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Dyskinesia is Closely Associated with Synchronization of Theta Oscillatory Activity Between the Substantia Nigra Pars Reticulata and Motor Cortex in the Off L-dopa State in Rats | |
Chen, Jiazhi1; Wang, Qiang1,3; Li, Nanxiang1; Huang, Shujie1; Li, Min1; Cai, Junbin1; Wang, Yuzheng2; Wen, Huantao1; Lv, Siyuan1; Wang, Ning2; Wang, Jinyan2; Luo, Fei2; Zhang, Wangming1 | |
第一作者 | Chen, Jiazhi |
通讯作者邮箱 | luof@psych.ac.cn (fei luo) ; wzhang@vip.126.com (wangming zhang ) |
心理所单位排序 | 2 |
摘要 | Excessive theta (theta) frequency oscillation and synchronization in the basal ganglia (BG) has been reported in elderly parkinsonian patients and animal models of levodopa (L-dopa)-induced dyskinesia (LID), particularly the theta oscillation recorded during periods when L-dopa is withdrawn (the off L-dopa state). To gain insight into processes underlying this activity, we explored the relationship between primary motor cortex (M1) oscillatory activity and BG output in LID. We recorded local field potentials in the substantia nigra pars reticulata (SNr) and M1 of awake, inattentive resting rats before and after L-dopa priming in Sham control, Parkinson disease model, and LID model groups. We found that chronic L-dopa increased theta synchronization and information flow between the SNr and M1 in off L-dopa state LID rats, with a SNr-to-M1 flow directionality. Compared with the on state, theta oscillational activity (theta synchronization and information flow) during the off state were more closely associated with abnormal involuntary movements. Our findings indicate that theta oscillation in M1 may be consequent to abnormal synchronous discharges in the BG and support the notion that M1 theta oscillation may participate in the induction of dyskinesia. |
关键词 | Parkinson's disease Dyskinesia Substantia nigra pars reticulata Primary motor cortex Synchronization |
2021-03-01 | |
语种 | 英语 |
DOI | 10.1007/s12264-020-00606-3 |
发表期刊 | NEUROSCIENCE BULLETIN |
ISSN | 1673-7067 |
卷号 | 37期号:3页码:323-338 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China[81771210] ; Natural Science Foundation of Guangdong Province, China[2015A030313288] |
出版者 | SPRINGER |
WOS研究方向 | Neurosciences & Neurology |
WOS类目 | Neurosciences |
WOS记录号 | WOS:000638245400001 |
WOS分区 | Q2 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/38901 |
专题 | 中国科学院心理健康重点实验室 健康与遗传心理学研究室 |
通讯作者 | Luo, Fei; Zhang, Wangming |
作者单位 | 1.Southern Med Univ, Zhujiang Hosp, Dept Neurosurg,Guangdong Prov Key Lab Brain Funct, Engn Technol Res Ctr,Natl Key Clin Specialty,Mini, Guangzhou 510282, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 3.Charite Univ Med Berlin, Dept Neurol, Movement Disorders & Neuromodulat Unit, D-10117 Berlin, Germany |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Chen, Jiazhi,Wang, Qiang,Li, Nanxiang,et al. Dyskinesia is Closely Associated with Synchronization of Theta Oscillatory Activity Between the Substantia Nigra Pars Reticulata and Motor Cortex in the Off L-dopa State in Rats[J]. NEUROSCIENCE BULLETIN,2021,37(3):323-338. |
APA | Chen, Jiazhi.,Wang, Qiang.,Li, Nanxiang.,Huang, Shujie.,Li, Min.,...&Zhang, Wangming.(2021).Dyskinesia is Closely Associated with Synchronization of Theta Oscillatory Activity Between the Substantia Nigra Pars Reticulata and Motor Cortex in the Off L-dopa State in Rats.NEUROSCIENCE BULLETIN,37(3),323-338. |
MLA | Chen, Jiazhi,et al."Dyskinesia is Closely Associated with Synchronization of Theta Oscillatory Activity Between the Substantia Nigra Pars Reticulata and Motor Cortex in the Off L-dopa State in Rats".NEUROSCIENCE BULLETIN 37.3(2021):323-338. |
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