:501-507
Subtype实证研究
Indexed BySCI ; SSCI
PublisherPERGAMON-ELSEVIER SCIENCE LTD
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000634106600021
WoS QuartileQ2
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/38831
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhang, Xiangyang
Affiliation1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.China Univ Geosci, Res Ctr Psychol & Hlth Sci, Wuhan, Peoples R China
4.Huazhong Univ Sci & Technol, Affiliated Wuhan Mental Hlth Ctr, Tongji Med Coll, Wuhan, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Wang, Jiesi,Xu, Hang,Wang, Dongmei,et al. The interactive effect of genetic polymorphisms of IL-10 and COMT on cognitive function in schizophrenia[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2021,136:501-507.
APA Wang, Jiesi.,Xu, Hang.,Wang, Dongmei.,Wei, Gaoxia.,Zhou, Huixia.,...&Zhang, Xiangyang.(2021).The interactive effect of genetic polymorphisms of IL-10 and COMT on cognitive function in schizophrenia.JOURNAL OF PSYCHIATRIC RESEARCH,136,501-507.
MLA Wang, Jiesi,et al."The interactive effect of genetic polymorphisms of IL-10 and COMT on cognitive function in schizophrenia".JOURNAL OF PSYCHIATRIC RESEARCH 136(2021):501-507.
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