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Increased cocaine motivation in tree shrews is modulated by striatal dopamine D1 receptor-mediated upregulation of Ca(v)1.2 | |
Duan, Ying1,2; Meng, Yiming1,2; Du, Wenjie1,2; Li, Ming3; Zhang, Jianjun1,2; Liang, Jing1,2; Li, Yonghui1,2; Sui, Nan1,2; Shen, Fang1,2 | |
第一作者 | Duan, Ying ; Meng, Yiming |
通讯作者邮箱 | suin@psych.ac.cn ; shenf@psych.ac.cn |
心理所单位排序 | 1 |
摘要 | The progressively increased motivation for cocaine during abstinence is closely associated with the dysfunction of dopamine (DA) system. As DA receptors also dynamically regulate L-type calcium channels (LTCCs), in this study we examined how DA receptors (D1R or D2R) and LTCCs (Ca(v)1.2 or Ca(v)1.3) exert their influences on cocaine-seeking in a tree shrew (Tupaia belangeri chinensis) model. First, we demonstrated the 'incubation' effect by showing tree shrews exhibited a significantly higher seeking behaviour on withdrawal day (WD) 45 than on WD1. Then, we confirmed that longer abstinence period induced higher D1R expression in the nucleus accumbens (NAc). Next, we showed that LTCCs in the NAc participated in drug seeking. Moreover, Ca(v)1.2 expression in the NAc was increased on WD45, and disruption of the Ca(v)1.2 inhibited drug seeking. Finally, we found that D1R antagonist blocked the increase of Ca(v)1.2 on drug-seeking test. Collectively, these findings suggest that D1R-mediated upregulation of Ca(v)1.2 is involved in the incubation of cocaine craving. |
关键词 | cocaine dopamine receptors incubation of craving L‐ type calcium channels motivation tree shrews |
2021-05-13 | |
DOI | 10.1111/adb.13053 |
发表期刊 | ADDICTION BIOLOGY |
ISSN | 1355-6215 |
页码 | 11 |
收录类别 | SCI |
出版者 | WILEY |
WOS关键词 | RAT NUCLEUS-ACCUMBENS ; LONG-TERM ADAPTATION ; MEDIUM SPINY NEURONS ; CALCIUM-CHANNELS ; CA2+ CHANNELS ; GLUA1 TRAFFICKING ; NMDA RECEPTORS ; AMPA RECEPTORS ; INCUBATION ; D2 |
WOS研究方向 | Biochemistry & Molecular Biology ; Substance Abuse ; Biochemistry & Molecular Biology ; Substance Abuse |
WOS记录号 | WOS:000649981400001 |
WOS分区 | Q1 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/39230 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Sui, Nan; Shen, Fang |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Univ Nebraska Lincoln, Dept Psychol, Lincoln, NE USA |
第一作者单位 | 中国科学院心理健康重点实验室 |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Duan, Ying,Meng, Yiming,Du, Wenjie,et al. Increased cocaine motivation in tree shrews is modulated by striatal dopamine D1 receptor-mediated upregulation of Ca(v)1.2[J]. ADDICTION BIOLOGY,2021:11. |
APA | Duan, Ying.,Meng, Yiming.,Du, Wenjie.,Li, Ming.,Zhang, Jianjun.,...&Shen, Fang.(2021).Increased cocaine motivation in tree shrews is modulated by striatal dopamine D1 receptor-mediated upregulation of Ca(v)1.2.ADDICTION BIOLOGY,11. |
MLA | Duan, Ying,et al."Increased cocaine motivation in tree shrews is modulated by striatal dopamine D1 receptor-mediated upregulation of Ca(v)1.2".ADDICTION BIOLOGY (2021):11. |
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2021 AB Increased co(2941KB) | 期刊论文 | 作者接受稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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