PSYCH OpenIR  > 中国科学院心理健康重点实验室
Contributions of prelimbic cortex, dorsal and ventral hippocampus, and basolateral amygdala to fear return induced by elevated platform stress in rats
Xing, Xiaoli1,2; Fu, Juan1,3; Wang, Hongbo2; Zheng, Xigeng1,4
First AuthorXing, Xiaoli
Correspondent Emailzhengxg@psych.ac.cn (x. zheng)
Contribution Rank1
Abstract

Fear relapse is a major challenge in the treatment of stress-related mental disorders. Most investigations have focused on fear return induced by stimuli associated with the initial fear learning, while little attention has been paid to fear return evoked after exposure to an unconditioned stressor. This study explored the neural mechanisms of fear return induced by elevated platform (EP) stressor in Sprague-Dawley rats initially subjected to auditory fear conditioning. The contributions of the prelimbic cortex (PL), dorsal hippocampus (DH), ventral hippocampus (VH), and basolateral amygdala (BLA) were examined by targeted bilateral intracerebral injection of the GABA(A) agonist muscimol after elevated platform (EP) stressor. Muscimol-induced inactivation of PL or BLA significantly impaired the return of conditioning fear, while inactivation of the DH or VH had no effect. These results suggest that fear return induced by non-associative stressor may depend on the PL and BLA but not on the hippocampus.

KeywordElevated platform stressor Prelimbic cortex (PL) Dorsal and ventral hippocampus (DH & VH) Basolateral amygdala (BLA) Fear conditioning
2021-06-15
Language英语
DOI10.1016/j.brainres.2021.147398
Source PublicationBRAIN RESEARCH
ISSN0006-8993
Volume1761Pages:10
Subtype综述
Indexed BySCI
Funding ProjectEvaluation and Intervention Technology Research for Post-traumatic Stress Patients Population[JCYJ20170413170301569] ; Pioneer Initiative of the Chinese Academy of Sciences, Feature Institutes Program[TSS-2015-06] ; CAS key Laboratory of Mental Health, Institute of Psychology ; doctor foundation of Binzhou University, China[2016Y18] ; Major projects of Binzhou University, China[2020ZD01] ; Research project of Humanities and Social Sciences in Henan Province[2021-ZZJH-057]
PublisherELSEVIER
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000636051300010
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/38871
Collection中国科学院心理健康重点实验室
Corresponding AuthorZheng, Xigeng
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Henan Univ, Sch Educ Sci, Kaifeng 475004, Henan, Peoples R China
3.Binzhou Univ, Coll Biol & Environm Engn, Binzhou 256600, Shandong, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Xing, Xiaoli,Fu, Juan,Wang, Hongbo,et al. Contributions of prelimbic cortex, dorsal and ventral hippocampus, and basolateral amygdala to fear return induced by elevated platform stress in rats[J]. BRAIN RESEARCH,2021,1761:10.
APA Xing, Xiaoli,Fu, Juan,Wang, Hongbo,&Zheng, Xigeng.(2021).Contributions of prelimbic cortex, dorsal and ventral hippocampus, and basolateral amygdala to fear return induced by elevated platform stress in rats.BRAIN RESEARCH,1761,10.
MLA Xing, Xiaoli,et al."Contributions of prelimbic cortex, dorsal and ventral hippocampus, and basolateral amygdala to fear return induced by elevated platform stress in rats".BRAIN RESEARCH 1761(2021):10.
Files in This Item:
File Name/Size DocType Version Access License
Contributions of pre(4572KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Xing, Xiaoli]'s Articles
[Fu, Juan]'s Articles
[Wang, Hongbo]'s Articles
Baidu academic
Similar articles in Baidu academic
[Xing, Xiaoli]'s Articles
[Fu, Juan]'s Articles
[Wang, Hongbo]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xing, Xiaoli]'s Articles
[Fu, Juan]'s Articles
[Wang, Hongbo]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.