中国科学院心理健康重点实验室知识库

目的研究醒脾解郁方对轻中度抑郁症肝郁脾虚证患者的临床疗效。方法选择2018年7月—2019年1月就诊于北京中医药大学东方医院的抑郁症肝郁脾虚证患者,共61例,按入组时间顺序编号,随机分为对照组30例和试验组31例,对照组给予中药安慰剂(醒脾解郁颗粒模拟剂),试验组给予醒脾解郁方配方颗粒。2组患者均每日服药1剂,上下午分服,共治疗6周,比较2组患者汉密尔顿抑郁量表(HAMD-24)、汉密尔顿焦虑量表(HAMA)、抑郁自评量表(SDS)、焦虑自评量表(SAS)、抑郁症中医证候要素量表分数变化情况,治疗前后外周血腺嘌呤核苷三磷酸(ATP)、腺嘌呤核苷二磷酸(ADP)、腺嘌呤核糖核苷酸(AMP)含量变化情况以及不良反应发生情况。结果临床疗效:与治疗前比较,对照组患者治疗后的HAMD-24总分以及焦虑/躯体化、认知障碍、日夜变化、阻滞、绝望感5类因子,SDS总分,中医证候气虚与气滞分数降低(P<0.05),HAMD-24评分总有效率为93.55%(显效率为70.97%)。在作用机制方面:与治疗前比较,对照组治疗后外周血AMP含量升高(P<0.05);试验组治疗后外周血ATP含量升高(P

To study the effects of Xingpi Jieyu Formula on mild to moderate depression of liver depression and spleen deficiency pattern． Methods 61 patients with depression of liver depression and spleen deficiency pattern who volunteered to participate in the study from July 2018 to January 2019 were randomly divided into control group ( 30 cases) and experimental group ( 31 cases) according to the time sequence． The control group was treated with placebo ( Xingpi Jieyu granule simulant) and the experimental group was treated with Xingpi Jieyu formula granules． Both groups took 1 dose daily and took separately in the morning and afternoon After 6 weeks of treatment，HAMD-24，HAMA，SDS，SAS，TCM syndrome factor scale scores of depression were compared between the two groups，and the changes of ATP，ADP，amp contents in peripheral blood of the two groups before and after treatment，as well as the occurrence of adverse reactions were compared． Ｒesults In terms of clinical efficacy: compared with before treatment， the total scores of HAMD-24， five factor scores of “anxiety /somatization，cognitive impairment，day and night change，block and sense of despair”，SDS score，qi deficiency and qi stagnation pattern scores were reduced in the control group ( P ＜ 0． 05 ) ; the total scores of HAMD-24，six factor scores，gastrointestinal and general symptoms，HAMA total scores，somatic and psychological scores，SDS score，SAS score，and pattern scores of qi deficiency，qi stagnation and phlegm dampness were significantly lower than those before treatment in the experimental group ( P ＜ 0． 05 ) ． The total effective rate of HAMD score was 93． 55% ( 70． 97% markedly effective) ． In terms of mechanism of action: compared with before treatment，peripheral serum AMP increased in the control group ( P ＜ 0． 05) ; ATP increased in the experimental group after treatment ( P＜ 0． 05 ) ; in terms of safety profile，1 patient in control group had nausea，and 2 patients in the experimental group had nausea diarrhea． All symptoms disappeared on its own shortly ( 2 － 3 days) ．No cases of liver and kidney injury． Conclusion Compared with placebo，Xingpi Jieyu Formula could significantly improve depression and somatic symptoms of depressive patients， and can increase peripheral blood ATP level．

国家自然科学基金项目(No.81573843,No.81874422)~~