PSYCH OpenIR  > 中国科学院心理健康重点实验室
Cortical and Subcortical Neuroanatomical Signatures of Schizotypy in 2,952 Individuals Assessed in a Worldwide ENIGMA Study
Kirschner, Matthias1; Hodzic-Santor, Benazir2; Antoniades, Mathilde3; Nenadic, Igor4; Kircher, Tilo5; Krug, Axel5,6; Fornito, Alex6; Arnatkeviciute, Aurina; Dannlowski, Udo7; DeRosse, Pamela8; Baune, Bernhard T.7; Green, Melissa9; Quide, Yann10; Pantelis, Christos11; Chan, Raymond12; Ettinger, Ulrich13; Debbane, Martin14; Derome, Melodie14; Gaser, Christian15; Besteher, Bianca15; Diederen, Kelly16; Spencer, Tom J.16; Fletcher, Paul17; Roessler, Wulf18; Kumari, Veena19; Park, Haeme20; Lemmers-Jansen, Imke21; Gilleen, James22; Allen, Paul23; Marsman, Jan-Bernard24; Lebedeva, Irina25; Kaiser, Stefan26; Fett, Anne-Kathrin27; Sommer, Iris28; Lariviere, Sara29; Bernhardt, Boris C.29; Dagher, Alain2; van Erp, Theo G. M.30; Turner, Jessica A.31; Thompson, Paul M.32; Aleman, Andre24
First AuthorKirschner, Matthias
Abstract

Neuroanatomical abnormalities have been reported along a continuum from at-risk stages, including high schizotypy, to early and chronic psychosis. However, a comprehensive neuroanatomical mapping of schizotypy remains to be established. The authors conducted the first large-scale meta-analyses of cortical and subcortical morphometric patterns of schizotypy in healthy individuals, and compared these patterns with neuroanatomical abnormalities observed in major psychiatric disorders. The sample comprised 3,004 unmedicated healthy individuals (12-68 years, 46.5% male) from 29 cohorts of the worldwide ENIGMA Schizotypy working group. Cortical and subcortical effect size maps with schizotypy scores were generated using standardized methods. Pattern similarities were assessed between the schizotypy-related cortical and subcortical maps and effect size maps from comparisons of schizophrenia (SZ), bipolar disorder (BD) and major depression (MDD) patients with controls. Thicker right medial orbitofrontal/ventromedial prefrontal cortex (mOFC/vmPFC) was associated with higher schizotypy scores (r=.07, pFDR=.02). The cortical thickness profile in schizotypy was positively correlated with cortical abnormalities in SZ (r=.33, pspin=.01), but not BD (r=.19, pspin=.16) or MDD (r=-.22, pspin=.10). The schizotypy-related subcortical volume pattern was negatively correlated with subcortical abnormalities in SZ (rho=-.65, pspin=.01), BD (rho=-.63, pspin=.01), and MDD (rho=-.69, pspin=.004). Comprehensive mapping of schizotypy-related brain morphometry in the general population revealed a significant relationship between higher schizotypy and thicker mOFC/vmPFC, in the absence of confounding effects due to antipsychotic medication or disease chronicity. The cortical pattern similarity between schizotypy and schizophrenia yields new insights into a dimensional neurobiological continuity across the extended psychosis phenotype.

KeywordMR Structural Imaging Schizotypy Psychosis Continuum Meta-Analysis Cortical Thickness
2021-05-01
Source PublicationBIOLOGICAL PSYCHIATRY
ISSN0006-3223
Volume89Issue:9Pages:S182-S182
Subtype实证研究
Indexed BySCI
Funding ProjectSwiss National Foundation[P2SKP3_178175]
PublisherELSEVIER SCIENCE INC
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectNeurosciences ; Psychiatry
WOS IDWOS:000645683800438
WoS QuartileQ1
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/39065
Collection中国科学院心理健康重点实验室
Affiliation1.Univ Zurich, Psychiat Hosp, Zurich, Switzerland
2.McGill Univ, Montreal Neurol Inst, Montreal, PQ, Canada
3.Icahn Sch Med Mt Sinai, New York, NY 10029 USA
4.Philipps Univ Marburg, Marburg, Germany
5.Univ Marburg, Marburg, Germany
6.Monash Univ, Clayton, Vic, Australia
7.Univ Munster, Munster, Germany
8.Zucker Hillside Hosp, Northwell Hlth, New York, NY USA
9.Univ New South Wales, Sydney, NSW, Australia
10.Univ New South Wales, Sch Psychiat, Neurosci Res Australia, Sydney, NSW, Australia
11.Univ Melbourne, Melbourne Neuropsychiat Ctr, Melbourne, Vic, Australia
12.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
13.Univ Bonn, Bonn, Germany
14.Univ Geneva, Geneva, Switzerland
15.Jena Univ Hosp, Jena, Germany
16.Kings Coll London, London, England
17.Univ Cambridge, Cambridge, England
18.Univ Zurich, Zurich, Switzerland
19.Brunel Univ London, London, England
20.Univ Auckland, Auckland, New Zealand
21.Free Univ Amsterdam, Amsterdam, Netherlands
22.Univ Roehampton, KCL, London, England
23.Univ Roehampton, London, England
24.Univ Groningen, Groningen, Netherlands
25.Russian Acad Med Sci, Mental Hlth Res Ctr, Moscow, Russia
26.Geneva Univ Hosp, Geneva, Switzerland
27.City Univ London, London, England
28.Univ Med Ctr Groningen, Groningen, Netherlands
29.McGill Univ, Montreal Neurol Inst, Multimodal Imaging & Connect Anal Lab, Montreal, PQ, Canada
30.Univ Calif Berkeley, Berkeley, CA 94720 USA
31.Georgia State Univ, Neurosci Inst, Atlanta, GA 30303 USA
32.Univ Southern Calif, Keck Sch Med, Imaging Genet Ctr, Los Angeles, CA 90007 USA
33.Kings Coll London, Inst Psychiat, London, England
Recommended Citation
GB/T 7714
Kirschner, Matthias,Hodzic-Santor, Benazir,Antoniades, Mathilde,et al. Cortical and Subcortical Neuroanatomical Signatures of Schizotypy in 2,952 Individuals Assessed in a Worldwide ENIGMA Study[J]. BIOLOGICAL PSYCHIATRY,2021,89(9):S182-S182.
APA Kirschner, Matthias.,Hodzic-Santor, Benazir.,Antoniades, Mathilde.,Nenadic, Igor.,Kircher, Tilo.,...&Aleman, Andre.(2021).Cortical and Subcortical Neuroanatomical Signatures of Schizotypy in 2,952 Individuals Assessed in a Worldwide ENIGMA Study.BIOLOGICAL PSYCHIATRY,89(9),S182-S182.
MLA Kirschner, Matthias,et al."Cortical and Subcortical Neuroanatomical Signatures of Schizotypy in 2,952 Individuals Assessed in a Worldwide ENIGMA Study".BIOLOGICAL PSYCHIATRY 89.9(2021):S182-S182.
Files in This Item:
File Name/Size DocType Version Access License
Cortical and Subcort(532KB)期刊论文作者接受稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Kirschner, Matthias]'s Articles
[Hodzic-Santor, Benazir]'s Articles
[Antoniades, Mathilde]'s Articles
Baidu academic
Similar articles in Baidu academic
[Kirschner, Matthias]'s Articles
[Hodzic-Santor, Benazir]'s Articles
[Antoniades, Mathilde]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Kirschner, Matthias]'s Articles
[Hodzic-Santor, Benazir]'s Articles
[Antoniades, Mathilde]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.