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An ERP study on proactive and reactive response inhibition in individuals with schizotypy
Jia, Lu-xia1,2; Qin, Xiao-jing1,2; Cui, Ji-fang3; Zheng, Qi1,2; Yang, Tian-xiao1,2; Wang, Ya1,2; Chan, Raymond CK1,2
First AuthorJia, Lu-xia
Corresponding AuthorWang, Ya(wangya@psych.ac.cn)
Correspondent Emailwangya@psych.ac.cn (ya wang)
Contribution Rank1
Abstract

Schizotypy, a subclinical group at risk for schizophrenia, has been found to show impairments in response inhibition. However, it remains unclear whether this impairment is accompanied by outright stopping (reactive inhibition) or preparation for stopping (proactive inhibition). We recruited 20 schizotypy and 24 non-schizotypy individuals to perform a modified stop-signal task with electroencephalographic (EEG) data recorded. This task consists of three conditions based on the probability of stop signal: 0% (no stop trials, only go trials), 17% (17% stop trials), and 33% (33% stop trials), the conditions were indicated by the colour of go stimuli. For proactive inhibition (go trials), individuals with schizotypy exhibited significantly lesser increase in go response time (RT) as the stop signal probability increasing compared to non-schizotypy individuals. Individuals with schizotypy also exhibited significantly increased N1 amplitude on all levels of stop signal probability and increased P3 amplitude in the 17% stop condition compared with non-schizotypy individuals. For reactive inhibition (stop trials), individuals with schizotypy exhibited significantly longer stop signal reaction time (SSRT) in both 17% and 33% stop conditions and smaller N2 amplitude on stop trials in the 17% stop condition than non-schizotypy individuals. These findings suggest that individuals with schizotypy were impaired in both proactive and reactive response inhibition at behavioural and neural levels.

2021
Language英语
DOI10.1038/s41598-021-87735-5
Source PublicationScientific Reports
ISSN2045-2322
Volume11Issue:1Pages:8394
Subtype实证研究
Indexed BySCI
Funding ProjectMOST Precise Psychiatry project[2016YFC0906402] ; National Science Foundation[31571130] ; National Science Foundation[32071062]
PublisherNATURE RESEARCH
WOS KeywordSTOP-SIGNAL PROBABILITY ; ELECTROPHYSIOLOGICAL EVIDENCE ; COGNITIVE CONTROL ; N2/P3 COMPLEX ; SCHIZOPHRENIA ; CORTEX ; DISCRIMINATION ; PERSONALITY ; BRAIN ; P300
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000641799700025
WoS QuartileQ1
QuartileQ1
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/39225
Collection中国科学院心理健康重点实验室
健康与遗传心理学研究室
Corresponding AuthorWang, Ya
Affiliation1.Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
2.Department of Psychology, University of Chinese Academy of Sciences
3.Research Center for Information and Statistics, National Institute of Education Sciences, Beijing, China
First Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Jia, Lu-xia,Qin, Xiao-jing,Cui, Ji-fang,et al. An ERP study on proactive and reactive response inhibition in individuals with schizotypy[J]. Scientific Reports,2021,11(1):8394.
APA Jia, Lu-xia.,Qin, Xiao-jing.,Cui, Ji-fang.,Zheng, Qi.,Yang, Tian-xiao.,...&Chan, Raymond CK.(2021).An ERP study on proactive and reactive response inhibition in individuals with schizotypy.Scientific Reports,11(1),8394.
MLA Jia, Lu-xia,et al."An ERP study on proactive and reactive response inhibition in individuals with schizotypy".Scientific Reports 11.1(2021):8394.
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