The Role of Corticolimbic Circuitry in Chronic Pain

doi:10.16476/j.pibb.2020.0195

	The Role of Corticolimbic Circuitry in Chronic Pain
	Wang Fei-Xue 1,2; Bi Yan-Zhi 1,3; Hu Li1,3
通讯作者	Bi Yan-Zhi(biyz@psych.ac.cn)
摘要	Chronic pain is one of the most common clinical symptoms and has been considered as a global healthcare problem. Currently, the underlying mechanisms of the transition from acute to chronic pain, also known as pain chronification, still remain incompletely understood. Neuroimaging studies indicated that the corticolimbic circuitry (prefrontal cortex, amygdala, hippocampus, nucleus accumbens, ventral tegmental area) is preferentially involved in encoding fluctuations of ongoing pain for various chronic pain conditions, suggesting the critical role of this neural circuitry in pain chronification. In this review, we first summarized the emotion, motivation, and memory dysfunctions and their corresponding structural and functional changes of the corticolimbic circuitry in chronic pain patients. Then, we reviewed the longitudinal brain imaging studies on low back pain chronification and highlighted the neuroimaging variables (i. e., the structural and functional properties of the corticolimbic circuitry) that could predict the transition from acute to chronic pain. For example, the functional connectivity between the medial prefrontal cortex and nucleus accumbens/hippocampus, as well as the functional connectivity between the dorsal medial prefrontal cortex and amygdala/nucleus accumbens could predict the development of chronic pain 1 year later. Besides, based on the existing theoretical model of chronic pain, we emphasized the critical role of the reinforcement learning of negative emotions as well as the dysfunctions of reward and stress systemin pain chronification. Finally, we pointed out the limitations of previous studies in this field and suggested future research directions for a better understanding of the neural mechanisms of chronic pain and pain chronification.
关键词	pain chronification emotion motivation corticolimbic circuitry
	2021-04-01
语种	英语
DOI	10.16476/j.pibb.2020.0195
发表期刊	PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
ISSN	1000-3282
卷号	48 期号:4 页码:393-406
收录类别	SCI
资助项目	National Natural Science Foundation of China[31800926] ; National Natural Science Foundation of China[31671141] ; National Natural Science Foundation of China[31822025] ; China Postdoctoral Science Foundation[2018M640191] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[Y8CX351005] ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2018ZG01]
出版者	CHINESE ACAD SCIENCES, INST BIOPHYSICS
WOS关键词	CHRONIC BACK-PAIN ; MEDIAL PREFRONTAL CORTEX ; GRAY-MATTER LOSS ; FUNCTIONAL CONNECTIVITY ; BRAIN MECHANISMS ; FIBROMYALGIA PATIENTS ; COGNITIVE IMPAIRMENT ; ALTERED STRUCTURE ; EMOTIONAL BRAIN ; MEMORY TRACES
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:000644196400005
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/39081
专题	中国科学院心理健康重点实验室
通讯作者	Bi Yan-Zhi
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Liaoning Normal Univ, Res Ctr Brain Cognit Neurosci, Dalian 116029, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
通讯作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Wang Fei-Xue,Bi Yan-Zhi,Hu Li. The Role of Corticolimbic Circuitry in Chronic Pain[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2021,48(4):393-406.
APA	Wang Fei-Xue,Bi Yan-Zhi,&Hu Li.(2021).The Role of Corticolimbic Circuitry in Chronic Pain.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,48(4),393-406.
MLA	Wang Fei-Xue,et al."The Role of Corticolimbic Circuitry in Chronic Pain".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 48.4(2021):393-406.