PSYCH OpenIR  > 中国科学院心理健康重点实验室
Altered cortico-striatal functional connectivity in people with high levels of schizotypy: A longitudinal resting-state study
Wang, Ling-ling1,2; Sun, Xiaoqi3; Chiu, Chui-De3; Leung, Patrick W. L.3; Chan, Raymond C. K.1,2; So, Suzanne H. W.3
First AuthorWang, Ling-ling
Correspondent Emailrckchan@psych.ac.cn (r.c.k. chan) ; shwso@psy.cuhk.edu.hk (s.h.w. so)
Contribution Rank1
Abstract

Purpose of the research: Cortico-striatal functional connectivity has been implicated in the neuropathology of schizophrenia. However, the longitudinal relationship between the cortico-striatal connectivity and schizotypy remains unknown. We examined the resting-state fMRI connectivity in 27 individuals with a high level of schizotypy and 20 individuals with a low level of schizotypy at baseline and 18 months later. Correlations between changes in cortico-striatal connectivity and changes in schizotypy scores over time were examined. Principal results: We found both increased and decreased cortico-striatal connectivity in individuals with a high level of schizotypy at baseline. Over time, these individuals showed improvement in both the negative and positive schizotypal domains. Changes in striatal-insula connectivity were positively correlated with changes in positive schizotypy from baseline to follow-up. Major conclusions: Our results suggested impaired cortico-striatal connectivity in individuals with a high level of schizotypy. The dysconnectivity mainly involves the dorsal striatum. The connectivity between the dorsal striatum and the insula may be a putative marker for temporal changes in positive schizotypy.

KeywordSchizotypy Cortico-striatal connectivity Resting-state fMRI
2021-04-01
Language英语
DOI10.1016/j.ajp.2021.102621
Source PublicationASIAN JOURNAL OF PSYCHIATRY
ISSN1876-2018
Volume58Pages:7
Subtype实证研究
Indexed BySCI
Funding ProjectChinese University of Hong Kong ; Research Grants Council[14605717] ; Research Grants Council[14612519] ; National Key Research and Development Programme[2016YFC0906402] ; CAS Key Laboratory of Mental Health, Institute of Psychology
PublisherELSEVIER
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000634338300007
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/38943
Collection中国科学院心理健康重点实验室
Corresponding AuthorChan, Raymond C. K.; So, Suzanne H. W.
Affiliation1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Chinese Univ Hong Kong, Dept Psychol, Hong Kong, Peoples R China
First Author Affilication认知与发展心理学研究室
Corresponding Author Affilication认知与发展心理学研究室
Recommended Citation
GB/T 7714
Wang, Ling-ling,Sun, Xiaoqi,Chiu, Chui-De,et al. Altered cortico-striatal functional connectivity in people with high levels of schizotypy: A longitudinal resting-state study[J]. ASIAN JOURNAL OF PSYCHIATRY,2021,58:7.
APA Wang, Ling-ling,Sun, Xiaoqi,Chiu, Chui-De,Leung, Patrick W. L.,Chan, Raymond C. K.,&So, Suzanne H. W..(2021).Altered cortico-striatal functional connectivity in people with high levels of schizotypy: A longitudinal resting-state study.ASIAN JOURNAL OF PSYCHIATRY,58,7.
MLA Wang, Ling-ling,et al."Altered cortico-striatal functional connectivity in people with high levels of schizotypy: A longitudinal resting-state study".ASIAN JOURNAL OF PSYCHIATRY 58(2021):7.
Files in This Item:
File Name/Size DocType Version Access License
Altered cortico-stri(703KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, Ling-ling]'s Articles
[Sun, Xiaoqi]'s Articles
[Chiu, Chui-De]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, Ling-ling]'s Articles
[Sun, Xiaoqi]'s Articles
[Chiu, Chui-De]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, Ling-ling]'s Articles
[Sun, Xiaoqi]'s Articles
[Chiu, Chui-De]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.