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Brain activation during verbal fluency task in type II bipolar disorder patients: a near-infrared spectroscopy study
Chen, Gui-fang1; Mao, Meng-chai4,5; Feng, Kun1; Gan, Jie-chun1; Zhang, Xiao-qian1; Shen, Chen-yu1; Xu, Bo1; Liu, Xiao-min6; Ren, Xia-Jin1; Liu, Po-Zi1; Wang, Ya2,3
First AuthorChen, Gui-fang ; Mao, Meng-chai ; Feng, Kun
Correspondent Emailliupozi@mail.tsinghua.edu.cn (p.-z. liu) ; wangyazsu@gmail.com, wangya@psych.ac.cn (y. wang)
Contribution Rank2
Abstract

Background: Previous studies have shown that BD patients exhibited impairment when performing a verbal fluency task (VFT) and abnormal prefrontal cortex activation during this task. However, no study has specifically examined whether patients with type II BD demonstrate difficulty in performing VFT and impairments in relevant neural correlates or whether these are related to psychotic symptoms, the present study aimed to examine these issues. Methods: Forty-nine patients with type II BD (21 patients with psychotic symptoms [BDIIp] and 28 patients without psychotic symptoms [BDIIn]) and 45 matched healthy controls (HCs) participated the study and completed the VFTs, while their brain activity was recorded with near-infrared spectroscopy (NIRS). Results: Both BDIIp and BDIIn patients showed poorer performance on VFTs than HCs. In addition, BDII patients showed lower brain activation than HCs in bilateral dorsolateral prefrontal cortex and right frontal pole, these results were mainly driven by BDIIn patients. Moreover, subjective psychotic symptoms were positively significantly correlated with left dorsolateral prefrontal cortex activation in BDII patients. Conclusions: Type II BD patients showed significant impairment when performing VFTs and reduced activation in the prefrontal cortex, and subjective psychotic symptoms were associated with brain activation in left dorsolateral prefrontal cortex in BDII patients.

KeywordNear infrared spectroscopy Type II bipolar disorder Verbal fluency Psychotic symptoms
2021-04-01
DOI10.1016/j.psychres.2021.113762
Source PublicationPSYCHIATRY RESEARCH
ISSN0165-1781
Volume298Pages:8
Subtype实证研究
Indexed BySCI ; SSCI
PublisherELSEVIER IRELAND LTD
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000634552600038
WoS QuartileQ2
QuartileQ2
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/38925
Collection中国科学院心理健康重点实验室
Corresponding AuthorLiu, Po-Zi; Wang, Ya
Affiliation1.Tsinghua Univ, YuQuan Hosp, Sch Clin Med, Beijing, Peoples R China
2.Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Shanghai Univ Tradit Chinese Med, Shanghai, Peoples R China
5.Minist Educ, Engn Res Ctr Tradit Chinese Med Intelligent Rehab, Beijing, Peoples R China
6.Capital Med Univ, Beijing Shijitan Hosp, Dept Neurol & Psychiat, Beijing, Peoples R China
Corresponding Author Affilication认知与发展心理学研究室
Recommended Citation
GB/T 7714
Chen, Gui-fang,Mao, Meng-chai,Feng, Kun,et al. Brain activation during verbal fluency task in type II bipolar disorder patients: a near-infrared spectroscopy study[J]. PSYCHIATRY RESEARCH,2021,298:8.
APA Chen, Gui-fang.,Mao, Meng-chai.,Feng, Kun.,Gan, Jie-chun.,Zhang, Xiao-qian.,...&Wang, Ya.(2021).Brain activation during verbal fluency task in type II bipolar disorder patients: a near-infrared spectroscopy study.PSYCHIATRY RESEARCH,298,8.
MLA Chen, Gui-fang,et al."Brain activation during verbal fluency task in type II bipolar disorder patients: a near-infrared spectroscopy study".PSYCHIATRY RESEARCH 298(2021):8.
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