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Prevalence and risk factors of overweight and obesity in Chinese patients with first-episode drug-na?ve major depressive disorder
Si, Tong1; Yang, Kun2; Lang, XiaoE3; Dong, Xinglu4; Wang, Ningqun1; Zhang, Xiangyang5,6; Qu, Miao1
First AuthorSi, Tong
Correspondent Emailzhangxy@psych.ac.cn (x. zhang) ; qumiaotcm@126.com (m. qu)
Contribution Rank5
Abstract

Backgrounds: Obesity and overweight are common in patients with major depressive disorder (MDD); the results are inconsistent due to confounding variables involved in studies. Furthermore, no well-designed study has been published to investigate the prevalence, risk factors and underlying mechanisms of obesity/overweight in Chinese MDD patients. This study aimed to investigate the prevalence of obesity/overweight and related risk factors in first-episode, drug-na & iuml;ve (FEDN) patients with MDD in China.& nbsp; Methods: A total of 1718 patients were recruited. Their clinical and anthropometric data, thyroid function and biochemical parameters were collected. All patients were evaluated on the 17-item Hamilton Rating Scale for Depression, 14-item Hamilton Anxiety Rating Scale and the Positive and Negative Syndrome Scale.& nbsp; & nbsp;Results: The prevalence of obesity and overweight was 3.73% and 56.00%, respectively. Multivariable logistic regression analysis showed that TSH was the only independent risk factor for weight gain in MDD patents. The fitting curve of the relationship between TSH and BMI formed an inverted U-shaped parabola. The ordinal logit mode showed that when TSH<=2.68 was set as a reference, the odd rates of weight increased with the increase of TSH, and the highest rate was 3.929 (95%CI: 2.879 & ndash;5.361, P<0.0001).& nbsp; Limitation: Causality cannot be drawn due to cross-sectional design.& nbsp; Conclusion: Our results suggest that overweight is very common among patients with FEDN MDD rather than obesity. TSH is a promising predictor and potential biomarker of high weight in MDD patients, and there is an inverted U-shaped parabolic relationship between TSH and BMI.

KeywordMajor depressive disorder Obesity Overweight Thyroid stimulating hormone
2021-05-01
DOI10.1016/j.jad.2021.01.037
Source PublicationJOURNAL OF AFFECTIVE DISORDERS
ISSN0165-0327
Volume286Pages:351-359
Subtype实证研究
Indexed BySCI
Funding ProjectNational Key R&D Program of China[2020YFC2003100] ; National Key R&D Program of China[2020YFC2003103] ; National Natural Science Foundation of China[81973759] ; National Natural Science Foundation of China[81573905] ; Capital's Funds for Health Improvement and Research[SF2020-1-2011]
PublisherELSEVIER
WOS KeywordBODY-MASS INDEX ; NATIONAL COMORBIDITY SURVEY ; THYROID AUTOIMMUNITY ; US ADULTS ; ASSOCIATION ; ANXIETY ; WEIGHT ; EPIDEMIOLOGY ; SYMPTOMS ; OUTCOMES
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectClinical Neurology ; Psychiatry
WOS IDWOS:000640645300010
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/39284
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhang, Xiangyang; Qu, Miao
Affiliation1.Capital Med Univ, Xuanwu Hosp, Dept Neurol, 45 Changchun St, Beijing 100053, Peoples R China
2.Capital Med Univ, Xuanwu Hosp, Dept Evidence Based Med, Beijing, Peoples R China
3.Shanxi Med Univ, Clin Med Coll 1, Dept Psychiat, Taiyuan, Shanxi, Peoples R China
4.Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Neurol, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Si, Tong,Yang, Kun,Lang, XiaoE,et al. Prevalence and risk factors of overweight and obesity in Chinese patients with first-episode drug-na?ve major depressive disorder[J]. JOURNAL OF AFFECTIVE DISORDERS,2021,286:351-359.
APA Si, Tong.,Yang, Kun.,Lang, XiaoE.,Dong, Xinglu.,Wang, Ningqun.,...&Qu, Miao.(2021).Prevalence and risk factors of overweight and obesity in Chinese patients with first-episode drug-na?ve major depressive disorder.JOURNAL OF AFFECTIVE DISORDERS,286,351-359.
MLA Si, Tong,et al."Prevalence and risk factors of overweight and obesity in Chinese patients with first-episode drug-na?ve major depressive disorder".JOURNAL OF AFFECTIVE DISORDERS 286(2021):351-359.
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